Urinary tract/reproductive Flashcards
What is finesteride and how does it work?
it is 5alpha-reductase inhibitors - it reduces the size of prostate, by inhibiting conversion of testosterone to dihydroteststosterone
What are the common indications for finesteride?
benign prostate hyperplasia
What are important adverse effects of finesteride?
antiandrogen - impotence, low libido, gynaecomastia, breast cancer
What are warnings of finesteride?
pregnant women shouldn’t use! (prevents development of genitalia)
What are the interactions with finesteride?
N/A
What are some examples of alpha-blockers and how do they work?
doxazosin, tamsulosin, alfuzosin
they cause vasodilation which results in fall in BP, reduced resistance in bladder outflow
What are indications of alpha blockers?
first line treatment of prostatic enlargement
used to treat resistant hypertension
What are some adverse effects of alpha blockers?
hypotension, dizziness, syncope
What are warnings with alpha blockers?
postural hypotension
What are important interactions with alpha blockers?
Other drugs that cause vasodilation
What are some antimuscarinics used for genitourinary reasons, what are they used for and how do they work?
oxybutynin, tolterodine, solifenacin
used to treat overactive bladder
they cause bladder relaxation, and reduce bladder symptoms
What are some adverse effects of genitourinary antimuscarinics?
dry mouth, tacycardia, constipation, blurre vision
What are some cautions and interactions with genitourinary antimuscarinics?
don’t use in UTI
caution in elderly, dementia, angle-closure glaucoma, arrhythmias, urinary retention
don’t give with other antimuscarinic drugs
