Vagina & Vulva Pathology Flashcards
Infection of the Vagina; usually due to Candida, Gardnerella or Trichomonas
Vaginitis
Common infectious causes of Vaginitis
Candida
Gardnerella
Trichomonas
The vast majority of PRIMARY tumors of the Vagina and Vulva are…
Squamous Cell Carcinoma (95%)
Most common malignant tumor of the Vagina in INFANTS and CHILDREN; consists of papillae, small nodules or confluent polypoid masses resembling grapes
Embryonal Rhabomyosarcoma
Clear Cell Adenocarcinoma is related to in utero _______ exposure
DES (Diethylstibestrol) (med to prevent spontaneous abortion in 1940s)
Type of Epithelium for the Vulva
KERATINIZED stratified squamous epithelium
Examples of Dermatitis of the Vulva
Eczema
Lichen Planus
Psoriasis
Acantholytic
Pruritic, painful, pale, flat white plaques; histology shows epidermal blunting with underlying zone of collagenized stroma and lymphocytic infiltrate
Lichen Sclerosus
Example of LOW grade squamous intraepithelial lesion of the Vulva; papillary, cauliflower-like lesions; usually due to HPV 6 and 11; histology shows papillary fronds with fibrovascular cores and hypergranulosis
Condyloma Acuminatum
Warty and Basaloid SCC of Vulva are almost always caused by…
HPV 16
Histologic findings for Condylomas
Papillary fronds Fibrovascular cores Epidermal hyperplasia Hypergranulosis (arrow) Koilocytes (curved line)
Histologic finding for Squamous Cell Carcinoma
Keratin pearls
Very rare malignancy originating in vulvar apocrine-gland-bearing skin cells or as a manifestation of adjacent primary anal, rectal or bladder adenocarcinoma; eczematous, pruritic lesion; histology shows enlarged glandular cells with abundant eosinophilic cytoplasm and atypical nuclei
Vulvar Paget Disease
Histology for Vulvar Paget Disease
Enlarged glandular cells
Abundant clear/eosinophilic cytoplasm
Atypical nuclei
*considered an adenocarcinoma in situ
