Uworld review 7 Flashcards
Who is given the PCV23 given alone, as opposed to in combination with the PCV13?
Less than 65, with other chronic medical conditions that increase the risk of invasive pneumococcal disease
What is the first line treatment myasthenia gravis? Second line?
- Acetylcholinesterase inhibitor–pyridostigmine
2. Immunosuppressive therapy
What is the first line treatment for acute aortic dissection? Why?
Labetalol, since it decreases BP and HR. If HR is left unchecked, then the dissection may propagate.
What is the most significant risk factor for TB?
Emigration from an endemic area.
How sensitive/specific is anti transglutaminase for celiac? What is the main caveat to this?
Pretty sensitive, but if IgA deficiency is present, then will not show up
What is collagenous colitis, and what will bx show?
Idiopathic increase collagen deposition, causing a malabsorption with mucosal subepithelial collagen deposition.
Does lactose intolerance cause malabsorption of other stuff?
No
Recent h/l dysentery + hepatic abscess on CT = ?
Entamoeba histolytica
What is the treatment for a hepatic cyst caused by entamoeba?
Metronidazole
How can you differentiate between a hepatic cyst caused by echinococcus vs entamoeba histolytica?
Echinococcus does not have fever, and is usually asymptomatic. Also requires exposure to dogs. None of these with ent.
How sensitive is stool microscopy for entamoeba histolytica infection that has formed an amebic abscess?
Not very
Why is drainage of a hepatic cyst caused by entamoeba histolytica not recommended?
Metronidazole alone will usually resolve it.
What are the s/sx of CMV colitis?
- Intermittent dysentery
- Abdominal pain
- Frequent, small volume diarrhea
At what CD4 count do CMV infections occur?
Below 50
What is the diagnostic test for CMV colitis? What will this show?
- Colonoscopy with bx
- eosinophilic intranuclear and basophilic intracytoplasmic inclusions
What is usually in the h/o a pt with an infection of entamoeba histolytica?
Recent travel abroad to an endemic country
Who should get the PSV-13 + 23 vaccines? (5)
- over 65
- CSF leaks, cochlear implants
- Sickle cell or asplenia
- Immunocompromised
- CKD
Who should get the PSV23 alone? (4)
- Chronic heart, lung, or liver disease
- DM
- Smokers
- Alcoholics
Under what CD4 count does MAC cause illness?
50
What are the s/sx of digoxin toxicity?
- n/v/d
- Scotoma / halos around lights
- confusion and weakness
What causes the osteopenia/porosis with ankylosing spondylitis?
osteoclast activity in the setting of chronic inflammation
What are the alarm symptoms of a pt presenting with GERD?
- B symptoms
- Men over age 50 with symptoms for 5+ years
- anemia
- Obvious stuff
When are colloids indicated?
Hypovolemia s/p paracentesis
What is the effect of dopamine on the kidneys?
Increased renal perfusion from D1 receptor stimulation
What is brachytherapy, and what is its role in brain tumors?
- Implanting radioactive/ablative material.
- In combination with surgery
When is surgery for brain cancer a particularly good option? (4)
- Limited mets/masses
- Accessible area
- younger than 65
- Stable extracranial disease
True or false: erythema marginatum is pathognomonic for lyme disease and, if present, preclude the need for serology
True
Most pts that become ill from vibrio vulnificus have what underlying pathology?
Liver disease
What is the cause of bernard soulier syndrome, and what are the labs results like?
- AR loss of glycoprotein Ib, which is a receptor for wVF.
- Mild thrombocytopenia, “Giant” platelets, and bleeding
What is the prophylaxis for malaria in chloroquine resistant areas (drug, and duration of treatment)?
Mefloquine 2 weeks before travel and 4 weeks after
What occupations or exposures, besides obvious ones, are associated with Pb poisoning? (3)
- distilling alcohol with Pb parts
- Battery manufacturing
- Plumbing
How do thiazides work to decrease Ca stone formation?
Increased water loss stimulates Na reabsorption, along with Ca. Thiazides do not inhibit Ca reabsorption like Loops do
What is the effect of aldosterone antagonists on urine Ca?
Increases urine Ca
What are the US characteristics of Echinococcus cysts?
Large, smooth cyst with daughter cysts inside
What is the treatment for small and large hepatic cysts d/t echinococcus?
Small = albendazole Large = drainage with prophylactic antihistamine
Clonus is suspicious for a lesion where?
Pyramidal tracts
What are pendular reflexes, and what do they suggest?
Slow, repeated (over 4 times) reflexes that are pendular in motion (not quick like clonus), and suggest cerebellar dysfunction
What are the classic s/sx of a morton’s neuroma?
