Unit 8 Flashcards
onc/o
tumors
infiltrative
tumor extends into adjacent healthy tissue
meta
beyond, change
Metastasis
tumor cells spread from one part or organ to another not directly connected with it
ana
backward
dedifferentiation / anaplasia
malignant cells go back to embryonic cells
encapsulated
benign tumors are
histogenesis
formation and differentiation of tissue from undifferentiated cells
adenomas
Benign tumors that arise from epithelial cells
adenocarcinoma
cancerous tumor of an epithelium that originates in glandular tissue
Sarcomas
originate in connective tissue
sarc/o
connective tissue
glioma
Cancer in the connective tissue in the brain
neuroblastoma
childhood cancer arising from immature tissues in the autonomic nervous system
mixed-tissue tumors
sites of development are kidneys, ovaries, and testes
apoptosis
cell death
carcinogenesis
development of cancer, from mutations
mut/a
genetic change
mutation
stimulate cell growth or block DNA repair lead to the formation of malignant tumors
types of carcinogen
radiation, oncogenic viruses, toxic chemicals
oncogenic viruses
RNA viruses / retroviruses and DNA viruses
oncogene
a piece of DNA whose activation is associated with the conversion of normal cells into cancerous cells
guaiac fecal occult blood test (gFOBT)
presence of fecal occult blood (FOB) can indicate colorectal cancer
estrogen (estradiol) receptor assay
pinpoints the tumor’s receptivity to estrogen
protein marker tests
measure tumor-generated proteins, or protein markers, which are present in the bloodstream
CA-125 test and the CEA test
detects carcinoembryonic antigen (CEA)
Acid phosphatase test and the prostate-specific antigen (PSA) test
test for prostate cancer
Beta-hCG test, which is used to detect the presence of human chorionic gonadotropin (hCG) in serum
for testicular cancer
Alpha-fetoprotein test
for testicular and liver cancers
Cytogenetic analysis
for leukemia and other cancer
Immunohistochemistry (IHC)
localizes antigens or proteins in tissues using marked antibodies to assess the presence and amount of specific molecules in both normal and tumor cells
fine-needle aspiration (FNA) biopsy
aspirating free cells from a fluid-filled cavity or from inside a solid tumor mass using a fine needle
thoracocentesis
surgical puncture with the insertion of a needle or catheter into the pleural space to obtain pleural fluid for analysis
liquid biopsy
looks for cancer cells or tumor cell DNA in a blood sample
Papanicolaou test
Pap smear (exfoliative cytology)
radionuclide scans
radioactive substances that are intravenously injected can detect tumors and metastases
bone scan
injecting a radioactive phosphate substance, called a radionuclide, to see areas of uptake
thallium-201
used to detect head and neck tumors
needle used in core-biopsy
large-bore
cachexia
most severe form of malnutrition associated with cancer
cac/o
bad
-hexia
state of condition
fungating tumors
mushrooming pattern of growth
colon
cystic tumors
mucinous or serous
ovaries
medullary tumor
large, soft, and fleshy
breast or thyroid gland
verrucous tumor
wartlike pattern
gingiva or cheek
polypoid
projection-like growths that extend outward from a base
sessile polypoid tumor extends from a broad base (sessile = having no stem). The pedunculated polypoid tumor
colon
inflammatory tumor
inflamed
tumor blocks the skin’s lymphatic drainage
necrotic tumor
contains dead tissue
ulcerating tumor
exhibits an exposed surface from the death of overlying tissue
dysplasia
abnormality in cellular development
Carcinoma in situ
tumor cells are cancerous but have not yet invaded adjacent structures
diffuse tumor growth
cancer has clearly spread evenly throughout the affected tissue
Alveolar tumor cells
form patterns that resemble small, microscopic sacs
muscle, bone, fat, and cartilage
epidermoid cells
respiratory tract
follicular tumor cells
thyroid gland cancer and can form glandular sacs of their own
Nodular cells
seen in malignant lymphomas when lymph node involvement is extensive
Papillary cells
fingerlike or nipplelike projections
bladder
pleomorphic
cellular level, a mixed-cell tumor
morph/o
shape/form
scirrhous tumor
densely packed and overgrown with fibrous tissue
breast and stomach cancers
scirrh/o
hard
Grading
based on the microscopic appearance of the tumor cells
looks for the degree of maturation or differentiation
grades 1-4
Staging
extent of metastasis
TNM
tumor, nodes, and metastases
Duke staging system
staging colon cancer and hereditary nonpolyposis colon cancer (HNPCC)
excisional biopsy
removal of the tumor, along with a margin of normal tissue
incisional biopsy
removal of a piece of the tumor for diagnosis and may be followed by additional treatment to remove the bulk of the tumor
resection/exenteration
not only the removal of the tumor but also its original site and the surrounding tissue in the body space
En bloc resection
removal of the tumor along with a large area of the surrounding tissue and usually lymph node removal as well
ex: mastectomy, colectomy, and gastrectomy
cryosurgery
subfreezing temperature is used to destroy the malignant tumor
