Uworld more shit Flashcards

1
Q

beta blockers and diabetes

A

block the sympathetic response to low blood sugar;

nonselective beta blockers– use with caution (hypoglycemia)

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2
Q

equation for sensitivity

A

number of true positives/ total patients with the disease

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3
Q

how huntingtin suppresses other genes

A

histone de-acetylation

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4
Q

CMV shape and susceptibility

A

enveloped double-stranded DNA

intranuclear and intracytoplasmic inclusions- owl’s eye

esp. in patients with lung transplants

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5
Q

what is the significance of HLA-B*57:01 in AIDS patients?

A

avoid abacavir due to hypersensitivity reaction

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6
Q

what happens to RAAS in response to beta blockers

A

the whole system decreases, as they block the signal to renin

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7
Q

paraneoplastic cerebellar degeneration

A

destruction of purkinje fibers that goes with cancers

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8
Q

trapezius muscle injury

A

drooping of shoulder

impaired abduction above horizontal

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9
Q

what do high concentrations of fructose 2,6 bisphosphate do?

A

inhibit gluconeogenesis

–> decreased conversion of alanine and other stuff to glucose

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10
Q

umbilical hernia cause

A

incomplete closure of hte umbilical ring

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11
Q

a fistula between the aortic root and the right ventricle will lead to what kind of flow?

A

from aortic root to right ventricle, continuously

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12
Q

how acute pancreatitis causes trouble

A

premature activation of trypsinogen–> autodigestion

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13
Q

hep b mechanism or liver injury

A

cd8+ T lymphocyte response to viral antigens on the cell surface resulting in hepatocyte damage

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14
Q

timing of anti-psychotic side effects

A

akathisia- restlessness, days to weeks after initiation

dystonia- muscle contraction of mouth, tongue, eye muscles, within days of rx

tardive dyskinesia- involuntary movement disorder years after exposure

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15
Q

part of the brain responsible for pupillary reflex

A

Edinger Westphal nuclei in the midbrain

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16
Q

anaphylaxis with blood transfusion of O neg. What’s the likely dx?

A

selective igA deficiency can cause this.

17
Q

Wolf Parkinson White

A

short PR interval
widening of QRS interval
delta wave

can be associated with AV reentrant tachycardia and other arrhythmias

18
Q

what extra thing should pts on inhaled glucocorticoids do?

A

oral rinsing to prevent candidiasis

19
Q

how does alcohol serve as an antiseptic?

A

disruption of membranes, denaturation of proteins

20
Q

gardnerella microscopy

A

clue cells: epithelial cells covered with gram-variable rods

21
Q

sydenham chorea with acute rheumatic fever

A

molecular mimicry–> cross-reactivity

22
Q

B12 deficiency. What test establishes dx?

A

methylmalonic acid

23
Q

tricyclic antidepressant side effects

A

tremor, insomnia
hypotension
confusion, constipation, urinary retention
sedation

24
Q

how is HPV involved in carcinogenesis?

A

inhibition of cell cycle regulatory proteins

25
someone presents with mono but the horse antibody test is negative. What's likely?
CMV
26
MCD vs PSGN
not usually blood cell casts in MCD
27
symptoms of vitamin E defish
neuromuscular disease | hemolytic anemia
28
MS bladder issue
spastic bladder due to upper motor neuron lesion --> hypertonic bladder
29
rx for wide QRS inerval/ ventricular arrhythmia due to TCA overdose
sodium bicarb
30
main side effect of carbidopa/levodopa combination
anxiety and agitation
31
side effect of dihydropyridine CCBs
peripheral edema
32
opsoclonus-myoclonus syndrome in young kids goes with
neuroblastoma
33
pituitary hormones that must be replaced immediately
TSH, cortisol, and ADH