Vaccines Review

Question 1

Describe immunology?

Answer 1

B cells uptake antigen and present with MHC class 2…also produce IgM

T cells can be activated by dendritic cells that produce MHC 1 (if intracellular) or 2 molecules

T cell releases IFN (Th1), IL4 (Th2) and IL17 (Th17)…Il2 can feedback and activate T cells

When B cell binds to T cell, T cell produces IL4 and IFN which allows class switching and memory to occur

Question 2

Types of vaccines

Answer 2

Subunit (more targeted)

Killed (allows a lot to be delivered but not asimmunogenic)

Live-attenuated - immunogenic and mucsoal (produces IgA)

Adjuvant induces inflammation needed for subunit or killed

Question 3

B cells in primary vs. secondary

Answer 3

More antigen specific after

IgM>IgG before…IgG and IgA after

Low to high affinity and low to high somatic hypermutation

Question 4

Antibody levels and affinties after vaccination

Answer 4

Level of IgG will increase along with affinity

Won’t change for IgM

Question 5

Notable vaccine timeline

Answer 5

HepB is first
INfleuzna sarts at 6 mos
MMR, chicken pox, hepA - 1 year