Unit 2 B&B - Lecture Flashcards
Sperm + ovum = ?
zygote
3/1/24
What is the first major stage in development?
zygote
Multiple Choice
Which of the following are in the correct order, according to human development?
* zygote; blastocyst; morula; embryo
* morula; embryo; zygote; blastocyst
* zygote; morula; blastocyst; embryo
* blastocyst; zygote; morula; embryo
zygote; morula; blastocyst; embryo
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
When does a human have the most synapses?
* early embryonic development
* early childhood
* late in fetal development
* adolescence
early childhood
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
What is the name of the developmental period in which a human has the most quantity of neurons?
* adulthood
* at birth
* late in life
* adolescence
at birth
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Hormones are typically released ——– allowing them to exert effects throughout the body.
* into the synapse
* into the circulatory system
* into the brain
* outside the body
into the circulatory system
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Which component is necessary for apoptosis?
* Death genes
* Methylation
* Neurogenesis markers
* Neurotrophic factors
death genes
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Undifferentiated —— cells, if gathered from embryonic tissue and transplanted into the brain, will differentiate and integrate properly.
* mesodermal
* apoptotic
* stem
* ventricular
stem
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
——– regulates all hormone secretions and acts similar to a thermostat.
* negative feedback
* positive feedback
* action potentials
* endocrine gland shut down
negative feedback
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Which of the following statements is correct?
* pheromones definitely allow women to “sync up” menstrual cycles
* unlike most mammals, humans are not sensitive to hormones
* humans have a very sensitive vomeronasal organ
* there is mixed evidence regarding humans and pheromones
there is mixed evidence regarding humans and pheromones
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
—— is an example of a major class of steroid hormones produced by the ——
* testes; testosterone
* estrogen; gonads
* progestin; ovary
* progestin; gonads
ASK PROF - Got this wrong on quiz
answered “estrogen;gonads” but got it wrong
progestin - isn’t this synthetic progesterone? meaning it wouldn’t be produced in the ovary or gonads. This rules out C and D.
testes - testes are not hormones. This rules out A.
NEED TO ASK - Office Hours
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Which of the following hormones is MOST responsible for the masculinization of the zebra finch song system?
* testosterone
* estrogen
* progesterone
* androstenedione
estrogen
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Preventing estrogen synthesis in a male zebra finch during development would likely:
* lead to larger brain areas associated with song
* cause no significant changes in the song system of the brain
* create a gynandromorph bird
* lead to smaller brain areas associated with song
cause no significant changes in the song system of the brain
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Alzheimer’s disease causes a gradually loss of ———, due to the death of basal forebrain neurons.
* acetylcholine.
* dopamine.
* serotonin.
* norepinephrine.
acetylcholine
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
The process of apoptosis requires what?
* Methylation
* Neurogenesis markers
* Death genes
* Neurotrophic factors
death genes
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Reproduction that does NOT include the fusion of gametes or recombination of chromosomes is known as what?
* asexual reproduction
* infertile reproduction
* monecious reproduction
* ansiogametic reproduction
asexual reproduction
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
———- is a biological variable, including aspects of genes, hormones, gametes, and anatomy.
* sex
* gender
* sexuality
* masculinity and femininity
sex
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Which of the following accurately describes an epigenetic process?
* fertilization of an egg by a sperm
* cell differentiation in interneurons, due to exposure to sonic hedgehog proteins in the spinal cord
* preferring spicy food, because you were raised eating it
* in-vitro fertilization
cell differentiation in interneurons, due to exposure to sonic hedgehog proteins in the spinal cord
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
If Sheldon Cooper were to conduct an experiment on his roommate Leonard Hofstadter to enhance Leonard’s spatial memory, which of the following factors should Sheldon most likely manipulate?
