urinary antiseptics, polymyxins, glycopeptides

Question 1

glycopeptides

Answer 1

vancomycin and telavancin

Question 2

glycopeptide coverage

Answer 2

gram postive (MRSA)
anaerobes (c.diff)
enterococci
VRE (telavancin only)

Question 3

glycopeptide use

Answer 3

hospital acquired pneumonia, skin and soft tissue infection, meningitis, c.diff (2nd line)

Question 4

How to treat c.diff

Answer 4

oral vancomycin; 2nd line

Question 5

What treats VRE

Answer 5

telavancin

Question 6

ADR glycopeptide

Answer 6

Red-Man syndrome

Question 7

glycopeptide have additive toxicity with? What is the result?

Answer 7

AMG leading to ototoxicity and nephrotoxicity

Question 8

glycopeptide has a contraindication with

Answer 8

corn allergy and VANCO allergy

Question 9

ADR telavancin

Answer 9

Red man syndrome, metallic taste, nephrotoxicity, QT prolongation

Question 10

is VANCO time or concentration dependent

Answer 10

time; cidal

Question 11

What is IV VANCO used for?

Answer 11

gram postive bacteria

Question 12

What levels do we measure in VANCO

Answer 12

trough

Question 13

What is the “go to” agent if a patient needs G+ coverage but allergic to PCN?

Answer 13

VANCO

Question 14

telavancin is time or concentration dependent?

Answer 14

concentration; cidal

Question 15

dosing of telavancin

Answer 15

every 24-48 hours, no monitoring of levels

Question 16

Polymyxins

Answer 16

Polymyxins B and Polymyxins E

Question 17

Polymyxins coverage

Answer 17

gram negative only

resistant strains of acintebacter, pseudomonas, and klebsiella

Question 18

Polymyxins use

Answer 18

organisms resistant to other antibiotics

Question 19

ADR Polymyxins

Answer 19

Neurotoxicity, nephrotoxicity

Question 20

Different uses for Polymyxins B and Polymyxins E

Answer 20

Polymyxins B is seen in neosporin

Polymyxins Eis seen in systemic use for highly resistant bacteria

Question 21

urinary antiseptics

Answer 21

nitrofurantoin and fosfomycin

Question 22

urinary antiseptics use

Answer 22

UTIs and cystitis

Question 23

urinary antiseptics coverage

Answer 23

gram positive and gram negative

Question 24

ADR urinary antiseptics

Answer 24

pulmonary reactions and peripheral neuropathy

Question 25

Nitrofurantoin contraindications

Answer 25

patients with creatine clearance under 60 and patients with G6PD deficiency

Question 26

What is the drug of choice for pregnant women with UTI

Answer 26

nitrofurantoin (don’t use at end of pregnancy)

Question 27

Concern for nitrofurantoin

Answer 27

elderly concern due to renal and pulmonary ADR