USMLE 2 Review Flashcards
What gallbladder disease is associated with ulcerative colitis?
Sclerosing cholangitis
What are the s/sx of a partial bowel obstruction? What is the appropriate treatment?
- Bilious emesis, but still able to pass flatus
- NPO, IVFs, and NG suction. O/w supportive
What are the s/sx of a complete bowel obstruction? What is the appropriate treatment?
- Bilious emesis, inability to pass flatus.
- Emergent laparotomy
What is the most common cause of death of patients with mitral stenosis 2/2 rheumatic fever?
CHF
What are the 6 P’s of compartment syndrome?
Pain Pulselessness Paresthesias Passive stretch pain Pallor Paralysis
What is the diagnostic test and treatment of choice for cholangitis?
ERCP
Air in the gallbladder wall = ?
Emphysematous cholecystitis (caused by gas producing bacteria)
Patient who are allergic to PABA cannot receive which local anesthetic class?
esters
What is the order of loss of nerve conduction sensations with local anesthetics? (5)
Pain Temp Touch Proprioception Skeletal muscle tone
What parts of the body should not receive local anesthetics with vasoconstrictors? (4)
Nose
Digits
Penis
Ear
What, technically, is an abrasion?
Superficial loss of epithelial elements, with portions of the dermis remaining intact
What are the three major phases of wound healing?
-
What are the different types of chronic wounds (4)?
- Pressure ulcers
- venous Stasis
- Arterial insufficiency
- Diabetic neuropathic ulcers
What is the treatment for pressure ulcers?
Movement
Saline moistened gauze
What is the treatment of venous stasis ulcers?
Compression
What causes the skin pigmentation associated with venous stasis ulcers?
Deposition of hemosiderin
What causes arterial insufficiency ulcers?
Plaque buildup lowers arterial blood delivery`
What is the treatment for arterial insufficiency ulcers?
Re Cannulate the artery or
What is the treatment for flash pulmonary edema 2/2 a-fib?
Cardioversion
What is Legg-Calve-Perthes disease?
Legg-Calvé-Perthes disease is idiopathic avascular necrosis of the femoral head that occurs most commonly in boys 4-10 years old. The parent typically reports that the child limps and complains of occasional hip or knee pain, as in this case. Early x-ray studies will show an increase in the density of the femoral head compared with the asymptomatic side.
What is the size of a carcinoid tumor at the appendix that is an indication for a right hemicolectomy?
More than 2 cm
What are the s/sx of a complete bowel obstruction?
Crampy, intermittent abdominal pain, increased BSm obstipation
What are the s/sx of paralytic ileus?
No BS
No focal TTP
Air throughout colon and small intestines
What are the IQ levels of mild, moderate, severe, and profound MR?
Mild = 50-70 Moderate = 35-49 Severe = 20-34 Profound = less than 20
Who is more likely to develop HTN from OCPs? (4)
- h/o pregnancy related HTN
- obese women
- over 35 years old
- Long time taking OCPs
What are the CXR findings suggestive of miliary TB?
Reticulonodular infiltrates spread evenly throughout both lung fields
Over how many centimeters are pulmonary nodules suspicious for cancer? What growth rate?
more than 3 cm
If doubles faster than every 2 years
What are the classic s/sx of an epidural abscess?
Fever, back pain, and midline spinal TTP
What is the imaging modality of choice for a suspected epidural abscess?
MRI
What are the classic histological findings for sarcoidosis?
Schaumann bodies and asteroid bodies
What is the classic pathogen that causes meningitis with elevated opening pressure in AIDS pts?
Cryptococcus neoformans
What labs are needed to to start a pt on an anti-HTN med? (3)
BMP
UA
Lipids
What is the role of citrate in the treatment of uric acid renal stones?
Turns to bicarb in the liver, and causes alkalinization of the urine
What type of hypersensitivity rxn is psoriasis?
Type IV
What are the classic PE findings of psoriasis?
Silvery plaques over extensor surfaces that bleed when scraped. Npt painful or pruritic.
What translocation produces follicular lymphoma?
t(14;18)
Which lymphoma does not need to be treated until symptomatic?
Follicular lymphoma
What needs to be checked frequently in patients with controlled pseudotumor cerebri?
Eyes–perimetry field testing
What is the therapy for pseudotumor cerebri (idiopathic intracranial HTN)? (2)
Lose weight
Acetazolamide
What is the first line drug in the treatment of thyroid storm?
