Antiarrhythimics 2

Question 1

Treats refractory life threatening ventricular tachycardia and sustained ventricular tachycardia

Answer 1

Amiodarone

Question 2

Highly lipophilic

Very long t1/2 (months)

Answer 2

Amiodarone

Question 3

Can cause pulmonary fibrosis, hyper/hypothyroidism, hepatotoxicity, AV block, bradycardia
Proarrhythmic

Answer 3

Amiodarone

Question 4

Class 3 and Class 1 actions
Prevents a flutter and a fib
t1/2 = 24 hrs

Answer 4

Droned alone

Question 5

Increased mortality in CHF

Answer 5

Dronedarone

Question 6

Causes liver injury/failure so monitor liver fn for 6 months

Answer 6

Dronedarone

Question 7

Prolong ADP/ERP
Terminate a flutter and a fib
Proarrhythmic, so can cause torsades de pointes

Answer 7

Ibutilide/Dofetilide

Question 8

Class 3 and non-selective beta blocker
Used in life threatening ventricular arrhythmias
Prevents recurrence of symptomatic a flutter and a fib
Prolongs QT causing torsades de pointes

Answer 8

Sotolol

Question 9

Decrease firing rate of SA node > Decreased HR
Decreased conduction velocity AV node
Increased APD and ERP

Answer 9

Verapamil (Ca channel blocker - class 4)

Question 10

Decreases contractility in atrial and ventricular muscle

Answer 10

Verapamil

Question 11

Causes vasodilation and decreased CO to decrease BP

Answer 11

Verapamil

Question 12

Verapamil inhibits phase _____ in SA and AV nodes

Answer 12

0

Question 13

Verapamil inhibits phase _____ in skeletal muscle

Answer 13

2

Question 14

Used for supraventricular arrhythmias, PSVT with AV nodal re-entry, and a flutter/Afib

Answer 14

Verapamil

Question 15

Adversely causes hypotension, CHF, AV block, and constipation

Answer 15

Verapamil

Question 16

Avoid with other beta blockers, digoxin, antiarrhythmics, and has hepatic metabolism interactions with cimetidine

Answer 16

Verapamil

Question 17

Decrease AV conduction
Short acting and rapid uptake 
Bonus 
Acute termination of PSVT 
Avoid asthma and COPD

Answer 17

Adenosine

Question 18

Controls ventricle rate in Afib and a flutter

Answer 18

Digoxin

Question 19

Use valsalva and carotid sinus massage to terminate

Answer 19

PVST

Question 20

Used to treat bradycardia by increasing AV and SA nodes

Answer 20

Atropine and isoproterenol

Question 21

Increases QRS and QT intervals

Answer 21

Procainamide

Question 22

No effect on PR, QT, or QRS

Answer 22

Lidocaine

Question 23

Dramatically increases QRS

Answer 23

Flecainide

Question 24

Increase PR interval (slowing AV node)

Answer 24

Propanolol

Question 25

Dramatically increases QT interval

Answer 25

Amiodarone

Question 26

Increase PR interval

Answer 26

Verapamil

Question 27

Highly efficacious.

DOC acute suppression of ventricular arrhythmias

Answer 27

Amiodarone