Urinary 1 Flashcards

1
Q

How many Kidneys are found in the human body?

Where are they located?

How much does each kidney weigh?

A

2 kidneys

Retroperitoneal organs

Lateral to vertebrae (T11 to L3)

Left higher than right

150g each

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2
Q

What structures immediately surround each kidney?

A

Enclosed by a capsule (which also encloses the suprarenal glands)

Suprarenal glands separated from kidneys by a septum

All enclosed in perirenal fat and pararenal fascia

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3
Q

Label the lines according to the structures that overly the kidneys at each point

A

From top left anticlockwise:

Right suprarenal gland

Liver

Desc. Duodenum

R. Colic flexure

Small intestine

Jejunum

Desc. Colon

Left colic flexure

Pancreas

Spleen

Stomach

Left suprarenal gland

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4
Q

What are the posterior relations of the kidneys?

A

Left kidney

Top 1/3:

  • Rib XI and XII
  • Diaphragm

Lower 2/3 (From medial to laterally)

  • Psoas major
  • Quadratus lumborum
  • Transversus abdominis

Right Kidney:

  • As above but excluding Rib XI (R. Kidney lower)
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5
Q

Describe the Hilum of the Kidneys

A

Vertical clefts in the medial margins

Renal arteries, Veins and the ureters enter/leave here

VAU (vein, artery, ureter) Anterior to posterior

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6
Q

Describe the Venous drainage of the kidneys

What is the clinical relevance?

A

Renal veins drain both kidneys into the IVC

Left renal vein must cross the midline, lies between Superior mesenteric artery and the aorta

Clinical:

Aneurysm in the abdominal aorta could compress left renal vein

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7
Q

Describe the Renal arteries

What is the most common anomaly and the clinical significance of this anomaly?

A

Normally one renal artery to each kidney supplied by the Abdominal aorta

Right renal artery passes inferior to IVC

Multiple renal arteries to one kidney is a common anomaly

These multiple arteries are end arteries that do not anastomose and so occlusion of one will lead to kidney tissue ischaemia/necrosis

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8
Q

Label the black boxes

A

From top left anticlockwise:

Pyramid in renal medulla

Renal cortex

Renal papilla

Renal sinus

Minor calyx

Ureter

Renal Pelvis

Renal vein

Renal artery

Major Calyx

Renal Column

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9
Q

Through which structures does filtrate/urine pass in kidneys before reaching the bladder?

A

Filtrate in the cortex is filtered throught the nephrons to the collecting ducts in the medulla

Urine passes throught collecting ducts in the renal pyramids to the papillae at the apex of each pyramid

Papillae drain into minor calyx, which in turn drains into the major calyx

Major calices drain to the renal pelvis, then through the ureters to the bladder

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10
Q

Follow the course of a red blood cell from the left renal artery to the left renal vein

Hint: Make sure to go into detail of vasculature surrounding each nephron

A

Arterial:

Renal Vein

Segmental artery

Interlobar artery

Arcuate artery

Interlobular artery

Afferent arterioles

Glomerulur tuft

Efferent arteriole

THEN EITHER

Peritubular capillaries which drain into cortical venules

OR

Vasa recta, which drain into the venae recta

Venous:

Cortical venules or venae recta

Interlobular vein

Arcuate vein

Interlobar vein

Segmental vein

Renal vein

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11
Q

Where can the kidney recieve abberant blood supply from?

A

Extra renal arteries

Superior mesenteric artery

Suprarenal artery

Testicular or ovarian arteries

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12
Q

What 3 constrictions are present in the ureters as they travel from kidney to bladder?

A
  • The Junction of the renal pelvis
  • At pelvic brim
  • Where it pierces the bladder wall
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13
Q

At what level do the ureters cross the pelvic brim?

What is the closest major vasculare structure at this level?

