uWorld 19 Flashcards
what is train-of-four (TOF) stimulation
used during anesthesia to assess the degree of paralysis induced by NMJ-blocking agents
a peripheral nerve is stimulated 4 times in quick succession and the muscular response is recorded
the height of each bar represents the strength of each twitch; higher bars indicate the activation of increasing numbers of individual muscle fibers (myocytes)
what is seen on TOF stimulation when a NON depolarizing NMJ blocker (vercuronium) is administered
competitive inhibition of postsynaptic acetylcholine receptors at the motor endplate prevents some of these fibers from activating, decreasing the strength of the twitch
PROGRESSIVE REDUCTION in each of the 4 responses (FADING PATTERN) as a result of less acetylcholine being released with each subsequent impulse (due to additional effect of presynaptic acetylcholine receptor blockade)
what is seen on TOF stimulation when a depolarizing NMJ blocker (vercuronium) is administered
initially function by preventing depolarization of the motor endplate and show EQUAL REDUCTION of all 4 twitches during TOF stimulation (PHASE I BLOCKADE)
the responses remain equal b/c presynaptic acetylcholine receptor stimulation helps to mobilize presynaptic acetylcholine vesicles for release
persistent exposure to succinylcholine results in eventual transition to PHASE II BLOCKADE as the acetylcholine receptors become desensitized and inactivated (functionally similar to nondeplolarizing blockade)
succinyl choline is commonly administered for what
RAPID-SEQUENCE INTUBATION due to its rapid onset (less than 1 minute)
twisting injury or blow t the lateral knee while the foot is planted (VALGUS STRESS INJURY) to the knee results in what
MEDIAL COLLATERAL LIGAMENT (MCL) injury
what is the valgus stress test
performed when the knee is extended by placing one hand along the lateral thigh and pressing inward while the other hand is placed not eh medial aspect of the ankle and pushed outward
laxity of the knee and/or medial joint line widening indicate MCL injury
how is meniscal injury diagnosed
joint line tenderness while the knee is flexed
medial meniscal injury can occur with twisting moment of the knee and often accompanies MCL injury
what does the act do and what tests are there for its injury
resits anterior movement and the medial rotation of the tibia
injury indicated by increased anterior movement of the tibia in relation to the femur
anterior draw test
Lachman test
excessive backward movement of the tibia in relation to the femur indicates what
posterior draw test
PCL injury
what is ATTRITION BIAS
the loss of subjects differ in their rest of developing the outcome compared to the raining subjects
is a form of SELECTION BIAS
what is misclassification bias
occurs when exposure or the outcome is not identified correctly
random (or nondiffernetial) misclassification affects all the groups the same
Ex: pediatric cuff used on adults in a study but the control and the treatment used the same cuff = random missclassificaiton
NADH methemoglobin reductase does what and a deficiency results in what
reduces ferric (fe3+) iron to ferrous (Fe2+) iron, regenerating hemoglobin from methemoglobin deficiency results in methemoglobinemia
goblin chain denaturation occurs in what disorder
G6PD deficiency
what cytokine causes cachexia
TUMOR NECROSIS FACTOR-ALPHA (aka cachectin) by suppressing appetite and increases basal metabolic rate
along with IL-1beta and IL-6 are main mediators of paraneopalsic cachexia
TNF-alpha is produced by what and mediates what
macrophages fever (along with IL-1), mediates many of symptoms of septic shock, causes hepatic release of ACUTE PHASE REACTANTS (c-reactive protein, fibrinogen, hepcidin)
what does IL-3 do
produced by activated CD4+ Th cells
stimulates growth and fifernetiaiton of myeloid cells
what is the main function of TGF-beta
inhibition of inflammatory response
decreases T-cell proliferation and cytokine prodcution
what is seen histologically in the kidneys from the damage that calcineurin inhibitors (cyclosporine, tacrolimus) do
early arteriolar hyalinization and TUBULAR VACUOLIZATION
what is seen in wischott aldrich
WATER
thrombocytopenia (petechia, purpura, hematemesis and epistaxis)
eczema
recurrent infections (combined B and T-lyphocyte disorder)
increased risk of PYOGENIC INFECTIONS b/c they can’t mount immune response to things with polysaccharide capsule (N. meningitis, H flu, step pneumo)