- The number of glial cells in Leonard’s brain
- The size of Leonard’s neurons
- The rate of neurogenesis in Leonard’s adult brain
- The number of neurons Leonard had at birth
The rate of neurogenesis in Leonard’s adult brain
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Name the type of chemical communication.
oxytocin promotes the start of contractions in pregnant mammals
Hormone, allomone, pheromone, or synaptic?
hormone
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Name the type of chemical communication.
a cat releases a scent indicating it is in heat
Hormone, allomone, pheromone, or synaptic?
pheromone
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Name the type of chemical communication.
neurons in the frontal cortex release dopamine in response to eating chocolate cake
Hormone, allomone, pheromone, or synaptic?
synaptic
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Name the type of chemical communication.
trout emit a chemical to warn other trout of danger when spotting a predator
Hormone, allomone, pheromone, or synaptic?
pheromone
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Name the type of chemical communication.
a flower attracts a bee by emitting a sweet scent
Hormone, allomone, pheromone, or synaptic?
allomone
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Name the type of chemical communication.
the pituitary secretes FSH into the bloodstream, affecting the gonads
Hormone, allomone, pheromone, or synaptic?
hormone
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #1)
Multiple Choice
Nicotine and alcohol are examples of well known:
* types of polydactyly
* birth defectors
* teratogens
* endocrine disruptors
teratogens
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
Neurotrophins are an excitatory neurotransmitter.
* This statement is correct.
* Incorrect; neurotrophins are inhibitory neurotransmitters
* Incorrect; neurotrophins are both inhibitory and excitatory neurotransmitters
* Incorrect; neurotrophins are different from neurotransmitters
Incorrect; neurotrophins are different from neurotransmitters
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
These types of glands are hormone producing tissues.
* endocrine
* epigenetic
* neural
* gonadal
endocrine
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
Which would not be considered an extrinsic influence on cells?
* Induction
* Nutrition
* Genes
* Experience
genes
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
During development, an organism can be permanently changed by a teratogen if it occurs during the ———- period.
* plastic
* developmental
* flexible
* sensitive
sensitive
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
Which of the following statements is correct regarding humans?
* men produce testosterone; but not estrogen
* women produce testosterone and estrogen
* women produce estrogen, only when they are pregnant
* men do not produce testosterone or estrogen
women produce testosterone and estrogen
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
The development of ocular dominance as a results of increased connections between commonly used cells is an example of what?
* Hebbian synapses
* apoptosis
* synaptogenesis
* Watsonian connections
Hebbian synapses
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
Cell fate is determined by factors including chemical environment and genetic activity. This is also known as
* apoptosis
* epigenetics
* sexual differentiation
* methylation
epigenetics
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
Treating a female zebra finch egg with estrogen would most likely lead to which effect?
* the brain would fail to develop
* the brain would look more like the average male brain
* the brain would look hyper-feminine
* the brain would look no different
the brain would look more like the average male brain
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
In early development, the cells that create neurons undergo mitosis in the ———-.
* cerebral cortex
* spinal cord
* neural tube
* brain stem
neural tube
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
Why is it incorrect to say that sex is a binary characteristic in humans?
* there are more than 2 possible combinations of sex chromosomes
* none of these answers are correct
* because biology does not determine sex
* there are only 2 possible combinations of sex chromosomes
there are more than 2 possible combinations of sex chromosomes
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
From the analogy discussed in class, a gene is like a ——, while a chromosome is can be compared to a ———
- bookshelf with many cookbooks; single cookbook
- single recipe; bookshelf with many cookbooks
- single cookbook, single recipe
- single recipe; single cookbook
single recipe (gene); bookshelf with many cookbooks (chromosome)
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
A mutation in the SRY gene would likely disrupt what?
* gamete formation
* all of these answers are correct
* gonadal development
* sexual differntiation
all of these answers are correct
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
If Dr. Meredith Grey were to invent a device that could accelerate one stage of the nervous system development in a patient, which stage would most likely result in the patient developing new neural connections?