A

At the level of the sacro-iliac joint

The ureter pasess anterior to the bifurcation of the common iliac artery at this level

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14
Q

Describe the course of the ureters from Hilum to Bladder

A

Descends anterior to psoas major

crosses pelvic brim at level of sacro-iliac joint

In Women:

Uterine artery passes over the ureter (water under the bridge)

In Men:

Ureter passes under the vas deferens

Then:

  • Ureters enter the posterolateral aspect of the bladder and run obliquely throught the bladder wall
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15
Q

Given the most likely cause of trauma to the ureters

A

During hysterectomy or oophorectomy in women damage to the ureters can occur

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16
Q

Apart from trauma, what is the other major clinical aspect of ureters? Explain in detail

A

Uretic stones can be passed from kidney

Can get caught at uretic constrictions causing renal colic

Smooth muscle spasms that are normally a function of peristalsis try to clear the stone

This can cause pain from visceral sensory nerves T11 to L2

This presents as groin, loin and flank pain

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17
Q

Givea a very brief description of bladder structure (3 points)

A

Hollow

Distensible (transitional epithelium)

Muscular walls

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18
Q

Where is the bladder found and how is it shaped?

Hint: Different states

A

Empty:

Lies in the lesser pelvis inferior to the peritoneum

It is a tetrahedron

Posterior base, superior side and two inferolateral sides

Full:

Rises into the greater pelvis and above the pubic bone, may reach as high as the umbilicus. Still lies inferior to peritoneum

Spherical in shape

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19
Q

Give short descriptions of the specific regions/structures of interest within the bladder (5 points)

A

Apex (anterior angle):

Connection here to urachus, seen as the median umbilical ligament

Trigone:

Defines posterior wall, oblique openings to the ureters and internal urethral opening in a triangle shape, smooth walled

Interureteric fold:

Ridge between two ureter openings

Neck:

Where base and inferolateral sides meet

Involuntary internal sphincter:

Circular region of detrusor muscle at neck acting as sphincter

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20
Q

Describe the bladder walls (3 points)

A

Rugae in mucosa except within trigone

Transitional epithelium

Detrusor muscle is the muscularis propria, formed of longitudinal, circular and oblique fibres

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21
Q

How is the prostate involved in urination?

A

Can occlude urethra preventing urination

Enlargement normal with age in response to male hormones

22
Q

How long is the urethra?

A

Females:

4-5cm

Males:

~20cm

23
Q

Describe the course of the male urethra

Include notes on structure in each section

A

Preprostatic:

Small section of urethral between bladder and prostate

Transitional epithelium

Prostatic:

Section of the urethra that passes through the prostate, ejaculatory duct and prostatic ducts drain into urethra here

Transitional epithelium

Membranous:

Small section of urethra passing through the external urethral sphincter and the deep peritoneal pouch

Stratified columnar epithelium

Spongy (Penile):

Longest section passes through the penis (corpus spongosium)

Stratified columnar proximally

Stratified squamous distally

24
Q

What is the clinical significance of the Membranous section of the male urethra

A

Can be damaged during catheterisation

25
Q

Describe the course of the female urethra

A

Passes between the glans clitoris and the vaginal opening

Passes through the deep perenial pouch first, this is where the external urethral sphincter resides

Then passes straight to the external urethral orifice

26
Q

What is the clincial relevance of the female urethra?

A

Greater chance of UTIs than men due to closeness to the anal orifice and short length

27
Q

What are the general functions of the kidneys? (4 points)

A

Regulation:

Controls concentrations og key substances (ions and small organic molecules) in ECF

Excretion:

Filters waste products from blood

Endocrine:

Synthesis of renin, erythropoietin, prostaglandins

Metabolism:

Produce active Vit. D

Catabolism of Insulin, PTH, calcitonin

28
Q

Describe the water content of a 70Kg Medical student

A

40L total

ICF:

25L

ECF:

Interstitial fluid - 12L

Intravascular - 3L

Lymph

Synovial, intestinal, CSF, Sweat, Urine, Pleural, Peritoneal, Pericardial, Intraocular

29
Q

Describe what is meant by the terms:

Osmolality

Osmolarity

Oncotic

A

Osmolality:

Solute per Kg of solvent

Osmolarity:

Number of osmoles (ions and organic molecules) of solute per litre

measured in milli-osmoles

Oncotic:

Osmotic force due to proteins

30
Q

How do you make water cross a cell membrane?

A

Have differnt osmolarities across the membrane

Water moves from areas of low to high osmolarity

31
Q

Compare the ICF and ECF in terms of relative amounts of electrolytes

Why are they different?

What can happen in the case of disturbance to this balance?

