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Repro Week 3 > Male Pharmacology > Flashcards

Male Pharmacology Flashcards

1
Q

what does low T induce?

A

low sperm production

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2
Q

what does exogenous high T lead to?

A

low sperm production due to HPG inhibition

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3
Q

what is an ANS drug class that can lead to ED?

A

beta blockers…because they decrease the flow

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4
Q

what is the MoA of the PDE5 inhibitors in treating ED?

A

penile vascular smooth muscle relaxation

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5
Q

name some SEs of PDE5 inhibitors

A

syncope
hypotension
headache
priapism

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6
Q

what is a weird SE of PDE5 inhibitors

A

cyanopsia…vision is blue

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7
Q

what drug class canPDE5 inhibitors interact with that is not good?

A

nitrates

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8
Q

what is the PGE1 analog that is used for ED?

A

alprostadil

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9
Q

what is the MoA of alprostadil?

A

PGE1 analog that increases cAMP and in turn decreases Ca2+

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10
Q

how do you give alprostadil?

A

injection

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11
Q

what is the PDE5 inhibitor that is given as injection?

A

papaverine

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12
Q

what ANS drug can help with ED?

A

phentolamine

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13
Q

why does phentolamine help with ED?

A

alpha antagonist leads to vasodilation

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14
Q

how do you treat priapism?

A

inject with phenylephrine

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15
Q

what is MOA of phenylephrine?

A

a agonist to induce vasoconstriction

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16
Q

what ANS class is given for BPH?

A

a1 antagonists

17
Q

what is the a1 antagonist that is most ocmmonly used for BPH?

A

tamsulosin

18
Q

what do a1 receptors usually cause at prostate?

A

closing of urethra and urinary retention…so blocking helps open it up

19
Q

what is the molecule in charge of growth in BPH?

A

DHT

20
Q

what is a drug you can give to limit amount of DHT?

A

finasteride…5a reductase inhib

21
Q

what is MoA of finasterid?

A

5a reductase inhibitor that leads to less DHT

22
Q

what can finasterid also help with? sorta random

A

androgenic alopecia

23
Q

aside from tamsulosin and finasteride what is another med that may be effective for BPH?

A

tadalafil…PDE5

24
Q

what is goal of therapy in prostate cancer?

A

androgen deprivation

25
Q

what is a testosterone synthesis inhibitor?

A

ketoconazole

26
Q

what is a testosterone releasing inhibitor?

A

leuprolide

27
Q

what are testosterone receptor antagonists?

A

flutamide

spiranolactone

28
Q

what are the four drugs to consider for prostate cancer?

A

ketoconazole
leuprolide
spironolacton
flutamide

Repro Week 3 (10 decks)

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