Uterine Cancer

Question 1

what is most common cause of AUB-O ovulatroy dysfxn?

Answer 1

anovulatory cycles that lead to high estrogen from non ovulated follicle and eventual breakthrough bleeding

Question 2

acute endometritis is from what?

Answer 2

usually bacteria

Question 3

what cell is there in acute endometritis?

Answer 3

neutros

Question 4

what are some causes of chronic endometritis?

Answer 4

PID, IUDs with actinomyces

Question 5

what cell is there in chronic endometritis?

Answer 5

plasma cells

Question 6

what is cause of endometrial hyperplasia?

Answer 6

unopposed estrogen

Question 7

what is endometrial hyperplasia a precursor of?

Answer 7

endometrial carcinoma

Question 8

what is clinical sign of endometrial hyperplasia?

Answer 8

abnormal uterine bleeding

Question 9

what are the two types of endometrial hyperplasia? which is malignant?

Answer 9

hyperplasia without cytologic atypia/benign

cytologic atypical hyperplasia/premalignant

Question 10

what is cytologic atypia in endometrial hyperplasia?

Answer 10

atypia of nucleus with enlargement and rounding, chromatin clumping, loss of nuclear polarity

Question 11

how is endometrial hyperplasia without atypia treated>

Answer 11

with progesterone

Question 12

what happens to gland:stroma ration in endometrial hyperplasia without atypia?

Answer 12

greater than1:1 but glands look normal

Question 13

describe the process of moving from regular endometrium to endometrium carcinoma

Answer 13

start with anovulatory bleeding and see benign hyperplasia that changes to atypical hyperplasia and then endomterial carcinoma

Question 14

name the four types of endometrial carcinoma?

Answer 14

serous
mucinous
endometroiod
clear cell

Question 15

what is excluded in endometrial carcinoma?

Answer 15

stroma isnt present anymore

Question 16

what is rx for endometrial carcinoma?

Answer 16

hysterectomy followed by radiation and progesterone therapy

Question 17

what is a big risk factor for endometrial carcinoma? why?

Answer 17

obesity…prob increase in estrogen levels from adipose tissue

Question 18

what are the two classes of endometrial carcinoma?

Answer 18

type 1 and 2

Question 19

what differentiates type 1 and 2 endometrial carcinoma?

Answer 19

type 1 responds to estrogen and type 2 is not estrogen related

Question 20

who gets type 1 endometrial carcinoma?

Answer 20

young and heavy

Question 21

who gets type 2 endometrial carcinoma?

Answer 21

old and thin

Question 22

which of type 1 or 2 is more favorable?

Answer 22

type 1

Question 23

what is another name for uterine serous adenocarcinoma?

Answer 23

papillary serous carcinoma

Question 24

what are two histo features of papillary serous carcinoma?

Answer 24

nuclear hobnailing and papillary structures

Question 25

type II endometrial carcinoma is what structure?

Answer 25

papillary serous carcinoma

Question 26

type 1 endometrial carcinoma is what architecture?

Answer 26

glandular architecture

Question 27

endometrial mucinous adenocarcinoma is what type of endometrial carcinoma?

Answer 27

type 1

Question 28

how does clear cell adenocarcinoma of uterus appear on histo?

Answer 28

clear cell sytoplasm with high grade pleomorphic nuclei

Question 29

what is a histo finding for leiomyomas?

Answer 29

cigar shaped nuclei in smooth muscle cells

Question 30

what is the tumor of the smooth muscle myometrium?

Answer 30

leiomyosarcoma

Question 31

do leiomyomas directly lead to leiomyosarcoma ?

Answer 31

no

Question 32

are leiomyosarcomas hormone dependent like leiomyomas?

Answer 32

NO

Question 33

how do leiomyomas appear grossly?

Answer 33

whitish and whorled

Question 34

how do leiomyosarcomas appear grossly?

Answer 34

red and soft

Question 35

what do leiomyosarcomas have on histo?

Answer 35

atypia with mitoses and necrosis