cauterization
destroys the tumor by burning it
fulguration
destroy abnormal tissue is with the use of electric sparks generated by a high-frequency current
debulking procedure
used if the tumor is attached to a vital organ and cannot be completely removed
Bone marrow transplant (BMT)
procedural intervention
radiation therapy (RT) / radiation oncology
delivering a maximum dose of ionizing radiation to tumor tissue
intraoperative radiation therapy (IORT)
RT used before or after surgery
fibrosis
increase in connective tissue in normal tissue caused by too much radiation
gray (Gy) (absorbed radiation dose)
unit of measurement for radiation
Pneumonitis
Inflammation in the lungs
Myelosuppression
Bone marrow depression
Anemia and Thrombocytopenia
Mucositis
Inflammation and ulceration of mucous membranes
Xerostomia
Dryness of the mouth
Alopecia
Partial or complete hair loss
Secondary tumors
New types of tumors originating at a site separate from the primary tumor
fractionation
radiation is delivered in small, repeated doses rather than in fewer large doses
brachytherapy
limits exposure by directly implanting seeds of radioactive material into a tumor (interstitial therapy) or into the cavity of a tumor (intercavitary therapy
external beam radiation (teletherapy)
applied to the tumor from a distant source outside the body—namely, a linear accelerator
radiocurable
completely eradicated (cured) by radiation therapy
lymphoma
Radiosensitive tumors
tumors in which radiation can cause the death of cells without serious damage to surrounding tissue
PSRS (gamma knife surgery)
proton stereotactic
radioresistant
require large doses of radiation to produce cell death
radiosensitizers
drugs that increase the tumor’s sensitivity to x-rays
Chemotherapy
uses drugs or chemicals to damage the DNA of cancer cells
pharmacokinetics
measure how quickly drugs disappear from the bloodstream and tissues and investigate drug routes
protocol
treatment plan
remission
partial or complete disappearance of the signs of the disease
NED
no evidence of disease
Alkylating agents
Attack DNA molecules, causing strand breaks
Antibiotics
Promote breakage of the DNA strands, preventing their replication
Antimetabolites
Inhibit synthesis of DNA components, or block DNA replication
Antimitotics
Block mitosis
Molecularly targeted therapy
Blocks the function of growth factors, their receptors, and signaling pathways in tumor cells
hormonal agents
Hormones attach to receptor proteins in target tissues and can have growth-inhibiting effects on certain types of cancer
leukemia and breast cancer
immunotherapy
use immune cells and antibodies to fight tumor cells.
chimeric antigen receptor T cell (CAR T) therapy
T cells are extracted from the patient’s blood and modified
acute lymphoid leukemia (ALL) and chronic lymphoid leukemia (CLL)
monoclonal antibodies
kill tumors by blocking growth receptors on the tumor cell surface
Clinical trials
research studies designed to test the risks and efficacy of new drugs
palliative care
relieve symptoms
Adjuvant chemotherapy
Adding drugs early in the course of treatment to hasten or assist primary treatment in attacking cancer cells
Undifferentiated
Lacking structures typical of mature cells
needle biopsy
aspiration of a core of tissue for microscopic examination
dysplastic
Abnormal but not clearly cancerous
follicul/o
Small glandular sacs
x-ray
electromagnetic radiation
properties of x-rays
Causes exposure of a photographic plate
Penetrates different substances to varying degrees
Travels in straight lines
Ionization
invisibility and scattering
radiolucent
Substances that are less dense and permit the passage of x-ray beams
-lucent
to shine
radiopaque
dense surfaces that absorb x-rays
opaque
obscure
film badge
monitoring device used to detect radiation exposure
Diagnostic radiography
visualization of the body’s structures using radiation from external sources
Digital radiography
digital x-ray sensors are used instead of traditional photographic film
Nuclear medicine
relies on radioactive substances that are placed within the body or added to laboratory specimens
Radiation therapy / oncology
treat cancer
AP
anteroposterior
PA
posteroanterior
LAT
lateral projection (one side to other)
oblique
patient at an angle
recumbent
lying down
decubitus (decub) position
patient lies on the right or left side
tom/o
to cut
MDCT
multidetector CT
contrast agent / contrast medium
substance, either radiopaque or radiolucent, that is introduced into the body to cause structures to appear lighter or darker
types of contrast agents
barium (Ba) sulfate, iodine, and nitrogen gas
barium swallow
upper GI tract
barium enema (BE)
rectal administration of barium sulfate for large intestine
DSA
digital subtraction angiography
Cholangiography
outline the major bile ducts with iodine
percutaneous transhepatic cholangiography.
iodine administered through skin or liver
pyelography (urograms)
renal pelvis and urinary tract with iodine
intravenous pyelogram (IVP)
iodine administered through vein
retrograde pyelogram
iodine administered through urethra and bladder