macrolides Flashcards
1
Q
macrolide
A
azithromycin
clarithromycin
erythromycin
2
Q
macrolide coverage
A
gram positive (staph and strep)
respiratory gram negative (h. flu, catarrahalis, neisseria)
atypical (chlamydia, legionella, pneumonia)
3
Q
macrolide use
A
respiratory track infections, alternative to PCN allergy, mycobacterium
4
Q
ADR macrolide
A
QT prolongation, GI intolerance, anorexia, rash, elevated LFTs, jaundice
5
Q
DDI for macrolide
A
3A4 substrate and inhibitor (erythro> clari)
6
Q
Macrolide’s time-dependent or concentration dependent? Bacteriostatic or -cidal?
A
time-dependent and static