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Repro Week 3 > Ovarian Cancer > Flashcards

Ovarian Cancer Flashcards

1
Q

what are the three subtypes of ovarian cancer?

A

surface/epithelial
sex cord/stroml
germ cells

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2
Q

what are the two most common benign ovarian neoplasms?

A

serous and mucinous cystadenoma

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3
Q

what are serous and mucinous cystadenomas derived from?

A

epithelium

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4
Q

what is lining of a benign serous cystadenoma?

A

fallopian tube like ciliated serous epithelium

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5
Q

what is lining of a benign mucinous cystadenoma?

A

non stratified mucinous epithelium

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6
Q

what is the most common ovarian malignancy?

A

serous cystadenocarcinoma

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7
Q

what is the mass of a serous cystadenocarcinoma made of?

A

cystic and solid components

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8
Q

what is histo feature of ovarian serous carcinoma?

A

papillary architecture with high grade nuclei that are hob nailing

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9
Q

what is a specific finding for serous carcinoma of ovary?

A

psammoma bodies

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10
Q

grossly what will there be in serous carcinoma of ovary?

A

thin serous fluid around cystic areas

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11
Q

grossly what will you see in mucinous carcinoma of ovary?

A

solid nodules with thick mucinous fluid

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12
Q

what is endometrioid adenocarcinoma of ovary associated with?

A

endometriosis

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13
Q

what are histo features of ovarian endometrioid adenocarcinoma?

A

columnar epithelium cells making glands and pink eosinophilic cytoplasm

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14
Q

what is a brenner tumor made of?

A

transitional urothelial like cells

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15
Q

what does a brenner tumor look like on histo?

A

nests of urothelial cells encased in a dense fibrous stroma

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16
Q

what is thought to possibly lead to ovarian serous carcinoma?

A

displacement of fallopian tube cells

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17
Q

what are the two common malignant sex cord ovarian tumors?

A

granulosa and leydig/sertoli

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18
Q

what do granulosa tumors produce a lot of?

A

estrogen

19
Q

what do sertoli/leydig tumors produce a lot of?

A

testosterone

20
Q

what is the common benign sex cord stromal tumor?

A

fibroma

21
Q

what can an ovarian fibroma present with?

A

Meigs syndrome

22
Q

what is Meigs syndrome?

A

ovarian fibroma leads to ascites and pleural effusions

23
Q

what will an ovarian fibroma have in it?

A

collagen and spindle cells

24
Q

what is the famous histo finding of a granulosa cell tumor of the ovary?

A

Call Exner bodies

25
Q

what are call exner bodies?

A

coffee bean linear nuclie of cells

26
Q

aside from a granulosa tumor, what other ovarian malignancy can have linear nuclear grooves?

A

brenner tumor

27
Q

what is most common adult ovarain germ cell tumor?

A

teratoma

28
Q

name the five germ cell tumors an ovary can have

A 
teratoma
dysgerminoma
choriocarcinoma
embryonal carcinoma
yolk sac tumor
29
Q

what is the dysgerminoma in an ovary the same as in a male?

A

seminoma

30
Q

where is tissue from in a teratoma

A

from 2 or 3 germ layers

31
Q

what is the cell type seen in a dysgerminoma?

A

fried egg cells…large tumor cell with a clear cytoplasm

32
Q

what is elevated in a yolk sac tumor?

A

serum AFP

33
Q

what is appearance of a yolk sac tumor?

A

solid mass with hemorrhage and necrosis

34
Q

what is histo finding for a yolk sac tumor?

A

schiller duval bodies

35
Q

how do schiller duval bodies appear? what are they associated with?

A

they are associated with yolk sac tumors and look like glomeruloid like structures

36
Q

what is a krukenburg tumor?

A

metastasis to ovary from the stomach

37
Q

what cell is common in a krukenburg tumor?

A

signet ring cell

38
Q

what do metastatic ovarian cancers do more often than normal ovarian tumors?

A

they are bilateral

39
Q

what are four common metastatic origins for ovarian cancer?

A

stomach colon pancreas
breast
GYN cancer

40
Q

what are the two types of teratomas?

A

mature and immature

41
Q

what differentiates a mature from immature teratoma?

A

the tissue is mature in a mature one and immature in immature

42
Q

what is another name for a mature teratoma?

A

dermoid cyst

43
Q

what is a struma ovarii?

A

dermoid cyst mature teratoma that is made of thyroid tissue

Repro Week 3 (10 decks)

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