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Reproductive-Week 3/4 > Ovarian Pathology > Flashcards

Ovarian Pathology Flashcards

1
Q

Malignant neoplasm of EPITHELIAL cells; examples are adeno- and squamous

A

Carcinoma

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2
Q

Malignant neoplasm of MESODERMAL cells

A

Sarcoma

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3
Q

Cell appearance based on the resemblance of the tumor cell of the tissue of origin

A

Grade

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4
Q

Extent of the disease in the body

A

Stage

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5
Q

General types/origins of ovarian tumors

A

Surface/Epithelial
Sex cord/Stromal
Germ cell

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6
Q

The Corpus Luteum, a normal part of menstruation, has a __________ coloration

A

Yellow

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7
Q

Fibrous scar that forms after the Corpus Luteum degenerates (no implantation of a egg); lasts a few months

A

Corpus Albicans

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8
Q

Histologic findings for Serous Carcinoma

A

Papillary architecture
Nuclear “hob nailing”
Psammoma bodies

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9
Q

Risk factors for EPITHELIAL Ovarian Carcinoma

A 
Age
Nulliparity
Early Menarche
Late Menopause
BRCA1/2 mutation
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10
Q

Protective factors for EPITHELIAL Ovarian Carcinoma

A 
Breast feeding
OCPs
Tubal Ligation
Preganncy
Late Menarche
Early Menopause
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11
Q

Subtypes of Epithelial Ovarian Carcinoma (4 total)

A 
Serous (surface epithelium)
Endometroid
Mucinous
Brenner (transitional cell, urothelium, bladder)
Clear cell
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12
Q

Type of EPITHELIAL Ovarian Carcinoma; SOLID nodules with CYSTIC areas with thin serous fluid; can see Nuclear Hobnailing and Psammoma bodies

A

Cystadenocarcinoma

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13
Q

Gross appearance of Cystadenocarcinoma

A

Solid and cystic mass

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14
Q

Type of EPITHELIAL Ovarian Carcinoma; malignant columnar epithelial cells forming multiple smooth glands

A

Endometroid Adenocarcinoma

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15
Q

Histologic findings for Ovarian Endometroid Adenocarcinoma

A

Columnar cells forming numerous glands (but no mucin) (resemble endometrium, just invaginated)

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16
Q

Type of EPITHELIAL Ovarian Carcinoma; multiple malignant cells with CLEAR cytoplasm

A

Clear Cell Carcinoma

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17
Q

Type of EPITHELIAL Ovarian Carcinoma; malignant cells arranged in glandular architecture and filled with tons of MUCIN; appear purple-gray with bubbly cytoplasm

A

Mucinous Adenocarcinoma

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18
Q

Histologic findings for Ovarian Mucinous Adenocarcinoma

A

Malignant columnar cells FILLED with mucin

Purple-gray with bubbly cytoplasm

19
Q

Type of EPITHELIAL Ovarian Carcinoma; SOLID nests of Transitional-like cells (urothelial or bladder-like) encased in fibrous stroma; cells have grooved COFFEE BEAN nuclei

A

Brenner Tumor

20
Q

Histologic findings for Ovarian Brenner tumors

A

Solid bundles of transitional cells
Fibrous capsule
Grooved COFFEE BEAN nuclei

21
Q

Pathogenesis of EPITHELIAL Ovarian Carcinoma

A

Fallopian tube cells or retrograde menstruation dislodge and implant onto Ovarian surface

22
Q

BENIGN Epithelial tumor; Cystic mass with smooth, THIN external surface; simple flat (single layer) of epithelial lining; further divided into serous or mucinous subtypes

A

Cystadenoma

23
Q

Histologic findings for Cystadenoma

A 
Thin external surface
Either ciliated (serous) or mucinous
24
Q

Common BENIGN Sex Cord Stromal tumor; can RARELY cause Meig’s Syndrome (ascites and pleural effusion); composed of fibrous tissue surrounding the smooth muscle spindle cells

A

Ovarian Fibroma

25
Syndrome RARELY seen with Ovarian Fibromas; ascites and pleural effusion due to the filtration of interstitial liquid through ovarian tumor capsule
Meig's Syndrome
26
Sex-Cord Stromal tumors are derived from which cells
Granulosa and Theca Sertoli and Leydig Fibroblasts
27
MALIGNANT Sex Cord Stromal tumor of Theca cells; enlarged polyhedral cells with abundant cytoplasm and lipid droplets (steroid-secreting cells)
Thecomas
28
MOST common MALIGNANT Sex Cord Stromal tumor of Granulosa cells; present with excess ESTROGEN and INHIBIN; solid and lobulated; histology shows Call-Exner bodies (circular clusters) with grooved COFFEE BEAN nuclei
Granulosoma
29
Histologic findings for Granulosomas
Call-Exner Bodies (circular clusters) | Grooved COFFEE BEAN nuclei
30
Similarity between Brenner tumors (transitional epithelium) and Granulosoma tumors (malignant sex cord)
Grooved COFFEE BEAN nuclei
31
Ovarian Germ Cell tumor composed from the embryologic layers (endoderm, mesoderm, ectoderm); can be benign (adults) or malignant (children)
Teratoma
32
VAST majority of Teratomas in Adults; BENIGN; can see tissue from each embryologic layer (hair, teeth, skin, etc.)
Mature Cystic Teratoma ("Dermoid Cyst")
33
MOST common MALIGNANT Germ Cell tumor; composed of Primordial Germ cells; cells have glycogen-filled cytoplasm ("friend egg" cells) good prognosis with surgery and radiation
Dysgerminoma
34
Histologic findings for Dysgerminoma
Large polyhedral cells Large nucleoli Clear, glycogen-filled cytoplasm ("fried egg" cells)
35
Examples of Ovarian Germ Cell Tumors (5 total)
``` Teratomas (embryologic layers) Yolk Sac Tumors* Dysgerminoma* Choriocarcinoma* Embryonal Carcinoma* ``` *malignant
36
MALIGNANT Germ Cell Tumor; elevated serum AFP; mimic the primitive yolk sac; solid mass of hemorrhage and necrosis grossly; histologic findings are Schiller-Duval bodies ("glomeruloid like bodies")
Yolk Sac Tumor
37
Histologic finding for Yolk Sac Tumor
Schiller-Duval bodies ("glomeruloid like bodies")
38
METASTATIC Ovarian tumor; usually from GI tract tumors (stomach, colon, etc.); signet ring cell morphology; can be associated with intraperitoneal accumulation of mucin
Krunkenberg Tumor
39
The Serum marker CA125 is indicative of what Ovarian tumor?
Serous/Endometroid
40
The Serum marker CEA is indicative of what Ovarian tumor?
Mucinous
41
The Serum marker AFP is indicative of what Ovarian tumor?
Yolk Sac Tumor
42
The Serum marker hCG is indicative of what Ovarian tumor?
Choriocarcinoma
43
The Serum marker Inhibin is indicative of what Ovarian tumor?
Granulosa Cell Tumor
44
The Serum marker LDH is indicative of what Ovarian tumor?
Dysgerminoma

Reproductive-Week 3/4 (13 decks)

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