Burning in the distal forefoot between the third and fourth metatarsals. Produces a clicking sensation and pain reproduction with squeeze over this area.
What is the treatment for a Morton’s neuroma?
Bar or padded shoe to reduce pressure over the metatarsals
What is the composition of most kidney stones?
Ca oxalate
What are Ca PO3 renal stones seen in?
Primary hyperPTH or RTA
What is the most common nephrotic syndrome seen in pts with Hodgkin’s lymphoma? What about other malignancies?
HL = Minimal change disease
Others (usually solid CAs) = membranous glomerulonephropathy
What almost always accompanies crescentic glomerulonephropathies?
AKI
What are the associated diseases with focal segmental glomerulosclerosis?
HIV
Heroin use
Obesity
Hep B is associated with which nephrotic syndrome?
Membranoproliferative
What causes a continuous murmur with coarctation of the aorta?
if collateral vessels form
Where is the murmur of coarctation of the aorta usually best heard?
Left infraclavicular area anteriorly, and left interscapular area posteriorly.
What might a CXR show with Ebstein’s abnormality?
Prominent right atrial contours
Brain mass in an HIV pt + ENV + serology =
Primary CNS lymphoma
What are the characteristics of a primary CNS lymphoma on head MRI?
Solitary, irregular, weakly ring enhancing mass in the periventricular area
What will head MRI reveal with toxoplasmosis?
Several ring-enhancing, spherical lesions in the basal ganglia.
Are the lesions with progressive multifocal leukoencephalopathy ring enhancing?
No
What is the treatment for euvolemic hypernatremia?
Free water supplementation
What is the treatment for hypovolemic hypernatremia? (2)
Symptomatic = NS until euvolemic, then D5 Asymptomatic = D5
How fast should hypernatremia be corrected?
0.5 mEq/dL/hr without exceeding 12 mEq/dL/day
If a pt develops Li-induced DI, what is the long term treatment if they cannot stop Li?
Salt restriction and selected diuretics (e.g. amiloride)
What is the MOA of amiloride?
ENaC inhibitor
When is hemodialysis indicated for the treatment of Li toxicity?
Serum Li levels over 4, OR over 2.5 + s/sx of significant toxicity
What is the typical presentation of a stress fracture?
-Abrupt increase in activity without rest, causing sharp, localized pain over a bony surface (most commonly the 2nd, 3rd, or 4th, metatarsals) that worsens with palpation over the area.
What is the treatment for a stress fracture?
Rest
What is the typical presentation of a morton’s neuroma?
Pain between the 3rd and 4th metatarsals on the plantar surface, and with a clicking sensation (Mulder sign) that occurs when simultaneously palpating this place and squeezing the metatarsal joints. Numbness/tingling into toes
https://www.youtube.com/watch?v=SCXzm4tLDTs
What is the usual pain with metatarsalgia?
Pain on the plantar surface of the foot between the 2nd and 3rd metatarsals. “Stepping on a rock”. No numbness/tingling
What causes the lower extremity edema with CCBs?
Preferential dilation of the precapillary vessels, which leads to increased capillary hydrostatic pressure and fluid extravasation into the interstitium.
What medication can be added to reduce the swelling associated with CCBs? How does this work?
ACEIs/ARBs
These cause post capillary venodilation, and can normalize hydrostatic pressure
What is malignant HTN?
HTN that causes papilledema or retinal hemorrhages
What is the treatment for exertional heat stroke?
Immersion in ice water
Osteolytic lesions + infections + anemia in a old person = ?
Multiple myeloma
What is the “ugly duckling” sign of melanoma?
If skin lesion is substantially different from other skin lesions
What is the Breslow depth?
Depth of melanoma from the stratum granulosum
What is the general treatment of actinic keratoses?
Local cryotherapy of topical 5FU
What is the preventative treatment for Acyclovir nephrotoxicity?
Aggressive IFVs
What are the screening recommendations for annual low dose CT?
55-80 year old with a 30+ pack year, wh0 are currently smoking or quit within the last 15 years
What is the recommendations for Pap smears?
- q3 years for 21-65 OR
- q5 years age 30-65 if combined with HPV testing
What is the usual presentation of mixed (type II) cryoglobulinemia? (4)
- Palpable purpura
- Renal disease
- Arthralgias
- Peripheral neuropathies
Mixed (type II) cryoglobulinemia is usually associated with which infection and autoimmune disease(s)?
HCV
SLE
HIV
Which antibodies are found with mixed (type II) cryoglobulinemia 2/2 HCV?
-anti-HCV IgG, and IgM anti-IgG abs (RF)
What happens to complement levels with mixed (type II)cryoglobulinemia? Type I?
I = normal II = Low