Urinary System 2: Ureters, Bladder, & Urethra Flashcards

1
Q

PCT is the 1st

A

segment of the renal tubule

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2
Q

Where Does the PCT begin?

A

at the urinary pole of the glomerulus

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3
Q

Where does a majority of glomerular flitrate get resorbed?

A

PCT

70%

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4
Q

PCT is very very

A

convoluted

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5
Q

what are the name in order of the parts of the Loop of Henle?

A
  • Pars recrta (thick)
  • thin descending
  • thin ascending
  • thick ascending limb
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6
Q

The thin portion of the loop of Henle has

A

squamous epithieum

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7
Q

The thick parts of the Loop of henle has

A

cubodial epitheilum

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8
Q

What wraps around the loop of henle?

A

Vasa recta

is parallel to

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9
Q

Loope of henle serves to create

A

high osmotic pressure in the renal
medulla

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10
Q

The loop of Henle creates high osmotic pressure in the renal medulla via the

A

counter-current multiplier system

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11
Q

The loop of henle counter-current multiplier system hel to create

A

hypertonic urine

excretion of excess solute

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12
Q

The bulk of the loop of henle extends into the

A

medula

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13
Q

In juxtamedullar nephorns thin limbs are

A

long

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14
Q

in cortical neprhons thin limbs are

A

short

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15
Q

Pars recta has a

A

brush border

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16
Q

There is a _________ extracellular Na in the medulla

A

higher

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17
Q

Countercurrent multiplier funciton is to

A

to generate high osmotic pressure in ECF of renal medulla

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18
Q

How does the Countercurrent multiplier generate hgih osmotic pressue inthe ECF

A

via Na-K pump in thick acsending

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19
Q

The vasa recta arises form

A

efferent arterioles of
juxtamedullary
nephrons

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20
Q

Distal convoluted tubule continuation of

A

thick ascending
limb of Loop of Henle

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21
Q

Where is the DCT located

A

in the cortex

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22
Q

DCT has cuboidal epithelium but

A

lacks brush border

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23
Q

DCT is Responsible for

A
  • active resorption of Na & Cl
  • coupled with secretion of H & K ions
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24
Q

What are the two cell types of the DCT?

A
  • prinicpal cells
  • intercalated cells
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25
Q

prinicpal cells resorb

A

Na & water

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26
Q

prinicpal cells secrete

A

K

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27
Q

intercalated cells mediate secretion of

A

H + and HCO3 −

28
Q

intercalated cells mediate reabsorption

A

Cl − and K+

29
Q

What is important Regulators of Acid- Base Balance

A

intercalated cells

30
Q

intercalated cells are important

A

Regulators of Acid- Base Balance

31
Q

prinicpal cells and intercalated cells are controled by

A

aldosterone

adrenal mineralocorticoid

32
Q

JGA stands for

A

juxtaglomerular apparatus

33
Q

Juxtaglomerular apparatus is combined

A
  • baroreceptor (pressure)
  • chemoreceptor ([ion]
34
Q

Juxtaglomerular apparatus regulates

A

blood pressure

35
Q

Juxtaglomerular apparatus regualtes blood pressure via

A

renin-angiotensin-aldosterone system
(RAAS)

36
Q

parts of the renin-angiotensin-aldosterone system
(RAAS)

A
  1. macula densa
  2. juxtaglomerular cells
  3. extraglomerular mesangial cells
37
Q

Macula densa __________ sensitive to changes in ________in filtrate.

A

Chemoreceptor; Na

38
Q

Macula densa are found in

A

side of distal convoluted tubule

39
Q

Juxtaglomerular cell are found in

A

wall of afferent arteriol

40
Q

Juxtaglomerular cells Act as _________; detect changes in _______

A

baroreceptors; blood pressure

41
Q

Juxtaglomerular cells produce ______ in response to low BP

A

renin

decrease Blood volume

42
Q

Renin converts

A

angiotensinogen to angiotensin

43
Q

Extraglomerular mesangial cells are found

A

surrounding afferent and efferent arteriole

44
Q

Extraglomerular mesangial cells fucntion

A

unclear; provide structural support & phagocytosi

45
Q

Extraglomerular mesangial cells may assist in

A

tubular glomerular feedback

info from macula densa to intraglomerular mesangial cell

46
Q

What watch if the BP is low

A
  • Macula Densa
  • Juxtaglomerular
47
Q

intraglomerular mesangial cells

function

A

contraction/relaxation may change glomerular filtration rate

48
Q

Macula densa acts as sensor, regulating

A

juxtaglomerular
function by monitoring Na+ &
Cl- levels in the DCT

49
Q

Angiotensinogen is converted to

A

active
angiotensin 1

by renin

50
Q

Angiotensin causes

A

suprarenal glands to secrete
aldosterone

51
Q

What converts Angiotensin 1 to 2

A

ACE

Angiotensin Converting Enzyme

52
Q

ACE inhibitors helop to treat

A

hypertesnion (high blood pressure)

53
Q

DCT dumps into

A

collecting tubules

isotonic urine

54
Q

Collecting tubules dump into

A

collecting ducts

isotonic urine

55
Q

Collecting duct leave

A

cortex and enters medulla all the way down to the papilla

56
Q

Collecting Ducts play an important role in

A

final concentration of urine

interstitium & vasa recta

57
Q

ADH causes collecting ducts to

A

increase the number of aquaporins in their walls

58
Q

Epithelium responsive to

A

antidiuretic
hormone (ADH, Vasopressin)

59
Q

antidiuretic
hormone is released by

A

posterior pituitary

60
Q

ADH cause

A

water to be lost from ducts

hypertonic urine

61
Q

Without ADH

A

ducts remain
impermeable to water

iso-/hypotonic urine

62
Q

Mutations to AQP-2

A

do not respond to ADH

in diabetes

63
Q

After reaching the papilla what is the order that urine travels?

A

minor calyces
major calyces
renal pelvis
ureter

64
Q

Ureter lined by

A

transitional epithelium

65
Q

Urinary Bladder lined by

A

Urothelium (transistental)
ballon surface

Stratified