unit 3 vocab Flashcards

Basic Hemostasis

1
Q

adhesion

A

the act of two parts or surfaces sticking together

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2
Q

aggregation

A

/ the collecting of separate objects into one mass

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3
Q

arteriosclerosis

A

abnormal thickening and hardening of the arterial walls, causing loss of elasticity
and impaired blood circulation

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4
Q

atherosclerosis

A

a form of arteriosclerosis in which lipids, calcium, cholesterol, and other substances deposit
on the inner walls of the arteries

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5
Q

coagulation

A

/ the process of forming a fibrin clot

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6
Q

coagulation factors /

A

a group of plasma proteins (and the mineral calcium) involved in blood clotting

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7
Q

collagen

A

/ a protein connective tissue found in skin, bone, ligaments, and cartilage

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8
Q

Coumadin

A

/ an anticoagulant drug derived from coumarin that is administered orally to prevent blood clotting
or to reduce the risk of clots; a trade name for warfarin

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9
Q

D-dimer

A

/ the smallest cross-linked fibrin degradation fragment formed from the breakdown of polymerized
fibrin by plasmin

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10
Q

embolus (pl. emboli)

A

a mass (clot) of blood or foreign matter carried in the circulation

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11
Q

endothelium

A

/ the layer of epithelial cells that lines blood vessels and the serous cavities of the body

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12
Q

FDPs

A

fibrinogen or fibrin monomer degradation products formed when plasmin cleaves fibrinogen or fibrin
monomers into protein fragments; formerly called fibrin split products

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13
Q

fibrin

A

a protein formed from fibrinogen by the action of thrombin

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14
Q

fibrinogen

A

a plasma protein produced in the liver and converted to fibrin through the action of thrombin

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15
Q

fibrinolysis

A

enzymatic breakdown of a blood clot

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16
Q

glycoprotein

A

a protein molecule having a carbohydrate component

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17
Q

hemorrhage

A

/ uncontrolled bleeding

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18
Q

hemostasis

A

/ the process of stopping bleeding, which includes clot formation and dissolution

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19
Q

heparin

A

/ an anticoagulant used therapeutically to prevent thrombosis; also used as an anticoagulant in certain
laboratory procedures

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20
Q

inhibitor

A

a substance that retards or stops a process or chemical reaction

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21
Q

intravascular

A

/ within the blood vessels

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22
Q

ionized calcium

A

/ in the body, a mineral that plays an important role in hemostasis

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23
Q

megakaryocyte

A

a large bone marrow cell from which platelets are derived

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24
Q

plasmin

A

an enzyme that binds to fibrin and initiates breakdown of the fibrin clot (fibrinolysis)

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25
Q

plasminogen

A

the inactive precursor of plasmin

26
Q

prothrombin

A

the precursor of thrombin; factor II

27
Q

sequestered

A

/ isolated or set apart from the whole

28
Q

thrombin

A

a protein formed from prothrombin by the action of thromboplastin and other factors in the presence
of calcium ions; factor IIa

29
Q

thromboplastin

A

a lipoprotein found in endothelium and other tissue; coagulation factor III; also called
tissue factor

30
Q

thrombus (pl. thrombi)

A

a blood clot that obstructs a blood vessel

31
Q

vasoconstriction

A

narrowing of the diameter of a blood vessel

32
Q

warfarin

A

an anticoagulant drug taken to prevent blood clotting or to reduce the risk of clots

33
Q

XDPs

A

degradation products formed by plasmin action on cross-linked fibrin and containing the
D-dimer fragment

34
Q

disseminated intravascular coagulation (DIC)

A

a bleeding disorder characterized by widespread thrombotic
and secondary fibrinolytic reactions

35
Q

epistaxis

A

nosebleed

36
Q

hemophilia

A

/ a bleeding disorder resulting from a hereditary coagulation factor deficiency
or dysfunction

37
Q

immune thrombocytopenic purpura (ITP)

A

/ a blood disorder characterized by purpura in skin and mucous
membranes and low platelet count caused by the destruction of platelets by antiplatelet autoantibodies;
also called idiopathic thrombocytopenic purpura

38
Q

NSAIDs

A

acronym for nonsteroidal anti-inflammatory drugs

39
Q

petechiae

A

small, purplish hemorrhagic spots on the skin; very small purpura

40
Q

purpura

A

purple-colored areas that can occur in the skin, mucous membranes, or organs and that are caused
when small blood vessels leak

41
Q

recombinant

A

referring to molecules or cells created as a result of genetic engineering

42
Q

thrombocytopathy

A

abnormal platelet function

43
Q

thrombotic thrombocytopenic purpura (TTP)

A

a blood disorder with varied causes and characterized by
formation of clots in the small vessels, consumption of platelets, and skin purpura

44
Q

von Willebrand’s disease (vWD)

A

/ an inherited platelet disorder associated with decreased platelet adhesion and
a bleeding tendency

45
Q

activated clotting time (ACT)

A

a test that assesses the effect of heparin on the ability of blood to clot

46
Q

heparin

A

a test that assesses the effect of heparin on the ability of blood to clot

47
Q

enzyme

A

/ a protein that causes or accelerates changes in other substances without being changed itself

48
Q

hypercoagulation

A

a greater tendency than normal for blood to coagulate

49
Q

international normalized ratio (INR)

A

/ a way of reporting a prothrombin time that takes into consideration
the sensitivity of the prothrombin thromboplastin reagent used and the mean prothrombin time
of a normal population

50
Q

international sensitivity index (ISI)

A

a value assigned to each lot of prothrombin thromboplastin reagent to
compensate for variations in sensitivities of thromboplastin from different sources

51
Q

prothrombin ratio

A

a comparison of a patient’s prothrombin time result with the mean prothrombin time of a
normal population

52
Q

prothrombin time test

A

a coagulation screening test used to monitor oral anticoagulant therapy

53
Q

vitamin k

A

/ a vitamin essential for production of coagulation factors II, VII, IX, and X

54
Q

activated partial thromboplastin time (APTT)

A

the time required for a fibrin clot to form when CaCl2 is
added to citrated plasma that has been activated with partial thromboplastin reagent

55
Q

partial thromboplastin

A

the lipid portion of thromboplastin, available as a commercial preparation; formerly
called cephaloplastin

56
Q

D-dimer

A

the smallest cross-linked fibrin degradation fragment formed from the breakdown of polymerized
fibrin by plasmin

57
Q

deep vein thrombosis (DVT)

A

/ occurrence of a thrombus within a deep vein, usually of the leg or pelvis

58
Q

disseminated intravascular coagulation (DIC)

A

a hemostasis emergency characterized by widespread
circulatory thrombotic events coexisting with fibrinolytic event

59
Q

FDPs

A

fibrinogen or fibrin degradation products formed when plasmin cleaves fibrinogen or fibrin monomers
into protein fragments; formerly called fibrin split products

60
Q

pulmonary embolism (PE)

A

occlusion of a pulmonary artery or one of its branches, usually caused by an
embolus that originated in a deep vein of the leg or pelvis

61
Q

sepsis

A

the presence of microorganisms and/or their toxic products in the blood or other tissues

62
Q

XDPs

A

degradation products formed by plasmin action on cross-linked fibrin and containing the D-dimer
fragment