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Uworld Outline - Renal > Uworld - Renal I > Flashcards

Uworld - Renal I Flashcards

1
Q

follows strep infection - age 6-10yo

facial and periorbital edema

A

PSGN

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2
Q

PSGN urinalysis

A

RBC casts

nephritic syndrome

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3
Q

deposits of PSGN

A

subepithelial humps of ICs

IgG, IgM, C3 granular

lumpy bumpy appearance

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4
Q

glomeruli of PSGN

A

enlarged/hypercellular

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5
Q

fibrin deposition

A

crescentic GN

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6
Q

blood vessel, smooth m, fat tumor of kidney

A

renal angiolympoa

benign

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7
Q

association renal angiolypoma

A

tuberous sclerosis - B/L

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8
Q

tuberous sclerosis

A

aut dom

  • cortical tubers
  • subependymal hamartomas in brain

seizure and mental retardation

cardiac rhabdomyoma

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9
Q

ash-leaf patche

A

leaf shaped patch of skin lacking pigment

-in tuberous sclerosis

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10
Q

NF1

A 
auto dom
neurofibromas
 optic gliomas
lisch nodules
cafe au lait spots
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11
Q

cafe au lait spots

A

NF1

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12
Q

lisch nodules

A

NF1

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13
Q

B/L acoustic neuromas

A

NF2

auto dom

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14
Q

VHL

A

auto dom
hemangioblastoma of cerebellum, retina, brain stem

cysts in pancreas, liver, kidney

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15
Q

dysregulated HIF-1

A

with von hippel lindau

VHL is tumor suppressor that down regulates HIF-1

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16
Q

risk of B/L renal cell carcinoma

A

VHL

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17
Q

leptomeningeal cap venous malformation of face

A

in sturge weber syndrome

facial - port wine stain

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18
Q

osler rendu weber syndrome

A

multi telengiectasia of skin and mucosa

recurrent epistaxis and bleeding

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19
Q

shagreen patch

A

leathery thick skin

-tuberous sclerosis

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20
Q

TSC1 and TSC2

A

tuberous sclerosis

1 - hamartin
2 - tuberin

mutation - proteins that inhibit mTOR - so more activity

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21
Q

UTI sex active women

A

staph saprophyticus

22
Q

MC cause UTI

A

E. coli

23
Q

tx of UTI

A

3 day course FQ or TMP/SMX

24
Q

recurrent UTI in boys

A

investigate for urinary tract obstruction

25
Q

common organism for urethritis

A

n. gonorrhoeae
c. trachomatis

pain burning when urinating

26
Q

glycolysis locadtion

A

in cytosol

27
Q

ox phos location

A

in mitochondria

28
Q

lactate DH

A

low O2 - pyruvate to lactic acid

-to regenerate NAD+

29
Q

pyruvate DH

A

high O2 - pyruvate to acetyl CoA

30
Q

acyclovir adverse

A

nephrotoxic

high concentration - crystalized

prevention - IV hydration

31
Q

hydration with acyclovir

A

to prevent renal damage from crystalization

32
Q

prednisone pre-treatment

A

to prevent radiocontrast allergic rxn

33
Q

allopurinol pre-treatment

A

lymphoma and leukemia - to prevent tumor lysis associated urate crystal nephropathy

34
Q

RAAS

A

activated - decreased Na, fluid volume, or arterial BP

renin released

renin - angiotensinogen > ANG I
ACE - ANG I > ANG II - and degrade bradykinin

35
Q

ANG II

A

vasoconstriction

and stimulate aldosterone release

36
Q

AT1 receptor

A

stimulated by ANG II

negative feedback - JG cell AT1 receptor activation
-results in decreased renin release

37
Q

ARB MOA

A

block AT-1 receptor
1 - vascular smooth m relaxation
2 - decreased aldosterone release

38
Q

breakdown of bradykinin

A

ACE

39
Q

clearance rate

A

= [urine] x urine flow rate / [plasma]

40
Q

Na/glucose carrier

A

in prox tubule

saturated at Tm

complete reabsorption - low concentrations

41
Q

inulin

A

estimate GFR

neither reabsorbed nore secreted

amount filtered = amount excreted

42
Q

creatinine

A

estimate GFR

43
Q

PAH

A

para-amino hippuric acid

estimate renal plasma flow

completely secreted

44
Q

urea

A

50% filtered is reabsorbed

45
Q

filtration fraction

A

FF = GFR/RPF

FF = GFR / (1 - hematoctrit) x RBF

46
Q

renal plasma flow

A

RPF = (1-hematocrit) x RBF

47
Q

elevated ASO titer and decreased C3 levels

A

PSGN

48
Q

starry sky appearance

A

PSGN

granular deposits of IgG, IgM, C3
-mesangium and BM

49
Q

IgE deposits

A

lupus nephritis

50
Q

C1q deposits

A

MPGN type 1

-subendothelial

Uworld Outline - Renal (8 decks)

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