Antifungal Podcast

Question 1

Summary of antifungal mech

Answer 1

Most inhibit ergosterol which is part of the membrane

Question 2

Azoles

Answer 2

Inhibit ergosterol synthesis

Keto - imidazole

Itraconazole, fluconaole and voriconazole are tri

Question 3

Azole mech, side effect, reistance

Answer 3

Lanosterol demethylase inhibitors

HUman and fungal are similar so both inhibited

Resistance emerged due to mutations

Question 4

Uses of azoles

Answer 4

Keto is older but itraconzole is used much more now

Will increase concentrations of P450 substrates

Question 5

Amphotericin B

Answer 5

Polyene

Punctures cell membranes

Binds to ergosterol

Broad spectrum with little resistance

rxns like fever and chills but can be treated with NSAIDs…dose-limting toxicity is renal

Question 6

Caspofungin

Answer 6

Inhibits 1,3-B-D-glucan synthase so can’t make cell wall

Lipopeptide that causes cell lysis

Active against candida and aspergillus…histo more variable…not active against crypto

Approved for use in aspergillosis and esophageal candidosis where amphotericin or fluconazole have failed

Question 7

Amantidine

Answer 7

Blocks uncoating of the RNA virus

Question 8

Oseltamivir

Answer 8

Blocks neuraminidases that degerate part of membrane that allows virus to be released

Needs to be used prior to full blown infection