t-cell defect they get fucked by PCP and HSV
becomes apparent at 6 months
treated with HLA-matched bone marrow
what are the important clinical findings of Chediak higashi
ocular albinism
peripheral neuropathy
immunodeficiency related to dysfunction of phagolysosome formation
what is seen in Krebbe disease
galactocerebroside accumulation
progressive neurodegeneration, peripheral neuropathy, optic atrophy
what is seen in Fabry disease
globotriaosylceramide accumulation
causes angiokeratomas, peripheral neuropathy, and glomerulopathy that typically present in adulthood
what is seen in von Gierke disease
glucose-6-phosphatase deficiency hepatomegaly hypoglycemia seizures lactic acidosis
what is seen in pompe
lysosomal alpha-1,4-glucosidase deficiency
cardiomegaly
severe hypotonia
blood supply to the femoral head derives mainly from where
ascending cervical and retinaclular branches of the MEDIAL CIRCUMFLEX ARTERY (branch off deep femoral)
what arteries form the trochanteric anastomosis
branches of the lateral circumflex and superior and inferior gluteal arteries join with the medial circumflex artery
what vessel is important in children because it supplies the region of the femoral head proximal to the epiphyseal growth plate
artery of ligamentum heres (form the obturator artery)
minimal clinical significance in adults
abdominal and flank bruits are specific for what
renal artery stenosis
but found in minority of patients
what is a root cause analysis
quality improvement measure that aims to identify what, how and why an undesirable outcome occurred
first step is collecting data to obtain complete information about the event or events
RB tumor suppressor gene (anti-oncogene) is located where
Ch 13
a blood flow curve showing cyclical variation in flow during the cardiac cycle, with MAXIMUM FLOW occurring during DIASTOLE and minimal flow occurring during ventricular systole is unique for what tissue
LEFT VENTRICULAR MYOCARDIUM
majority of blood flows through the vascular beds when the myocardium is relaxed and not comprising the vessels
systolic reduction in flow is greatest in subendocardial myocardium (where wall pressure is the highest)- region is prone to ischemia and MI
the right ventricle blood flow appears how throughout the cardiac cycle
relatively constant
pressures in right ventricle are much lower than the left, and as a result the increase in systemic blood pressure during diastole is able to compensate for the rise in right ventricular wall pressure
what are markers of osteoclast activity and what is the most reliable of the three
tartrate-resistant acid phosphatase urinary hydroxyproline (also found in meat products) urinary DEOXYPYRIDINOLINE (most reliable)
what is a reflects osteoblastic activity
bone-specific alkaline phosphatase
what does pyridinoline do
covalently cross-links collagen fibers
these cross-links are the most commonly used method in assessing osteoclastic activity
whats the difference between urticaria and angioedema
urticaria is due to increased permeability of the micro vasculature leading to edema of the SUPERFICIAL DEMRIS
angioedema is involvement of the deep semis and subcutaneous tissue
what is dyskeratosis
abnormal, premature keratinization of individual keratinocytes
strongly eosinophilic and may have small, basophilic nuclear remnant
found in squamous cell carcinoma
what is acantholyisis
loss of cohesion b/w keratinocytes in the epidermis
seen in pemphigus family of disorders
what is acanthosis
diffuse increase in thickness of the status sinus (prickle cell layer) b/w the granular cell layer and the basal layer of the epidermis
psoriasis, seborrheic dermatitis, acanthosis nigricans
what is spongiosis
intercellular epidermal edema that histologically appears as an increase in the width of places b/w cells
often associated with spongiotic dermatitis, which encompasses a number of conditions (eczematous dermatitis)
URTICARIA a common transient HYPERSENSITIVITY disorder is characterized by intensely pruritic, raised, erythematous plaques (WHEALS) that arise suddenly and resolve over several hours, what causes this
IgE-meidated degranulation of mast cells
can also be due to non-IgE-mediated degranulation (opiates, radiocontrast agents, physical urticaria) or mast cell independent mechanisms (aspirin, hereditary andgioeurotic edema)