Placental Pathology I Flashcards
placental delivery
third stage of delivery
looking at placenta during delivery
child surface
maternal surface
all placental vessels - are childs
trapped placenta
cannot deliver
dislodged from wall - but abnormal contraction of lower uterus stops expulsion
placental delivery steps
uterus contract - except what is connected to placenta
uterus relaxation - except connected to placenta - dislodge with shear force
global contraction - expels placenta
important to look at with cord
count vessels**
if 2 - structural and chromosomal abnormalities - 35% of time
progesterone
following ovulation increase
-prepares endometrium for implantation - secretory and blood vessel rich
placental implantation
week 1-2
produce HCG - prevents loss of CL
trophoectoderm
2 layers - of chorionic villi
-synctiotrophoblast
cytotrophoblast
spiral arteries
from endometrium - go up into placental tissue
smooth muscle cells invaded by cytotrophoblasts
- high pressure system to low resistance system
- allows pooling of blood
abnormalities - lead to preeclampsia
eclampsia pathology
placental factors to the mother
neutrophils on amniotic membrane
always abnormal
first trimester chorionic villi
have syncytiotrophoblast (outer) and cytotrophoblasts (inner)
50% of fertilizations
spontaneous abortion
metabolic transfer in chorionic villi
most syncytiotrophiblast
third trimester chorionic villi
stroma with dense network of dilated capillaries surrounding thinned syncytiotrophoblasts and cytotrophoblasts
pregnancy lost <20 weeks
spontaneous abortion
1st trimester abortion
chromosomal problem
50% of spontaneous abortions
2nd trimester abortion
mechanical problem
3rd trimester abortion
fetoplacental unit problem
risk factors for spontaneous abortion
increased age
history of prior
maternal smoking
ectopic pregnancy location
90% fallopian tubes
predispose to ectopic
PID - 35-50%
diagnosis of ectopic
beta-HCG
ultrasound
laparoscopy
most important predisposing condition for ectopic?
hx of PID
highest relative risk for ectopic?
smoking
dichorionic
fraternal twins
monochorionic
identical twins