Unit 3 key words Flashcards
Histones
protein that contains a genome
Nucleosomes
8 histones + 146 bp / coiled histones
genome
A haploid set of chromosomes in a microorganism
Cell division
Where 1 cell splits into two identical daughter cells
Daughter cells
Cells that come from 1 single parent cell
Chromosomes arm
The second half and a bigger part of a whole chromosome
G1
-cell increases
-increase in # of ribosomes
G2
Organelles will replicate
Final stage
S
DNA replication
Interphase
Where chromosomes duplicate and cell parts are made
Miotic phase / M phase
Where cell division occurs
Biochemical activity
The way the body converts food into energy
Sister chromatids
2 identical chromatids formed by the replication of chromosomes
Cohesions
sticking of particles
Centrosome
Organelle that regulates cell mobility
Aster
radical array of short microtubules
Nonkinetochore
don’t attach to the centromere
Miotic phase
where single parent makes daughter cells
prophase
the first stage of mitosis
Anaphase
¨apart¨, sister chromosomes separate and move along the kinetochore
separase
protein that helps with chromosome segragation
Depolymerizing
cell has a shift in electric charge distributin
Nuclear envolope
Organelle that separates the nucleus and cytoplasm in euk. cells
Nucleolus
organelle that surrounds the nucleus
Telophase
¨opposite of prophase¨ daughter cells are about to separate
Kinetochore
attach to centromere
Haploid
cell that has a single set of chromosomes
Diploid
cell that has 2 sets of chromosomes
Cytokinesis
splitting the cell
Karyokinesis
splitting the nucleus
Golgi Complex
stack of small flat sacs (can look it up to see),prepares molecules to go in or out the cell
Cell plate
a structure that forms when the cytoplasm of a plant cell divides (imagine a line separating a cell)
Cdk
regulatory control of cell cycle -
Cell Wall
covers the outermost of the cell
density-independent inhibition
occurs when cells grow to a limited density then growth becomes inhibited
Cylin
cycles /regulatory control of cell cycle
Differentation
selective gene expression
G0
phase where nothing happens
Cancer
runaway cellular division
proto-oncogenes
normal genes which affect normal cell growth and proliferation,
sexual reproduction
genetic variability
meiosis
chromosome # is reduced by 1/2
fertilization
fusion of male and female sex cells(gametes)
2n
Diploid
n
Haploid
Gamete
Any haploid cell capable of fusing w/ another haploid cell to form a new idv.
Homologous chromosomes
Structurally identical chromosomes
genetic variability
Each cell contains new combinations of chromosomes
Meiosis 1
type of cell division, G1 S G2 phases occurs here
Prophase 1
the first meiotic division
tetrads
consist of two homologous chromosomes, with a total of four sister chromatids
chromatids
one of the two identical halves of a chromosome
synapsis
When homologous chromosomes pair up to form tetrads
crossing over
Swapping the segment
chiasmata
Site where homologous chromosomes are attached
Metaphase 1
Tetrads line up along equator
Anaphase 1
Only the tetrads split up, sister chromatids at each pole stay in place
dyads
a group of two
Telophase 1
the chromosomes are enclosed in nuclei.
Interkinesis 2
a period of rest that certain species’ cells experience between meiosis I and meiosis II
Prophase 2
Same as mitosis
Metaphase 2
Dyads line up
Anaphase 2
Dyads (sister chromatids) separate
Telophase 2
nuclear membrane forms
Independent Assortment
How the chromosomes align during metaphase 1 is completely random
Old Theory
explained variations
New Theory
explains problems w/ blending hypothesis
Alleles
alternate molecule forms of a gene
Recessive alleles
One that is masked
Dominant alleles
One that is exposed
Homozygous
RR (same letter)
Heterozygous
Rr (2 diff.)
Progeny
offspring
Complete Dominance
wherein the dominant allele completely masks the effect of the recessive allele
Phenotype
Physical appearance, purple, red
Genotype
Genetive makeup, RR Rr
Blending hypothesis
the theory that offspring have a blend, or mix, of the characteristics of their parents
Principle of Segregation
Pairs of genes separate during gamete formation fertilization pairs them once again
Monohybrid
1 trait
Monohybrid Cross
cross between two organisms with different variations
F1 gen
1 round of punnet square
F2 gen
2 rounds of punnet square
Incomplete Dominance
no dominant allele
Codominance
Has a dominant & recessive, more than 1 dominant, blood types
Epistasis
2 or more genes interact in such a way as to alter the expression of another gene
Pleiotropy
1 gene alters the expression of 2 or more traits (pigmentation)
Polygenic Inheritance
Inheritance of multiple genes that affect the same trait
Mendels Theory of Independent Assortment
the alleles of two (or more) different genes get sorted into gametes independently of one another
Linkage group
all the genes on 1 chromosomes
Autosomes
chromosomes that are same in male and female (41 or 22 pairs)
Sex chromosomes
chromosomes that are diff. in genders
Albinism
Autosomal recessive disorders
Cystic Fibrous
Autosomal recessive disorders
Sickle Cell Disease
Autosomal recessive disorders
Autosomal Recessive Disorders
2 recessive genes that need to combine with another to be exposed
Autosomal Dominant Disorders
pattern of inheritance characteristic of some genetic disorders
Alzheimers
Autosomal Dominant Disorders
Achondroplasia
Autosomal Dominant Disorders
Polydactyly
Autosomal Dominant Disorders
Sex-linked traits
Traits carried on the sex chromosomes
XX
Female
XY
Male
Mutations
Change in DNA Sequence
Breaks
damage occurring in the chromosome
Deletion
fragment breaks out/falls off
Cri du cat (cry of the cat)
a child is mentally retarted & cries like a cat, ex) of deletion
Duplication
Lost segment gets duplicated
Inverse
Lost segment attaches itself but becomes inverse
Translocation
lost segment attaches itself to a nonhomologous chromosome
CML (Chronic Myelogenous leukemia)
chr. # 22 switches w/ chr. #9 (reciprocal)
Somatic Chromosomes
any chromosome that is NOT a sex chromosome
Aneuploidy
chromosomal aberrations–chromosomes present in a xtra copies in #
Nondisjunction
Pair of chromosomes doesn’t separate during meiosis
Trisomy 13
Patau´s syndrome–death a few days after birth
Trisomy 18
Edward´s syndrome–death usually in a few months–affects almost every organ
Trisomy 21
Down Syndrome
YO
dies as a fetus
XO
turns into turners syndrome
Turner´s Syndrome
looks female but not
XXY
Klinefelter´s Syndrome
Klinefelter´s Syndrome
can appear normal but is sterile
XXX
Metafemale
Metafemale
looks female, no physical symptoms
XYY
no defined syndrome
Amniocentesis
a way to detect abnormalities
-found later in pregnancy
-takes longer
CVS (Chronic Villius sampling)
a way to detect abnormalities
-found earlier in pregnancy
-takes sooner
Barr body
has a wide degree of physical symptoms