Beta blockers
What is the treatment regimen for hyperthyroidism in pregnancy?
PTU for first trimester, then methimazole for second
What type of vaccine is the varicella vaccine?
Live attenuated
What is factitious thyrotoxicosis?
Administration of thyroid hormone in an attempt to lose weight
What malignancy is notorious for causing DI?
Langerhans cell histiocytosis
What is the hematological effect of desmopressin?
Increases vWF
Which abx can be used to treat SIADH? MOA (abx effect)?
Demeclocycline
Binds reversibly to 30x ribosomal subunit
What is the medical prophylaxis for small-medium esophageal varices? MOA?
Non-selective Beta blockers
Block adrenergic dilator tone in mesenteric arterioles
What is the protocol regarding vaccinations in a pt s/p bone marrow transplant?
vaccinate 3-6 months post op, avoid live attenuated for 24 months.
How does calcium restriction lead to an increase in renal stone formation?
Less Ca in diet mean more oxalate is absorbed from intestines, since no Ca to bind it. Oxalate then precipitates into kidneys, and pulls Ca with it, causing stones.
What are the three classic GI problem associated with Henoch-schonlein purpura?
Intussusception
Pancreatitis
Cholecystitis
What is the eye condition that patients with HLA-b27 are at increased risk of developing?
Anterior uveitis
What are the sizes of thyroid nodules that require bx if the TSH is normal?
If the nodule is solid and over 1 cm, FNA is indicated
If the nodule is mixed cystic and solid, 1.5 cm is needed.
What are the indications to begin statin therapy? (4)
DM
Atherosclerotic disease
LDL-C of 190 or higher
10 ASCVD risk of 7.5% or greater
How long does it take HIT to develop?
4-10 days if this is first exposure
What happens with HIT?
Thrombocytopenia, and a hypercoagulable state 2/2 platelet activation
What is the treatment for HIT?
Stop heparin, and switch to direct thrombin inhibitor, like argatroban or lepirudin
What is the MOA of carbidopa in the treatment of PD?
Increases L-dopa entry into the brain, by preventing its peripheral conversion to dopamine
What are the extrarenal symptoms of ADPKD?
Intracranial berry aneurysms
Mitral valve prolapse
What are the kidneys like with ADPKD? ARPKD?
Big with ADPKD
Small with ARPKD
What is the major extrarenal manifestation of ARPKD?
Liver cysts
What renal disease is associated with Hep B? What is the classic bx appearance of this?
Membranous nephropathy
Spike and dome
If a pt has a first degree relative diagnosed with colon cancer before age 50, when should they receive a colonoscopy?
10 years prior to their parent’s diagnosis
Which opioid can cause serotonin syndrome?
Meperidine
What is the MOA of phenelzine?
MAOI
What is the enzymatic deficiency of Gaucher’s disease?
glucocerebrosidase
Are bence jones proteins detected on a normal UA?
No
What are the classic CXR features of silicosis?
Calcifications of the hilar lymph nodes
What is POEMS syndrome?
Polyneuropathy Organomegaly Endocrinopathy Monoclonal protein Skin changes
What are the s/sx of POEMS syndrome, besides the POEMS symptoms?
Sclerotic bone lesions
Anemia
hyperuricemia
What is the diagnostic test for POEMS syndrome? What does this show?
Urine and serum electrophoresis
Shows a monoclonal M spike
Is the rash in pityriasis rosea pruritic?
Yes
What is the prognosis for pityriasis rosea?
Self limiting within a few months
What are the two major sulfonylureas?
Glipizide
Glyburide
What are the electroscopic findings of carcinoid tumors?
Dense core granules
Pleural plaques on CXR = ?
Asbestosis
What are the auscultatory findings of asbestosis?
Fine end inspiratory crackles
How can NSAIDs worsen dilated cardiomyopathy?
increase afterload and affect cardiac output by inhibiting prostaglandin synthesis (eliminated their effects on vasodilation) and by counteracting the benefits of ACEIs
What is the pathophysiology of the restrictive lung disease caused by coal pneumoconiosis?
Macrophages eat up the coal, and fibrosis in response
What are the cardiac manifestations of silicosis?
cor pulmonale
RVH
What is the Na, K , and acid/base status of a pt with addison’s disease?
Hyponatremic, hyperkalemic acidosis
aldosterone causes H and K secretion