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REPRO II Exam 1 > Hormone Contraception - Linger > Flashcards

Hormone Contraception - Linger Flashcards

1
Q

human menopause gonadotropin

A

menotropin

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2
Q

chorionogonadotrope alpha

A

RhCG

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3
Q

pulsatile gonadotrope

A

stimulatory

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4
Q

conjugated estrogen

A

premarin

natural

less potent

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5
Q

synthetic estrogens

A

estradiol valerate
ethinyl estradiol
mestranol

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6
Q

norethindrone

A

progestin

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7
Q

etonogestrel

A

active progestin - desogestrel

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8
Q

desogestrel

A

inactive prodrug - progestin

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9
Q

drospinenone

A

progestin

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10
Q

porgestimate

A

progestin

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11
Q

norgestrel

A

progestin

L and levo also - L isomer is active

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12
Q

mifepristone

A

progesterone receptor antagonist

induces leutolysis

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13
Q

anastrazole

A

aromatase inhibitors

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14
Q

exemestane

A

aromatase inhibitors

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15
Q

letrozole

A

aromatase inhibitors

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16
Q

clomiphene

A

selective estrogen receptor downregulator

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17
Q

fulvestrant

A

selective receptor receptor downregulator

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18
Q

tamoxifen

A

selective estrogen receptor modulator

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19
Q

ER receptor positive breast ca resistant to tamoxifen

A

fulvestrant

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20
Q

women with fibroids

A

give no estrogen

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21
Q

hormone contraception

A

estrogen/progestin combo

progestin only

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22
Q

estrogen receptor

A

alpha and beta isoforms

bind ligand and HSP disocciation
leads to dimerization of receptor

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23
Q

CI of estrogen

A

undiagnosed genital bleeding

heavy smoker

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24
Q

protective against endometrial cancer

A

estrogen/progestin combo

25
Q

OTC ovulation kit

A

measures LH levels

26
Q

hCG

A

from placenta

-acts on LH receptors

27
Q

estrogen in contraceptive

A

ethinyl estradiol

28
Q

injectable contraceptive

A

medroxyprogesterone acetate

29
Q

nuvaring

A

ethinyl estradiol
etonegestrol

rapid return to fertility*

30
Q

transdermal contraception

A

ethinyl estradiol

norelgestromin

31
Q

IUD

A

levonorgestrel - mirena

rapid return to fertility

32
Q

implantable contraceptive

A

etonogestrel

rapid return to fertility

33
Q

plan B

A

levonorgestrel

34
Q

ella

A

ulipristal acetate

prescription emergency contraception

35
Q

estrogen in HRT

A

premarin - natural conjugated estrogen

less potent

36
Q

breakthrough bleeding

A

progestin only contraceptives

37
Q

medroxyprogesterone acetate hormonal

A

androgenic

antiestrogenic

38
Q

desogestrel hormonal

39
Q

norethindrone hormonal

A

androgenic

40
Q

L-norgestrel hormonal

A

androgenic

41
Q

progesterone receptor

A

A and B isoforms

42
Q

progestin half life

43
Q

HRT with estrogen and progestin

A

increased breast ca

decreased endometrial ca

44
Q

progestin only contraceptive

A

don’t block as well - but have other mechanisms of action - thick mucus - endometrial alterations

45
Q

endometrial hyperplasia

A

prevented with progestin

46
Q

lowest failure rate

A

implantable

etonogestrel

47
Q

failure of oral contraceptive

48
Q

termination of pregnancy

A

mifepristone and misoprostol (PGE2)

49
Q

clomiphene

A

partial agonist at estrogen receptors

50
Q

prescription morning after

A

ullipristal acetate

51
Q

agonist at lipid and bone, antagonist on endometrium and breast

A

raloxifene

52
Q

tamoxifen MOA

A

competitive partial agonist inhibitor of estradiol at estrogen receptor

53
Q

hirsutism

A

norethindrone

levonorgestrel

54
Q

primary hypogonadism

A

estrogen therapy

after 1st bleeding - add progestin

55
Q

CI for estrogen only contraceptive

A

smoker >35yo

no HTN, CAD, diabetes

56
Q

SERM

A

tamoxifen and toremifene

adverse - hot flashes

57
Q

oral estrogen vs. transdermal

A

more effect on circulating proteins produced by liver

transdermal - decreased change serum lipids

58
Q

estrogen and lipids

A

increased HDL and TGs

decreased LDL and cholesterol

REPRO II Exam 1 (14 decks)

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