Anti-TB

Question 1

MOA of isoniazid

Answer 1

inhibit synthesis of mycolic acids

Question 2

What is the most active drug for TB

Answer 2

isoniazid

Question 3

ADR isoniazid

Answer 3

hepatitis, peripheral neuropathy, SLE

Question 4

What is peripheral neuropathy due to in isoniazid?

Answer 4

loss of pyridoxine (B6)

Question 5

DDI isoniazid

Answer 5

CYP 2C9 inhibitor

Question 6

MOA rifampin

Answer 6

inhibits RNA synthesis

Question 7

Rifampin coverage

Answer 7

gram positive and gram negative cocci

enteric bacteria, mycobacteria and chlamydia

Question 8

Rifampin use

Answer 8

GI disorders, meningitis (add on) and serous staphylococcal infections (osteomyelitis and endocarditis)

Question 9

ADR rifampin

Answer 9

orange colored urine, sweat, feces
cholestatic jaundice
thrombocytopenia
flu-like symptoms (prophylax before)

Question 10

What 2 drugs combined will cure TB 95-98% of time?

Answer 10

isoniazid-rifampin

Question 11

DDI of rifampin

Answer 11

strong inducer of CYP 450 and high protein plasma binding

Question 12

pyrazinamide MOA

Answer 12

disrupts mycobacterial cell membrane metabolism

Question 13

pyrazinamide use

Answer 13

MDR-TB

Question 14

If combined pyrazinamide combined with isoniazid and rifampin what will happen?

Answer 14

add it to first two months of treatment to decrease duration of therapy to 6 months

Question 15

ADR pyrazinamide

Answer 15

hepatotoxicity
hyperuricemia
mild arthralgia/myalgia

Question 16

how does hyperuricemia develop in pyrazinamide

Answer 16

pyrazinamide inhibits uric acid filtering–> gout

Question 17

ethambutol MOA

Answer 17

inhibit RNA synthesis

Question 18

ethambutol use

Answer 18

MDR-TB

Question 19

ADR ethambutol

Answer 19

optic neuritis
confusion and disorientation
hallucinations
hypercuricemia

Question 20

Ethambutol can’t be used in what age group and why?

Answer 20

you’re than 13 because of the optic neuritis (color blind)

Question 21

2 drugs for MRD-TB

Answer 21

pyrazinamide and ethambutol