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Pharmacology > Unit 5-Steroids > Flashcards

Unit 5-Steroids Flashcards

1
Q

Cortisol, Cortisone acetate, hydrocortisone, prednisone, prednisolone, methylprednisolone, triamcinolone, dexamethasone

Mechanism

A

Binds GR, which regulates expression of genes with many effects on carbohydrate metabolism and immune function

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2
Q

Cortisol, Cortisone acetate, hydrocortisone, prednisone, prednisolone, methylprednisolone, triamcinolone, dexamethasone

Side effects

A

Cushing’s; glucocorticoid-induced osteoporosis; iatrogenic adrenal insufficiency

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3
Q

Hydrocortisone

Uses

A

Chronic primary adrenal insufficiency (maintenance); CAH

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4
Q

Prednisone

Uses

A

CAH

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5
Q

Dexamethasone

Uses

A

Emergency treatment (severe adrenal crisis, PAI); suppression test (Cushing’s); CAH

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6
Q

Fludrocortisone

Drug class

A

Mineralocorticoid

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7
Q

Fludrocortisone

Mechanism

A

Binds aldosterone receptor (AR) which increases Na+K+ATPase expression and increase epithelial sodium channel experession

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8
Q

Fludrocortisone

Uses

A

Chronic primary adrenal insufficiency (maintenance); CAH

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9
Q

Fludrocortisone

Side effects

A

Primary aldosteronism

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10
Q

Aminoglutethide

Mechanism

A

Blocks conversion of cholesterol to pregnenolone

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11
Q

Aminoglutethide

Uses

A

Cushing’s

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12
Q

Ketoconazole

Drug class

A

Anti-fungal imidazole derivitive

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13
Q

Ketoconazole

Mechanism

A

Potent, nonselective inhibitor of adrenal and gonadal steroid synthesis

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14
Q

Ketoconazole

Uses

A

Cushing’s

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15
Q

Mitotane

Drug class

A

DDT insecticide relative

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16
Q

Mitotane

Mechanism

A

Nonselective cytotoxic action on adrenal cortex

17
Q

Mitotane

Uses

A

Cushing’s

18
Q

Mitotane

Side effects

A

Bad side effect profile

19
Q

Metyrapone

Mechanism

A

Relatively selective inhibitor of 11-hydroxylation (interferes with cortisol and corticosterone synthesis)

20
Q

Metyrapone

Uses

A

Cushing’s

21
Q

Mifepristone (RU-486)

Mechanism

A

Progesterone receptor antagonist; GR antagonist at high concentrations

22
Q

Mifepristone (RU-486)

Uses

A

Cushing’s (controls hyperglycemia secondary to hypercortisolism)

23
Q

Mifepristone (RU-486)

Side effects

A

Fatigue, nausea, headache, hypokalemia, arthralgias

edema and endometrial thickening in women

24
Q

Pasireotide

Drug class

A

somatostatin analog

25
Q

Pasireotide

Mechanism

A

Binds to somatostatin receptor and blocks release of ACTH from corticotropes

26
Q

Pasireotide

Uses

A

Cushing’s

27
Q

Pasireotide

Side effects

A

Hyperglycemia, GI problems

28
Q

Spironolactone

Mechanism

A

Aldosterone receptor antagonist

29
Q

Spironolactone

Uses

A

Primary aldosteronism

30
Q

Spironolactone

Side effects

A

Anti-androgenic

31
Q

Eplerenone

Mechanism

A

Aldosterone receptor antagonist

32
Q

Eplerenone

Uses

A

Primary aldosteronism

More specific; less anti-androgenic effect than spironolactone

Pharmacology (26 decks)

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