Gruetter

Question 1

Verapamil and diltiazem

Answer 1

Ca channel blockers - nondihydropyridines

Question 2

Minoxidil

Answer 2

K channel activators

Question 3

Nitroprusside, nitroglycerin, isosorbide dinitrate,NO, hyralazine

Answer 3

Guanylate cyclase activators

Question 4

Fenoldopam

Answer 4

Dopamine D1 receptor agonists

Question 5

Sildenafil, tadalafil

Answer 5

PDE inhibitor

Question 6

Lisinopril, Enlapril

Answer 6

ACEi

Question 7

Losartan, valsartan

Answer 7

AT2 receptor inhibitor

Question 8

Aliskrein

Answer 8

Renin inhibitor

Question 9

Arterial dilation decreases

Answer 9

AFterload, TPR

Question 10

Venous dilation decreases

Answer 10

CO and venous return

Question 11

Dihydropyridines (amilodipine) mainly causes vasodilation of _________ by decreasing influx of Ca via __________ Ca channels

Answer 11

Arteries

L-type

Question 12

In heart, L type Ca channels mainly inhibited by

Answer 12

Verapamil

Question 13

Verapamil inhibits phase ____________ of AP in muscle, to decrease Ca entry and decrease contractility

Answer 13

2 (plateau)

Question 14

Verapamil inhibits phase ________ of AP in SA and AV nodes. Decrease firing of SA node to decrease HR. Decrease conduction of AV to cause AV block.

Answer 14

0 (depolarization)

Question 15

Dihydropyridines (Amlodipine) mainly cause

Answer 15

Vasodilation

Question 16

Verapamil (nondihydropyridines) mostly affects

Answer 16

Heart

Question 17

All Ca channel blockers have __________ metabolism

Answer 17

Hepatic

Question 18

_____ can be used for chronic stable and variant angina, hypertension

Answer 18

All ca channel blockers

Question 19

____ can be used for supraventricular tachyarrhythmias and to terminate paroxysmal supraventricular tachycardia

Answer 19

Verapamil

Question 20

Increased risk of mortality and MI with _____________

Answer 20

Short acting dihydropyridine a

Question 21

Amlodipine

Answer 21

Ca channel blocker - dihydropyridine

Question 22

Adversely cause hypotension, edema, and headaches

Answer 22

Dihydropyridines ca channel blockers

Question 23

Adversely causes edema

Answer 23

Diltiazem

Question 24

Adversely causes hypotension, CHF, AV block, headaches, and constipation

Answer 24

Verapamil

Question 25

Avoid giving _____ if pt already has CHF or AV block

Answer 25

Verapamil

Question 26

Avoid ______ if pt already has hypotension or severe hepatic disease

Answer 26

All ca channel blockers

Question 27

Can interact with CYP3A4 drugs, concurrent beta blockers, and digoxin

Answer 27

Ca channel blockers

Question 28

Increased efflux of K will ______ the cell causing ___________ TPR

Answer 28

Hyperpolarize

Decreased