Unit 3 Topic 1

Question 1

What is the action of primary lymphatic organs?

Answer 1

produces a variety of receptors via an antigen-independent process

Question 2

What do primary lymphatic organs do?

Answer 2

selection against those that recognize self or do not function via apoptosis

Question 3

What is the action of secondary lymphatic organs?

Answer 3

activate/differentiate naive cells into effector B and T lymphocyte

Question 4

What lymphatic organ activates cells through antigenic exposure?

Answer 4

secondary lymphatic organs

Question 5

What does the stimulation of cells in secondary lymphattic organs?

Answer 5

results in division and colonel selcection

Question 6

What is a fully mature T cell?

Answer 6

travel in the blood from thymus to secondary lymphatic organs where they are activated by foreign antigens presented by APC’s to from mature effector T cells

Question 7

How do T cells development?

Answer 7

-lymphoid stem cell progentior travels from the BM to the thymus, then migrates to subcapsular region of the cortex

Question 8

How are T cells education?

Answer 8

TCR recognizes MHC, but does not respond to self-antigens presented by MHC survive, mature, and enter blood

Question 9

What is contained in the blood thymus barrier?

Answer 9

-capillary endothelial cells with basal lamina
-connective tissue with macrophages
-epithelial reticular cells with basal lamina

Question 10

What is the purpose of the blood thymus barrier?

Answer 10

-required for selection and maturation of thymocytes
-blood thymus barrier prevents foreign antigens from reaching thymocytes

Question 11

What prevents foreign antigens from reaching thymocytes?

Answer 11

blood thymus barrier

Question 12

How are B cell educations?

Answer 12

makes a single unique antibody type due to genetic program that causes somatic gene rearragement

Question 13

What generates diversity in B cells?

Answer 13

B cell education

Question 14

What do mature naive B cells express IgD and IgM bind to and travel through?

Answer 14

they travel in the blood in secondary organs to differentiate into memory and plasma cells

Question 15

What does class switching allow B cells and plasma cells synthesize?

Answer 15

secrete IgA, IgG, and IgE antibodies (not just IgM and IgD)

Question 16

What filters lymph and what is lymph?

Answer 16

-lymph nodes
-lymph fluid and cells

Question 17

What eliminates pathogens and response to antigens entering though skin or mucosa?

Answer 17

lymph nodes

Question 18

What presents antigen by dendritic cells and macrophages?

Answer 18

lymph nodes

Question 19

What is the structure of a lymph node?

Answer 19

connective tissue capsule with an incomplete septa (trabeculae)

Question 20

Stroma

Answer 20

reticular cells synthesize and house network of reticular fibers

Question 21

What is in the cortex of the lymph node?

Answer 21

lymphatic nodules

Question 22

What is in the deep cortex of a lymph node?

Answer 22

primarily T cells

Question 23

What is in the medulla of a lymph node?

Answer 23

cords, enriched in plasma cells (antibody production), and sinuses enriched in phagocytes (pathogen clearance)

Question 24

Where are the high endothelial venules located?

Answer 24

deep cortex

Question 25

What moves lymphocytes and is where T cells enter circulation?

Answer 25

high endothelial venules

Question 26

Does spleen have cortex or medulla?

Answer 26

no

Question 27

What region of the spleen filters blood, houses splenic sinuses and splenic cords, and numerous macrophages found in cords?

Answer 27

Red pulp

Question 28

What region of the spleen immune response, B cell differentiation, periarterial lymphatic sheath with lymphocytes around a central artery?

Answer 28

white pulp

Question 29

What organ filters blood?

Answer 29

spleen

Question 30

What organ eliminates pathogen, old or damaged erythrocytes, and immune response to blood-borne antigens?

Answer 30

spleen

Question 31

What presents antigens in the spleen?

Answer 31

dendritic cells and macrophages