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PCOL MIDTERMS > UNIT 8: ANTIPSYCHOTIC AND ANTIDEPRESSANT DRUGS > Flashcards

UNIT 8: ANTIPSYCHOTIC AND ANTIDEPRESSANT DRUGS Flashcards

1
Q

Phenothiazines

Chemical Class:
Aliphatic

A

Chlorpromazine

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2
Q

Phenothiazines

Chemical Class:
Piperazine

A

Fluphenazine

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3
Q

Phenothiazines

Chemical Class:
Thioxanthene

A

Thiothiexene

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4
Q

Phenothiazines

Chemical Class:
Butyrophenone

A

Haloperidol

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5
Q

Phenothiazines

Chemical Class:
Dibenzodiazepine

A

Clozapine

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6
Q

Phenothiazines

Chemical Class:
Benzisoxazole

A

Risperidone

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7
Q

Phenothiazines

Chemical Class:
Thienobenzodiazepine

A

Olanzapine

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8
Q

Phenothiazines

Chemical Class:
Dibenzothiazepine

A

Quetiapine

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9
Q

Phenothiazines

Chemical Class:
Dihydroinolone

A

Ziprasidone

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10
Q

Phenothiazines

Chemical Class:
Dihydrocarbostyril

A

Aripriprazole

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11
Q

Phenothiazines

Chemical Class (Drug) with a very high D2/5-HT2A ratio

A

Chemical Class: Thioxanthene
Drug: Thiothiexene

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12
Q

Phenothiazines

Chemical Class (Drug) with very high extrapyramidal toxicity

A

Chemical Class: Butyrophenone
Drug: Haloperidol

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13
Q

Piperazine derivative that’s as effective as atypical antipsychotic drugs

A

Perphenazine

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14
Q

Enzymes affected by lithium at therapeutic concentrations

Rate-limiting enzyme in inositol recycling
Inhibited by lithium, resulting in depletion of substrate for IP3 production

A

Inositol monophosphatase
Inositol polyphosphatase 1-phosphatase

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15
Q

Enzymes affected by lithium at therapeutic concentrations

Involved in AMP production
Results in lithium-induced nephrogenic diabetes insipidus

A

Biphosphate nucleotidase

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16
Q

Enzymes affected by lithium at therapeutic concentrations

Involved in gluconeogenesis

A

Fructose 1,6-biphosphatase

17
Q

Enzymes affected by lithium at therapeutic concentrations

Involved in glycogenolysis

A

Phosphoglucomutase

18
Q

Enzymes affected by lithium at therapeutic concentrations

Constitutively active enzyme that appears to limit neurotrophic and neuroprotective processes

A

Glycogen synthase kinase-3

19
Q

Enzymes affected by lithium at therapeutic concentrations (6)

A

Inositol monophosphatase
Inositol polyphosphate 1-phosphatase
Biphosphate nucleotidase
Fructose 1,6-biphosphatase
Phospoglucomutase
Glycogen synthase kinase-3

20
Q

First used therapeutically in the mid-19th century in patients with gout

A

Lithium

21
Q

Briefly used a substitute for sodium chloride in hypertensive patients in the 1940s

A

Lithium

22
Q

An effective treatment for bipolar disorder (manic phase)

A

Lithium

23
Q

Enumeration

Thiothixene

A

Haloperidol

24
Q

Similar to phenothiazines
Used in schizoprenia
Less risk of tardive dyskinesia

A

Thiothixene

25
Q

Thioxanthene

Block of D2 receptors&raquo_space; 5-HT2 receptors

A

Phenothiazenes (Chlorpromazine, Fluphenazine, Thioridazine)
Haloperidol

26
Q

Used for Schizoprenia, bipolar disorder (manic phase), Huntington chorea, Tourette syndrome

A

Haloperidol

27
Q

Used for Schizoprenia, Bipolar disorder (manic phase), Antiemesis, and Preop sedation

A

Chlorpromazine
Fluphenazine
Thioridazine

Phenothiazines

28
Q

Block of 5-HT2 receptors&raquo_space; D2 receptors

A

Second generation antipsychotics and bipolar disorder agents

PCOL MIDTERMS (10 decks)

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