- Neurogenesis, the mitotic division of nonneuronal cells to produce neurons
- Cell migration, the massive movements of nerve cells or their precursors to establish distinct nerve cell populations
- Neuronal cell death, the selective death of many nerve cells
- Synaptogenesis, the establishment of synaptic connections as axons and dendrites grow
Synaptogenesis, the establishment of synaptic connections as axons and dendrites grow
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #3)
Multiple Choice
Which of the following is NOT a major division of the CNS visible in early development?
* spinal cord
* forebrain
* none of these answers is correct
* hindbrain
none of these answers is correct
On quiz, chose spinal cord but got it wrong
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
A drug that changes the amount of sonic hedgehog in the developing embryo would disrupt what?
* cell differentiation
* spinal cord development
* All of these answers are correct
* glial cell development
All of these answers are correct
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
Hormones are a critical part of which function?
* all of these answers are correct
* stress
* circadian rhythms
* hunger and digestion
all of these answers are correct
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
If a kitten’s left eye is occluded during the ——— visual cells later show ——– responses when visual stimuli is presented to the left eye
* sensitive; decreased
* critical; decreased
* sensitive; increased
* critical; increased
sensitive; decreased
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
Fragile X syndrome is characterized by a chromosome that is prone to breaking due to what?
* unstable DNA
* methylated genes
* reduced chromosomal count
* increased methylation
unstable DNA
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
Which of the following statements is correct regarding humans?
* men produce testosterone; but not estrogen
* women produce testosterone and estrogen
* men do not produce testosterone or estrogen
* women produce estrogen, only when they are pregnant
women produce testosterone and estrogen
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
Which of the following statements is correct?
* non-human animals are classified by gender, not sex
* biological sex is determined by societal expectation
* gender is determined by steroid hormones
* gender is unique to humans
gender is unique to humans
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
Which of the following conclusions are consistent with the findings on zebra finch, as discussed in class?
* only genetics drive sexual differentiation in the brain
* both hormones and genetics drive sexual differentiation in the brain
* neither hormones nor genetics drive sexual differentiation in the brain
* only hormones drive sexual differentiation in the brain
both hormones and genetics drive sexual differentiation in the brain
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
Preventing estrogen synthesis in a male zebra finch during development would likely:
* create a gynandromorph bird
* lead to larger brain areas associated with song
* cause no significant changes in the song system of the brain
* lead to smaller brain areas associated with song
cause no significant changes in the song system of the brain
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
At present, the only way to identify Alzheimer’s disease with confidence is through
* postmortem examination.
* genetic screening.
* olfactory testing.
* MRI.
postmortem examination
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
PGT can NOT be used to assess what?
- chromosomal abnormalities
- all of these answers are correct
- gender
- chromosomal sex
gender
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
Multiple Choice
If Dr. Bruce Banner (a.k.a., the Hulk) were to mutate due to an experiment gone wrong, causing his nervous system to develop abnormally, which of the following stages would most likely be affected?
- The formation of the three distinct cell layers in the embryo
- The development of the neural tube from the neural groove
- The transition from the embryo to the fetus stage
- The division of the single cell after fertilization
The development of the neural tube from the neural groove
Nervous System Development Quiz (Unit 2 - Quiz 1 - Attempt #2)
According to class, the ultimate function of the brain is [blank1].
homeostasis
In Class Homeostasis Learning Check
Eating a bunch of very salty chips would mostly likely result in ——–.
osmotic thirst
In Class Homeostasis Learning Check
Why is it a good idea to rehydrate with a slightly salty solution after a period of heavy sweating?
sweating causes the loss of bodily fluids AND electrolytes like sodium
In Class Homeostasis Learning Check
Humans are an ——- species
endothermic
In Class Homeostasis Learning Check
Most homeostatic systems work on a ——–feedback system.
negative
In Class Homeostasis Learning Check
Name the stages
Zygote > ————– > ————— > —————- > —————
(prenatal)
zygote > morula > blastocyte > embryo > fetus
Lecture 3/1/2024: Development of the Nervous System
The ———– embeds to the uterus.
blastocyte
Lecture 3/1/2024: Development of the Nervous System
Two weeks post-conception, the “baby” is called an ————.
embryo
Lecture 3/1/2024: Development of the Nervous System
The “baby” is not called a fetus until —————– post-conception.
eight weeks
Lecture 3/1/2024: Development of the Nervous System
What are the 3 layers of cells in a developing human embryo?
