Hib and PCV

Question 1

Hib

Answer 1

Was number one causde of bact meningitis under age of 5

Otitis in children and bronchitis in adults

Question 2

Spleen

Answer 2

Important part for Hib is the marginal zone where PS capsules are targeted…this does NOT occur in the lymph nodes so asplenia puts you at higher risk

Question 3

AB functions

Answer 3

Nuetralize toxins
Opsonize
Bind complement

Question 4

TI-2 antigens

Answer 4

Can signal B cells to produce IgM antibodies

Can also bind to dendritic cells…they release BAFF which induces class switching and B cells can then produce IgG

Question 5

Hib vaccine 1 and 2

Answer 5

First, tried to make it to the capsule but it was just an IgM response

Made a vaccine that targets the T cells by hooking it up to the tetanus toxin protein…loaded into MHC class 2 and presented to T cells

Question 6

S pneumo

Answer 6

Children less than 1 at highest risk for penumo meningitis

Question 7

S pneumo vaccine

Answer 7

Must be multivalent because there are many types with many different capsules

If you encounter one strain, it will not help you if you encounter a second strain