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Uworld Outline - Renal > Uworld - Renal IV > Flashcards

Uworld - Renal IV Flashcards

1
Q

Ab against alpha3 chain of collagen type IV

A

goodpasture

anti GBM Abs

can lead to RPGN

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2
Q

crescent formation and fibrin deposits

A

RPGN

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3
Q

hemoptysis, linear IgG and C3, RBC casts

A

goodpasture

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4
Q

nasal ulcer and hemoptysis

A

wegener
cANCA

granulomatosis with polyangiitis

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5
Q

ANA positive, malar rash, pleural effusion

A

SLE

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6
Q

sensitive for SLE

A

ANA

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7
Q

specific for SLE

A

anti-dsDNA and anti-smith Abs

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8
Q

dysphagia and sclerodactylyl

A

CREST

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9
Q

anticentromere Abs

A

CREST

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10
Q

CREST syndrome

A 
calcinosis
raynauds
esophageal dysmotility
sclerodactylyl
telangiectasia
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11
Q

estimate of RPF

A

PAH clearance

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12
Q

FF =

A

GFR/RPF

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13
Q

RBF =

A

renal artery P - renal vein P / renal vasc resistance

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14
Q

NSAID nephropathy path

A

chronic interstitial nephritis
papillary necrosis

concentrate in renal medulla

  • higher in papilla than cortex
  • decreased PG synthesis - constriction medullary vasa recta - ischemia
  • uncouple ox phos - direct cell damage
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15
Q

acute rejection

A

infiltrate mononuclear cells

host T cells sensitiation against graft MHC antigens

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16
Q

graft vs. host disease

A

bone marrow transplant

graft T cell vs. host MHC

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17
Q

adverse of loops

A

hearing impairment

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18
Q

hearing impairment with drugs

A

loops
aminoglycosides
salicylates
cisplatin

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19
Q

adverse spironolactone

A

gynecomastia
impotence
decreased libido

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20
Q

triamterene

A

K sparing - ENaC blocker

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21
Q

adverse mannitol

A

high dose - pulmonary edema

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22
Q

primase

A

RNA primer - for DNA synthesis

DNA dependent RNA polymerase

23
Q

DNA ligase

A

single strand break repair

24
Q

DNA polymerase III

A

synthesis of daugher DNA

25
DNA polymerase I
replace RNA primer with DNA 5 > 3 exonuclease activity
26
helicase
unwind DNA at rep fork
27
diffusion equation
directly - concentration difference, SA, solubility inversely - membrane thickness, MW
28
ostedystrophy
pt with chronic renal failure ``` decreased calcitriol synthesis (1,25) -decreased Ca reabsorb, increased P retained -P binds Ca - exacerbate hypoCa -secondary hyperPTH -high bone turnover > osteitis fibrosa cystica ```
29
furosemide
loop diuretic inhibit Na/K/2Cl symport - ascending loop also - stimulate PG release - vasodilator > increased RBF > increased GFR
30
NSAID
decreased PG synthesis decrease loop diuretic effect
31
decreased loop effect
with NSAIDS - less PG - less vasodilation
32
endothelin
vasoconstrictor
33
ANG II
vasoconstrictor | aldosterone releaser
34
natriuretic peptides
ANP and BNP vasodilation, natriuresis, diuresis
35
bradykinin
vasodilation | pain
36
foamy urine
proteinuria decreased plasma osmotic P - get pitting edema
37
nephrotic in children
minimal change disease
38
aldosterone heart effect
causes remodeling and cardiac fibrosis stop this - with spironolactone -reduced mortality and morbidity
39
lithium and kidney
antagonist of vasopressin (ADH) in collecting duct nephrogenic DI
40
kidney embryo
pronephros - regress metanephros - wolffian duct - men mesonephros - true kidney
41
true kidney embryo
mesonephros form uteric bud - into mesoderm - induce metanephric mesoderm metanephric mesoderm = blastema -form glomeruli, bowman space, prox tubule, loop henle, DCT kidney migrate cephalad during development
42
CAI in eye
decrease aqueous humor production tx of angle closure glaucoma
43
exogenous vasopressin admin
V2 receptor - increase perm to water and urea in collecting duct - in central diabetes insipidus
44
Ca handling nephron
reabsorbed prox tube
45
GFR and FF with efferent vasoconstrictor
low level - increased GFR high level - decreased GFR - flow mediated rise in oncotic P in glomeruli caps FF - always increases
46
PGN hypersens
type III - IC deposition IgG and C3 - subepi humps granular
47
type IV hypersens cells
macros - CD8 T cells granuloma formation
48
cystinuria
auto rec defective transport of COLA -cysteine, ornithine, lysine, arginine increase stone formation
49
hexagonal stones
cystine
50
yellow/red-brown diamond or rhombus stones
uric acid
51
rectangular prism/coffin lid stones
magnesium ammonium P
52
octahedron stone
calcium oxalate square with X in center
53
elongated, wedge shaped rosette stones
calcium P
54
majority of kidney stones
70-80% calcium oxalate and P

Uworld Outline - Renal (8 decks)

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