Ectoderm, mesoderm, endoderm
Lecture 3/1/2024: Development of the Nervous System
The ectoderm cells will eventually make up ——— and ———– tissue.
skin, neural tissue
Lecture 3/1/2024: Development of the Nervous System
Cells in the —————– will become the skeleton and cardiac system.
layer of cells in embryo development
mesoderm
Lecture 3/1/2024: Development of the Nervous System
Cells in the ————— will become the digestion and respiratory systems.
layer of cells in embryo development
endoderm
Lecture 3/1/2024: Development of the Nervous System
Dorsal surface tissue will become the ————— system.
nervous
Lecture 3/1/2024: Development of the Nervous System
————– of the ————— leads to development of the neural plate.
thickening; ectoderm
Lecture 3/1/2024: Development of the Nervous System
The first step of neural development we’ve studied in class is the —————- of the ———————-, which is explains the beginning of cells organizing themselves into the nervous system.
induction; neural plate
Lecture 3/1/2024: Development of the Nervous System
Everything happening during development is induced by ————————-.
chemical signaling
Lecture 3/1/2024: Development of the Nervous System
The thickening of the ectoderm leads to the development of the neural plate. The neural plate then starts to form the ——————-, which then closes to form the ——————.
neural groove; neural tube
neural crest is the “peak” of the neural groove
Lecture 3/1/2024: Development of the Nervous System
The neural tube is where we find the ——————–. The anterior portion of the neural tube will become the ———-.
spinal cord; brain
Lecture 3/1/2024: Development of the Nervous System
The neural tube forms about ———– days post-conception.
22
Lecture 3/1/2024: Development of the Nervous System
A(n) ——————- called —————- occurs if the neural tube fails to close correctly.
neural tube defect; spina bifida
Lecture 3/1/2024: Development of the Nervous System
When something goes wrong during development of the neural tube, it results in a(n) ————————–.
Neural tube defect
Lecture 3/1/2024: Development of the Nervous System
Neural tube defects can be caused by low —————- and/or exposure to ——————–.
maternal folic acid; teratogens
Lecture 3/1/2024: Development of the Nervous System
Chemicals that can impact or disrupt development are ————.
teratogens
examples are alcohol and nicotine
Lecture 3/1/2024: Development of the Nervous System
Why is extra folic acid included in so many products?
Because low maternal folic acid is associated with an increased risk of neural tube defects
Lecture 3/1/2024: Development of the Nervous System
The most common neural tube defect is ———–.
spina bifida
Lecture 3/1/2024: Development of the Nervous System
————– occurs when the neural tube does not close at the top, preventing proper development of the skull. It generally results in more severe outcomes than other neural tube defects.
anencephaly
Lecture 3/1/2024: Development of the Nervous System
When the neural tube fails to close properly along the spinal cord area, it results in ——————-. It can have effects varying in severity.
spina bifida
Lecture 3/1/2024: Development of the Nervous System
True/False:
Spina bifida is usually correctible with surgery after birth.
True
Lecture 3/1/2024: Development of the Nervous System
Why is it hard to pinpoint what causes a birth defect?
birth defects due to teratogen exposure can occur at any stage during development; many issues can cause the same impacts AND one issue can cause many impacts
Lecture 3/1/2024: Development of the Nervous System
a disruption to the cardiac system during development
congenital heart defect
congenital = happening during prenatal development
Lecture 3/1/2024: Development of the Nervous System
A type of birth defect that is caused by the neural tube closing improperly
Neural tube defect
Lecture 3/1/2024: Development of the Nervous System
When facial muscle bones are forming, they may not fully come together. This is known as ————.
