uWorld 17 Flashcards
what clears particles stuck in the terminal bronchioles of the lungs
CILIATED CELLS
mucociliary clearance is responsible for removing particles from most of the bronchial tree
ciliated cells reach up to the proximal portions of the respiratory bronchioles
when do macrophages clear stuff from the lungs
distal to the terminal bronchioles
when is the ACTH stimulation test used
adrenocortical insufficiency
give them METYROPONE (which blocks conversion of 11-doxycortisol to cortisol)
in primary insufficient addition of metyropone
what is caused by absent tyrosinase activity
albinism (AR)
defects in biosynthesis of melanin most commonly due to tyrosinase activity (converts DOPA to dopaquinone)
what is the earliest lesion of atherosclerosis and what is the predominant cell type in this structure
FATTY STREAK
made up of lipid-laden macrophages (foam cells) in the intimal that can eventually progress to atherosclerotic plaques
what is the sequence of atherosclerotic progression
ENOTHELIAL INJURY/DYSFUNCITON causing increased vascular permeability and enhanced leukocyte adhesion
accumulation of lipoproteins (LDL) within the vessel wall)
MONOCYTE ADHESION to the endothelium,followed by migration and transformation into lipid-laden MACROPHAGES (FOAM CELLS)
release of growth factors by the adherent platelets, activated macrophages, and endothelial cells
recruitment of T cells and SMOOTH MUSCLE CELL PROLIFERATION, which lead to extracellular metric production
what anti epileptic drugs can also be used as mood stabilizers for bipolar
VALPROATE
carbamazepine
lamotrigine
stimulation of what adrenergic receptor decreases insulin secretion and what increases it. what is the overall effect
alpha 2- decreases secretion
beta 2- increases secretion
alpha-2 effects predominate thus inhibition insulin secretion
M3 receptors work through what kind of G protein and have what effect on insulin secretion
Gq
increase insulin secretion
what is glucagon-like peptide 1
incretin hormone secreted by the intestinal L-sells in response to food and acts on receptor found on pancreatic beta cells to potentiate glucose-induced insulin release
blocking these receptors reduces insulin please
H2 receptor stimulation has what effect on insulin secretion
increases it
what is the normal pressure in the SVC and Right atrium
1-6 mmHg
what is the normal pressure of the right ventricle
systolic: 15-30 mmHg
diastolic: 1-6 mmHg (just below RA pressure)
what is the pulmonary artery pressure normally
systolic: 15-30 mmHg (no change from right ventricle)
diastolic: 6-12mmHg
what is the normal pulmonary capillary wedge pressure (what does it represent)
usually quell to PA diastolic pressure: 6-12mmHg
reflective of the venous pressure in the left heart (Left Atrial pressure and left ventricular diastolic pressure)
A1AT deficiency typically manifests with what kind of emphysema
EASLY-ONSET
lower lobe-predominant
panacinar
what accounts for the rubber-like properties of elastin
formation of DESMOSINE CROSS-LINKS b/w neighboring polypeptides by LYSYL OXIDASE prewires copper) oxidatively delaminating some of the lysine residues of tropoelastin
what do the disulfide bridges formed during collagen synthesis do
bring the chains of the C-terminal propertied regions of the 3 alpha chains into favorable alignment for triple helix assembly
in cryptorchidism what becomes atrophic and hyalanized, why
seminiferous tubules
result of temperature-induced damage
(Leydig cells not affected as much)
what is mono neuritis multiplex
peripheral neuropathy of multiple individual nerves
associated with a variety of diseases- Wegener and PAN
what is the MOA of risperidone
INHIBITS D1 and D2
inhibits serotonergic and alpha-adrenergic pathways
what characterizes polycystic ovary disease
INFERTILITY OLIGOMENORRHEA HYPERANDROGENISM most pts are OBESE insulin resistance is thought to play a role in pathogenies
what characterizes primary ovary syndrome
AMENORRHEA
HYPOESTROGENISM
elevated gonadotropin levels in women under 40
uterine fibroids have what effect on menses
menorrhagia
disruption of the arcuate fascicles leads to what
CONDUTION APHASIA
fluent speech, intact comprehension, impaired repetition
what is the hypothalmospinal tract
projects form hypothalamus to the ciliospinal center of the intermediolateral cell column (T1-T2)
providing sympathetic innervation to IPSILATERAL eye and face
HORNER SYNDROME
pt with depression, suicidal ideation, and impulsivity (substance abuse, unprotected sex) in the setting of feeling rejected are characteristic of what personality disorder
BORDERLINE
patients with borderline disorder frequently come to clinical attention due to what
suicidal behavior or threats during an interpersonal crisis
modd swings that occur in response to interpersonal stressors
what patients are at increased risk for severe disease with V vulnificus
chronic liver disease (like hepatitis)
in what situations is the infectious dose of V cholera less than normal
decreased acidity in the environment (increases in gastric pH)- antacid use or any condition causing achlorhydria
what nerve innervates the area of internal hemorrhoids (above dentate line)- covered in columnar epithelium
INFERIOR HYPOGASTRIC PLEXUS
only sensitive to stretch and not pain, temp or touch
has both sympathetics and parasympathetic