UNIT 8: ANTIPSYCHOTIC AND ANTIDEPRESSANT DRUGS

Question 1

Phenothiazines

Chemical Class:
Aliphatic

Answer 1

Chlorpromazine

Question 2

Phenothiazines

Chemical Class:
Piperazine

Answer 2

Fluphenazine

Question 3

Phenothiazines

Chemical Class:
Thioxanthene

Answer 3

Thiothiexene

Question 4

Phenothiazines

Chemical Class:
Butyrophenone

Answer 4

Haloperidol

Question 5

Phenothiazines

Chemical Class:
Dibenzodiazepine

Answer 5

Clozapine

Question 6

Phenothiazines

Chemical Class:
Benzisoxazole

Answer 6

Risperidone

Question 7

Phenothiazines

Chemical Class:
Thienobenzodiazepine

Answer 7

Olanzapine

Question 8

Phenothiazines

Chemical Class:
Dibenzothiazepine

Answer 8

Quetiapine

Question 9

Phenothiazines

Chemical Class:
Dihydroinolone

Answer 9

Ziprasidone

Question 10

Phenothiazines

Chemical Class:
Dihydrocarbostyril

Answer 10

Aripriprazole

Question 11

Phenothiazines

Chemical Class (Drug) with a very high D2/5-HT2A ratio

Answer 11

Chemical Class: Thioxanthene
Drug: Thiothiexene

Question 12

Phenothiazines

Chemical Class (Drug) with very high extrapyramidal toxicity

Answer 12

Chemical Class: Butyrophenone
Drug: Haloperidol

Question 13

Piperazine derivative that’s as effective as atypical antipsychotic drugs

Answer 13

Perphenazine

Question 14

Enzymes affected by lithium at therapeutic concentrations

Rate-limiting enzyme in inositol recycling
Inhibited by lithium, resulting in depletion of substrate for IP3 production

Answer 14

Inositol monophosphatase
Inositol polyphosphatase 1-phosphatase

Question 15

Enzymes affected by lithium at therapeutic concentrations

Involved in AMP production
Results in lithium-induced nephrogenic diabetes insipidus

Answer 15

Biphosphate nucleotidase

Question 16

Enzymes affected by lithium at therapeutic concentrations

Involved in gluconeogenesis

Answer 16

Fructose 1,6-biphosphatase

Question 17

Enzymes affected by lithium at therapeutic concentrations

Involved in glycogenolysis

Answer 17

Phosphoglucomutase

Question 18

Enzymes affected by lithium at therapeutic concentrations

Constitutively active enzyme that appears to limit neurotrophic and neuroprotective processes

Answer 18

Glycogen synthase kinase-3

Question 19

Enzymes affected by lithium at therapeutic concentrations (6)

Answer 19

Inositol monophosphatase
Inositol polyphosphate 1-phosphatase
Biphosphate nucleotidase
Fructose 1,6-biphosphatase
Phospoglucomutase
Glycogen synthase kinase-3

Question 20

First used therapeutically in the mid-19th century in patients with gout

Answer 20

Lithium

Question 21

Briefly used a substitute for sodium chloride in hypertensive patients in the 1940s

Answer 21

Lithium

Question 22

An effective treatment for bipolar disorder (manic phase)

Answer 22

Lithium

Question 23

Enumeration

Thiothixene

Answer 23

Haloperidol

Question 24

Similar to phenothiazines
Used in schizoprenia
Less risk of tardive dyskinesia

Answer 24

Thiothixene

Question 25

Thioxanthene

Block of D2 receptors&raquo_space; 5-HT2 receptors

Answer 25

Phenothiazenes (Chlorpromazine, Fluphenazine, Thioridazine)
Haloperidol

Question 26

Used for Schizoprenia, bipolar disorder (manic phase), Huntington chorea, Tourette syndrome

Answer 26

Haloperidol

Question 27

Used for Schizoprenia, Bipolar disorder (manic phase), Antiemesis, and Preop sedation

Answer 27

Chlorpromazine
Fluphenazine
Thioridazine

Phenothiazines

Question 28

Block of 5-HT2 receptors&raquo_space; D2 receptors

Answer 28

Second generation antipsychotics and bipolar disorder agents