Orofacial clefts
Lecture 3/1/2024: Development of the Nervous System
A birth defect that causes development of additional fingers and toes.
polydactyly
Lecture 3/1/2024: Development of the Nervous System
Name three categories of teratogens.
Chemicals; infections; environments (internal and external)
Lecture 3/1/2024: Development of the Nervous System
Earlier teratogen exposure usually leads to ——————– deficits.
more severe
Lecture 3/1/2024: Development of the Nervous System
List the six phases of brain (or nervous system) development.
- neurogenesis
- cell migration
- cell differentiation
- synaptogenesis
- cell death (apoptosis)
- synapse rearrangement
Lecture 3/1/2024: Development of the Nervous System
Name the phase of nervous system development.
the birth of new neural cells
neurogenesis
Lecture 3/1/2024: Development of the Nervous System
Name the phase of nervous system development.
cells leave ventricular zone and head to different areas in the body where they will start developing the nervous system
cell migration
Lecture 3/1/2024: Development of the Nervous System
Name the phase of nervous system development.
this stage is dependent on cell’s location or timing
cell differentiation
Lecture 3/1/2024: Development of the Nervous System
Name the phase of nervous system development.
after cells are created, they create connections between one another to pass messages through the nervous system
synaptogenesis (creation of synapses)
Lecture 3/1/2024: Development of the Nervous System
Name the phase of nervous system development.
excess neurons unable to get necessary chemical for survival start to die off
cell death (or apoptosis)
Lecture 3/1/2024: Development of the Nervous System
Name the phase of nervous system development.
weaker synaptic connections are eliminated while stronger connections are kept and strengthened
synapse rearrangement
Lecture 3/1/2024: Development of the Nervous System
———- is a period of intense cell proliferation.
neurogenesis
Lecture 3/1/2024: Development of the Nervous System
What is cell proliferation and during which stage in neural development does it occur most?
generation of new cells; neurogenesis
Lecture 3/1/2024: Development of the Nervous System
Where does neurogenesis occur?
in the ventricular zone of the neural tube
region of neural tube responsible for massive amounts of proliferation
Lecture 3/1/2024: Development of the Nervous System
the rate of cell proliferation within the ventricular zone of the neural tube can be about ——————– per min.
250,000
Lecture 3/1/2024: Development of the Nervous System
Neurogenesis leads to the creation of cells that are not specialized yet, called:
undifferentiated cells
Lecture 3/1/2024: Development of the Nervous System
at the start of cell migration, the cells are ————-.
undifferentiated
differentiation occurs as cells migrate
Lecture 3/1/2024: Development of the Nervous System
During the migration phase, cells are only a(n) ————– and a(n).
soma; immature axon
Lecture 3/1/2024: Development of the Nervous System
How do undifferentiated cells become differentiated?
through chemical signaling interactions, specifically location or timing
Lecture 3/1/2024: Development of the Nervous System
The ectodermal tissue acquires its neural fate through chemical signaling. Another series of signaling interactions determine the type of neural cell, ——— or ———–.
neurons (including motor neurons and interneurons) and glia
Lecture 3/1/2024: Development of the Nervous System
Cells can be exposed to differentiation either through ———- or ———-.
timing; location
Lecture 3/1/2024: Development of the Nervous System
The signaling protein —————-, is an example of cell differentiation through location.