A

ECF:

High Na+ and low K+

Many large organic anions

ICF:

High K+ and low Na+

Main anions Cl- and HCO3-

Difference:

Maintained by active transport mechanisms

(E.g. Na+/K+ATPase)

Disturbance:

Failure to control electrolyte balance will affect transport and electrical functions

32
Q

How do the Kidney interact with bodily fluid?

A

Affects ECF directly by changing volume and compostion

This has indirect effect on the ICF

33
Q

How does failure of the kidney to regulate ECF volume and composition affect the body?

Hint: Keep it general

A

Volume:

Changes in BP, Tissue fluid and cell function

Composition:

Changes in osmolarity cause cells to shrink or swell

34
Q

What 2 major factors affect homeostatic regulation of ECF/ICF in a normal physiological state?

A

Variable ingestion of water and salts

Loss of water and salts

35
Q

How do the kidneys affect the acid/base balance of the body?

A

Control concentration of Bicarbonate in plasma

36
Q

How much does the kidney filter every minute/day and what is this called?

What is the general composition of this filtrate?

How much ends up being excreted?

A

125ml/min or 180L/day - Glomerular filtration rate

Produces an ultrafiltrate of water, ions and small molecules

Leaves on average 1.5L or urine a day

37
Q

What is the functional unit of the kidney?

How many are found in each kidney?

A

Nephron

1.5 million

38
Q

Give the basic areas of the nephron and where they are found

A

Cortex:

Glomerulus, PCT, DCT

Medulla:

Loop of Henle

Collecting duct (passes into pelvis)

39
Q

What is the function of epithelium in the nephron?

A

Filtration of plasma

Excrete waste produces

Reabsorb needed materials from ultrafiltrate

40
Q

1. Give a list of normal substances the kidney will reabsorb and proportions of that material that are reabsorbed from ultrafiltrate

2. Give an example of a substance that is actively excreted

A

1.

Water - 99% reabsorbed

Na+ and Cl- 99%

Bicarbonate - 100%

Gucose and amino acids -100%

2.

H+ actively excreted by epithelium (lose more than is filtered)

41
Q

What is the blood flow required by the kidney?

What proprtion of cardiac output does this represent?

A

4ml/g/min

25%

42
Q

Decribe in general terms how the kidney produces ultrafiltrate

A

Glomerulus filters water, ions and small molecules by constant filtration pressure in capillaries

Specialised circulation (affernet and efferent arterioles) maintains filtration pressure

43
Q

Describe the functions of the PCT

A

Major site of reabsorbtion:

60-70% water

80-90% Na+ and K+

90% Bicarbonate

100% glucose and AAs

Reabsorbed materials then leave via peritubular capillaries

44
Q

Is the fluid in the PCT hypotonic, isotonic or hypertonic?

Explain

A

Isotonic

Water follows osmotic gradient produces by reabsorbtion

45
Q

What is meant by ‘Kidney epithelia are polarised’

Why is this important

A

Polarisation:

Differnt membrane transporters on luminal and basolateral membranes

This allows transport across the epithelium

46
Q

Explain how Na+/K+ATPase transporters are involved in reabsorbtion at the PCT

A

Na+/K+ATPase extrudes Na+ across basolateral membrane

Na+ enters cells from lumen down conc gradient

Energy from soudium movement used to drive reabsorbtion of other sultutes such as glucose

Water follows osmotically

47
Q

What are the functions of the Loop of Henle?

A

Reabsorbtion:

Further reabsorption occurs

Counter current multiplication:

Creates a gradient of increasing osmolarity in the medulla

Allows formation of concentrated urine to conserve water

48
Q

Describe the modification of urine in the DCT

A

Site of variable reabsorbtion of electrolytes and water

Takes hypotonic fluid leaving LoH and removes yet more Na+ and Cl-

Actively secretes H+

Water can move into or out of lumen

If net movement is into the lumen then large volumes of dilute urine formed (Diuresis)

49
Q

Describe how the collecting duct affects urine production

A

Collecting duct passes through high osmolarity medulla

If CD is water permeable, water moves out and concentrated urine is produced

If CD not permeable to water, urine remains dilute

50
Q

Describe the hormonal basis of variable reabsorption in the distal nephron

A

Renin angiotensin system:

Controls sodium recovery and hence controls ECF volume/amount of water reabsorbed

Anti-Diuretic hormone:

Controls permeability of the DCT and collecting ducts

This controls ECF osmolarity