Uterine Cancer Flashcards

1
Q

what is most common cause of AUB-O ovulatroy dysfxn?

A

anovulatory cycles that lead to high estrogen from non ovulated follicle and eventual breakthrough bleeding

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2
Q

acute endometritis is from what?

A

usually bacteria

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3
Q

what cell is there in acute endometritis?

A

neutros

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4
Q

what are some causes of chronic endometritis?

A

PID, IUDs with actinomyces

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5
Q

what cell is there in chronic endometritis?

A

plasma cells

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6
Q

what is cause of endometrial hyperplasia?

A

unopposed estrogen

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7
Q

what is endometrial hyperplasia a precursor of?

A

endometrial carcinoma

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8
Q

what is clinical sign of endometrial hyperplasia?

A

abnormal uterine bleeding

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9
Q

what are the two types of endometrial hyperplasia? which is malignant?

A

hyperplasia without cytologic atypia/benign

cytologic atypical hyperplasia/premalignant

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10
Q

what is cytologic atypia in endometrial hyperplasia?

A

atypia of nucleus with enlargement and rounding, chromatin clumping, loss of nuclear polarity

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11
Q

how is endometrial hyperplasia without atypia treated>

A

with progesterone

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12
Q

what happens to gland:stroma ration in endometrial hyperplasia without atypia?

A

greater than1:1 but glands look normal

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13
Q

describe the process of moving from regular endometrium to endometrium carcinoma

A

start with anovulatory bleeding and see benign hyperplasia that changes to atypical hyperplasia and then endomterial carcinoma

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14
Q

name the four types of endometrial carcinoma?

A

serous
mucinous
endometroiod
clear cell

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15
Q

what is excluded in endometrial carcinoma?

A

stroma isnt present anymore

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16
Q

what is rx for endometrial carcinoma?

A

hysterectomy followed by radiation and progesterone therapy

17
Q

what is a big risk factor for endometrial carcinoma? why?

A

obesity…prob increase in estrogen levels from adipose tissue

18
Q

what are the two classes of endometrial carcinoma?

A

type 1 and 2

19
Q

what differentiates type 1 and 2 endometrial carcinoma?

A

type 1 responds to estrogen and type 2 is not estrogen related

20
Q

who gets type 1 endometrial carcinoma?

A

young and heavy

21
Q

who gets type 2 endometrial carcinoma?

A

old and thin

22
Q

which of type 1 or 2 is more favorable?

A

type 1

23
Q

what is another name for uterine serous adenocarcinoma?

A

papillary serous carcinoma

24
Q

what are two histo features of papillary serous carcinoma?

A

nuclear hobnailing and papillary structures

25
Q

type II endometrial carcinoma is what structure?

A

papillary serous carcinoma

26
Q

type 1 endometrial carcinoma is what architecture?

A

glandular architecture

27
Q

endometrial mucinous adenocarcinoma is what type of endometrial carcinoma?

A

type 1

28
Q

how does clear cell adenocarcinoma of uterus appear on histo?

A

clear cell sytoplasm with high grade pleomorphic nuclei

29
Q

what is a histo finding for leiomyomas?

A

cigar shaped nuclei in smooth muscle cells

30
Q

what is the tumor of the smooth muscle myometrium?

A

leiomyosarcoma

31
Q

do leiomyomas directly lead to leiomyosarcoma ?

A

no

32
Q

are leiomyosarcomas hormone dependent like leiomyomas?

A

NO

33
Q

how do leiomyomas appear grossly?

A

whitish and whorled

34
Q

how do leiomyosarcomas appear grossly?

A

red and soft

35
Q

what do leiomyosarcomas have on histo?

A

atypia with mitoses and necrosis