Sonic Hedgehog
Lecture 3/1/2024: Development of the Nervous System
The signaling protein, Sonic Hedgehog (Shh), is important for ——————- development.
spinal cord
Lecture 3/1/2024: Development of the Nervous System
A cell that encounters high Shh will become ———-; medium Shh will become ———-; low Shh will become ————.
glia; motor neuron; interneuron
Lecture 3/1/2024: Development of the Nervous System
In the cerebral cortex, neurons migrate from the ventricular zone on ——————- to become ———————–.
radial glia; gray matter
Lecture 3/1/2024: Development of the Nervous System
Radial glia act as ———- for neurons in the development of the cerebral cortex.
scaffolding
old cells form lower levels, new cells climb past them to higher levels
Lecture 3/1/2024: Development of the Nervous System
Why is the cerebral cortex organized into such well-defined layers?
because neurons use radial glia as scaffolding, so newer neurons climb past layers of older neurons to higher levels.
Lecture 3/1/2024: Development of the Nervous System
The final position of the layers of cerebral cortex is correlated exactly to —————–.
the birthdate
this is helpful because if we see defects in formation of cortex, we can look at the time in development that these cells were formed and identify what may have happened at that point in development.
Lecture 3/1/2024: Development of the Nervous System
in the cerebral cortex, cells that are leaving later migrate past the older neurons, creating ————— layering.
inside-out
Lecture 3/1/2024: Development of the Nervous System
phase of nervous system development when synapses are created
synaptogenesis
Lecture 3/1/2024: Development of the Nervous System
After synapses are formed, how does communication happen between the two cells?
chemical signaling
Lecture 3/1/2024: Development of the Nervous System
during synaptogenesis, synapses are vital for cell-to-cell communication as well as —————-
cell survival
Lecture 3/1/2024: Development of the Nervous System
the —————– of unfinished axons are searching the extracellular environment for connections to ————- of other cells. The neighboring cells attract the cells’ axon by ———————.
The ——— transforms into ———, which connects to the ————— of the postsynaptic cell, forming a(n) ———–.
During which phase of nervous system development does this occur?
growth cones; dendritic spines; emitting chemical signals
growth cone transforms into the axon terminal; dendritic spines; synapse
synaptogenesis
Lecture 3/1/2024: Development of the Nervous System
——————— discovered that connections between cells do not determine how many axons form, they determine —————————–. This process is determined by ——————–.
1 is a person, 2 is a verb, and 3 is a thing.
Rita Levi-Montalcini; how many survive; neurotrophins
Lecture 3/1/2024: Development of the Nervous System
The neurotrophin discovered by Levi-Montalcini.
Nerve Growth Factor
Lecture 3/1/2024: Development of the Nervous System
What does nerve growth factor (NGF) do?
NGF is a neurotrophin protein released by cells necessary for axon survival. It plays a role in the stage of nervous system development where neurons are overproduced and die if they don’t make a connection. Only cells that get NGF will make connections with other cells and survive.
Lecture 3/1/2024: Development of the Nervous System
Does a healthy adult nervous system contain more neurons?
No, we have all of the cells needed at birth
Lecture 3/1/2024: Development of the Nervous System
Between —-% and —-% of neurons created will die after migration.
50; 75
Lecture 3/1/2024: Development of the Nervous System
What is another word for cell death?
apoptosis
Lecture 3/1/2024: Development of the Nervous System
T/F
Cell death (apoptosis) is unnecessary and harmful, and ideally, it would not occur during development.
False; cell death is normal and necessary otherwise we would have many cells that take up energy but don’t provide any function for us
Lecture 3/1/2024: Development of the Nervous System
In case something goes wrong, we ———— cells during development.
overproduce
Lecture 3/1/2024: Development of the Nervous System
Only cells that successfully compete for chemicals make functional connections and survive. What is this called?
Neural Darwinism
Lecture 3/1/2024: Development of the Nervous System
T/F:
A healthy adult CNS has many neurons without appropriate connections.
False; a healthy adult CNS has very few neurons without appropriate connections
Lecture 3/1/2024: Development of the Nervous System
Neurotrophins are very important during development and also throughout the lifespan. What are three things that neurotrophins do?
