urinary antiseptics, polymyxins, glycopeptides Flashcards
glycopeptides
vancomycin and telavancin
glycopeptide coverage
gram postive (MRSA)
anaerobes (c.diff)
enterococci
VRE (telavancin only)
glycopeptide use
hospital acquired pneumonia, skin and soft tissue infection, meningitis, c.diff (2nd line)
How to treat c.diff
oral vancomycin; 2nd line
What treats VRE
telavancin
ADR glycopeptide
Red-Man syndrome
glycopeptide have additive toxicity with? What is the result?
AMG leading to ototoxicity and nephrotoxicity
glycopeptide has a contraindication with
corn allergy and VANCO allergy
ADR telavancin
Red man syndrome, metallic taste, nephrotoxicity, QT prolongation
is VANCO time or concentration dependent
time; cidal
What is IV VANCO used for?
gram postive bacteria
What levels do we measure in VANCO
trough
What is the “go to” agent if a patient needs G+ coverage but allergic to PCN?
VANCO
telavancin is time or concentration dependent?
concentration; cidal
dosing of telavancin
every 24-48 hours, no monitoring of levels
Polymyxins
Polymyxins B and Polymyxins E
Polymyxins coverage
gram negative only
resistant strains of acintebacter, pseudomonas, and klebsiella
Polymyxins use
organisms resistant to other antibiotics
ADR Polymyxins
Neurotoxicity, nephrotoxicity
Different uses for Polymyxins B and Polymyxins E
Polymyxins B is seen in neosporin
Polymyxins Eis seen in systemic use for highly resistant bacteria
urinary antiseptics
nitrofurantoin and fosfomycin
urinary antiseptics use
UTIs and cystitis
urinary antiseptics coverage
gram positive and gram negative
ADR urinary antiseptics
pulmonary reactions and peripheral neuropathy
Nitrofurantoin contraindications
patients with creatine clearance under 60 and patients with G6PD deficiency
What is the drug of choice for pregnant women with UTI
nitrofurantoin (don’t use at end of pregnancy)
Concern for nitrofurantoin
elderly concern due to renal and pulmonary ADR
