Unit 3 Topic 1 Flashcards
What is the action of primary lymphatic organs?
produces a variety of receptors via an antigen-independent process
What do primary lymphatic organs do?
selection against those that recognize self or do not function via apoptosis
What is the action of secondary lymphatic organs?
activate/differentiate naive cells into effector B and T lymphocyte
What lymphatic organ activates cells through antigenic exposure?
secondary lymphatic organs
What does the stimulation of cells in secondary lymphattic organs?
results in division and colonel selcection
What is a fully mature T cell?
travel in the blood from thymus to secondary lymphatic organs where they are activated by foreign antigens presented by APC’s to from mature effector T cells
How do T cells development?
-lymphoid stem cell progentior travels from the BM to the thymus, then migrates to subcapsular region of the cortex
How are T cells education?
TCR recognizes MHC, but does not respond to self-antigens presented by MHC survive, mature, and enter blood
What is contained in the blood thymus barrier?
-capillary endothelial cells with basal lamina
-connective tissue with macrophages
-epithelial reticular cells with basal lamina
What is the purpose of the blood thymus barrier?
-required for selection and maturation of thymocytes
-blood thymus barrier prevents foreign antigens from reaching thymocytes
What prevents foreign antigens from reaching thymocytes?
blood thymus barrier
How are B cell educations?
makes a single unique antibody type due to genetic program that causes somatic gene rearragement
What generates diversity in B cells?
B cell education
What do mature naive B cells express IgD and IgM bind to and travel through?
they travel in the blood in secondary organs to differentiate into memory and plasma cells
What does class switching allow B cells and plasma cells synthesize?
secrete IgA, IgG, and IgE antibodies (not just IgM and IgD)
What filters lymph and what is lymph?
-lymph nodes
-lymph fluid and cells
What eliminates pathogens and response to antigens entering though skin or mucosa?
lymph nodes
What presents antigen by dendritic cells and macrophages?
lymph nodes
What is the structure of a lymph node?
connective tissue capsule with an incomplete septa (trabeculae)
Stroma
reticular cells synthesize and house network of reticular fibers
What is in the cortex of the lymph node?
lymphatic nodules
What is in the deep cortex of a lymph node?
primarily T cells
What is in the medulla of a lymph node?
cords, enriched in plasma cells (antibody production), and sinuses enriched in phagocytes (pathogen clearance)
Where are the high endothelial venules located?
deep cortex
What moves lymphocytes and is where T cells enter circulation?
high endothelial venules
Does spleen have cortex or medulla?
no
What region of the spleen filters blood, houses splenic sinuses and splenic cords, and numerous macrophages found in cords?
Red pulp
What region of the spleen immune response, B cell differentiation, periarterial lymphatic sheath with lymphocytes around a central artery?
white pulp
What organ filters blood?
spleen
What organ eliminates pathogen, old or damaged erythrocytes, and immune response to blood-borne antigens?
spleen
What presents antigens in the spleen?
dendritic cells and macrophages
