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REPRO II Exam 1 > Uterine Pathology II > Flashcards

Uterine Pathology II Flashcards

1
Q

type 1 endometrium epithelium adenocarcinoma

A

glandular - endometroid

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2
Q

type 2 endometrium epithelium adenocarcinoma

A

surface - non-endometroid

-papillary serous carcinoma
MMMT - carcinomcarcinoma

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3
Q

myometrium neoplasms

A

leiomyoma

leiomyosarcoma

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4
Q

endometroid adenocarcinoma

A

type 1

80% of endometrial cancer

peak age 45-55yo
with conditions of unopposed estrogen

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5
Q

mutations of endometroid adenocarcinoma

A

type 1

PTEN - mutation

KRAS - microsatellite instability

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6
Q

conditions of unopposed estrogen

A 
exogenous estrogen 10 years
endogenous - ovarian tumor
estrogen from peripheral conversion of androgen - PCOS, obesity, androgen tumor
infertility
diabetes
HTN
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7
Q

abnormal bleeding, prolonged periods of 6 month duration

A

endometroid adenocarcinoma - type 1

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8
Q

grade of endometroid adenocarcinoma

A

based on number of lumens

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9
Q

tamoxifen

A

risk fx for type 1 - endometroid adenocarcinoma of uterus

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10
Q

absence of PTEN stain

A

type 1 - endometroid adenocarcinoma

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11
Q

non-endometroid adenocarcinoma

A

type 2

  • all high grade and aggressive**
  • early lymph spread

papillary serous carcinoma

15% of endometrial carcinomas

post-menopausal disease**

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12
Q

cancer of endometrium post-menopause

A

type 2

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13
Q

mutation in p53

A

non-endometroid adenocarcinoma of endometrium - type 2

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14
Q

MMMT

A

malignant mixed mullerian tumor
carcinosarcoma

bulky polypoid mass

distinct epithelial and mesenchymal components**

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15
Q

papillary architecture

A

serous carcinoma - type 2 non-endometroid adenocarcinoma

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16
Q

positive p53

A

non-endometroid adenocarcinoma

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17
Q

precursor to type 1

A

hyperplasia / EIN

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18
Q

precursor to type 2

A

endometrial intraepithelial carcinoma

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19
Q

african america, thin, atrophy

A

type 2 endometrial cancer

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20
Q

grade and stage of endometrium cancer

A

grade - differentiation
1 - well
2 - moderate
3 - poor

stage - location
1 - corpus uteri
2 - corpus and cervix
3 - extends outside uterus 
4 - outside true pelvis or mucosa of bladder/rectum
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21
Q

all type II nonendometroid carcinomas

A

high grade

22
Q

carcinosarcoma

A

MMMT

adenocarcinoma and sarcoma together

bad - aggressive

23
Q

surgery for uterine carcinoma

A

unless grade 1 type 1 endometroid adenocarcinoma

and fertility preservation
or poor surgical candidate

24
Q

trial for hormone therapy

A

type 1 endometroid adenocarcinoma
fertility preservation
poor surgical candidate

do therapy instead of surgery**

25
Q

post-menopausal bleeding

A

common presentation of type 1 endometroid adenocarcinoma

26
Q

omenectomy

A

if non-endometroid adenocarcinoma (type 2) - serous

OR carcinosarcoma

27
Q

ifosfamide

A

adjuvant therapy - if carcinomsarcoma with rhabdomyosarcoma elements

28
Q

candidate for lynch syndrome screening

A 
age <50
bethesda guieline criteria
tumor with lymphocytes
lower uterine origin
concurrent ovarian cancer
29
Q

stroma cancer of uterus

A

B9 stromal nodule
endometrial stroma sarcoma
adenosarcoma

2 and 3 - bad - malignant

30
Q

large sessile polyp protruding through cervical os

A

adenosarcoma

31
Q

endometrial stromal nodule

A

benign - but need to differentiate from sarcoma

32
Q

spindle cell neoplasma

A

endometrial stromal sarcoma

5 year survival 50%

33
Q

CD10 IPX stain

A

endometrial stromal sarcoma

34
Q

sheets of blue cells

A

stromal cells

-endometrial stromal sarcoma

35
Q

MED12 mutation

A

unique to smooth m
-leiomyoma

and leiomyosarcoma

36
Q

leiomyoma

A

benign smooth muscle neoplasm

fibroid

37
Q

leiomyoma vs. leiomyosarcoma

A

both have MED 12 mutation

distinguish by number of mitotic figures**

38
Q

mets for leiomyosarcoma

A

blood vessels - hematogenous spread

39
Q

location of leiomyoma

A

determines the symptoms

  • bleeding - submucosa
  • pelvic fullness - large mass
  • urinary frequency - pressure against bladder
  • infertility and miscarriage may occur
40
Q

MED12 with numerous mitotic figures on histo

A

leiomyosarcoma

41
Q

dilation and curettage

A

dilation of cervix

scraping of uterine wall

42
Q

salpingitis

A

inflammation of fallopian tube

with PID

43
Q

acute bacterial salpingitis

A

suppurative - pus

60% gonnococcus
40% chlamydia
-differentiate with culture

44
Q

pyosalpinx and hydrosalpinx

A

tube scar shut - with salpingitis

45
Q

complications of saplingitis

A

adhesions
infertility
ectopic pregnancy

46
Q

paratubal cysts

A

arise in mullerian remnants

at fimbriated end of tube or in broad ligament

translucent, thin walled, unicameral

aka hydatid cysts of morgagni

47
Q

ectopic pregnancy

A

abnormal implantation
-with PID, adhesions, or endometriosis

tube ruptures 12 weeks - hemorrhage life threatening

section of tube - shows chorionic villi

48
Q

most common site of ectopic

A

ampulla of tube 70%

49
Q

endometrium hypersecretory with no chorionic vili

A

possible ectopic pregnancy

50
Q

high risk for ectopic

A 
previous ectopic
tubal surgery
tubal ligation
IUD use
PID
multiple sex partners
smoking
51
Q

methotrexate

A

tx option for ectopic - destroys fetal tissue

52
Q

fallopian adenocarcinoma

A

possible source of high grade serous carcinoma of ovary

REPRO II Exam 1 (14 decks)

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