Male Pharmacology Flashcards
(28 cards)
what does low T induce?
low sperm production
what does exogenous high T lead to?
low sperm production due to HPG inhibition
what is an ANS drug class that can lead to ED?
beta blockers…because they decrease the flow
what is the MoA of the PDE5 inhibitors in treating ED?
penile vascular smooth muscle relaxation
name some SEs of PDE5 inhibitors
syncope
hypotension
headache
priapism
what is a weird SE of PDE5 inhibitors
cyanopsia…vision is blue
what drug class canPDE5 inhibitors interact with that is not good?
nitrates
what is the PGE1 analog that is used for ED?
alprostadil
what is the MoA of alprostadil?
PGE1 analog that increases cAMP and in turn decreases Ca2+
how do you give alprostadil?
injection
what is the PDE5 inhibitor that is given as injection?
papaverine
what ANS drug can help with ED?
phentolamine
why does phentolamine help with ED?
alpha antagonist leads to vasodilation
how do you treat priapism?
inject with phenylephrine
what is MOA of phenylephrine?
a agonist to induce vasoconstriction
what ANS class is given for BPH?
a1 antagonists
what is the a1 antagonist that is most ocmmonly used for BPH?
tamsulosin
what do a1 receptors usually cause at prostate?
closing of urethra and urinary retention…so blocking helps open it up
what is the molecule in charge of growth in BPH?
DHT
what is a drug you can give to limit amount of DHT?
finasteride…5a reductase inhib
what is MoA of finasterid?
5a reductase inhibitor that leads to less DHT
what can finasterid also help with? sorta random
androgenic alopecia
aside from tamsulosin and finasteride what is another med that may be effective for BPH?
tadalafil…PDE5
what is goal of therapy in prostate cancer?
androgen deprivation