- promote cell growth and survival
- guide axons
- stimulate synaptogenesis
Lecture 3/1/2024: Development of the Nervous System
—————- are a family of proteins essential for development of the vertebrate nervous system and help with cell survival during development.
Neurotrophins
Lecture 3/1/2024: Development of the Nervous System
Name 4 neurotrophins.
- nerve growth factor (NGF)
- brain-derived neurotrophic factor (BNDF)
- neurotrophin 3 (NT3)
- neurotrophin 4-5 (NT4/5)
Lecture 3/1/2024: Development of the Nervous System
———— are expressed only when a cell undergoes apoptosis (in the absence of ————)
death genes; neurotrophins
Lecture 3/1/2024: Development of the Nervous System
Explain the process of cell death (apoptosis).
A cell does not receive neurotrophins and is unable to create strong enough synaptic connections with other cells. Death genes are expressed. The cell shrinks and loses any physical connections with neighboring cells then blebs, and the nucleus collapses. Finally, the cell breaks down into apoptopic bodies and remaining debris is broken down by white blood cells.
Lecture 3/1/2024: Development of the Nervous System
The process of synapse rearrangement is —————————-, meaning cells that are not used die off.
experience-dependent
Lecture 3/1/2024: Development of the Nervous System
Synapse rearrangement allows for ————- and ———–.
neural adaptation and recovery
Lecture 3/1/2024: Development of the Nervous System
The process of losing weaker connections between cells is known as —————.
Pruning
Lecture 3/1/2024: Development of the Nervous System
Within 3 years, a human goes from about ———— synapses per cell to ———— synapses per cell.
2500 to 15000
Lecture 3/1/2024: Development of the Nervous System
Adults have approximately ——— synapses per cell.
7000
Lecture 3/1/2024: Development of the Nervous System
What is the ultimate function of the brain?
homeostasis
LECTURE 3/18/2024: HOMEOSTASIS
What is homestasis?
any biological processes that keep body variables within a fixed range
LECTURE 3/18/2024: HOMEOSTASIS
List some homeostatic mechanisms.
body temp, levels of water, oxygen, glucose, calcium, protein or fat, etc.
sun, air supply, survival without water or food
LECTURE 3/18/2024: HOMEOSTASIS
Homeostasis is controlled by ——– and ——- systems.
physiological; behavioral
Homeostasis includes any biological processes that keep body variables within a ———–.
fixed range
Who holds the record for longest amount of time without water? How did this happen and what was his record?
Andreas Mihavecz was forgotten about in a jail cell for 18 days. He did not have water, but was able to lick condensation off of the wall.
LECTURE 3/18/2024: HOMEOSTASIS
Who holds the record for longest amount of time without food? How did this happen and what was the record?
Angus Barbieri lived for 382 days without food. He was under dr. supervision and received some nutrients throughout but no significant calories. He went from 456 lbs to 180lbs and died in 1990. The food deprivation period did not seem to impact his lifespan.
LECTURE 3/18/2024: HOMEOSTASIS
What is the average amount of time a person can go without water?
about a week
LECTURE 3/18/2024: HOMEOSTASIS
What is the average amount of time a person can go without food?
estimated to be between 21 and 40 days, but there is a debate about how long a person can go without food
LECTURE 3/18/2024: HOMEOSTASIS
What are three ways in which a person can die by anorexia?
- myocardial infarction
- organ failure
- refeeding and sodium toxicity (if refeeding is not supervised, this can be dangerous because the body is pulling salt from different places and NA/K pumps are not working correctly)
LECTURE 3/18/2024: HOMEOSTASIS
If a person with anorexia undergoes refeeding unsupervised, they are at risk of ——————-.
sodium toxicity
LECTURE 3/18/2024: HOMEOSTASIS
Humans can go without air for about ——————.
3 minutes
LECTURE 3/18/2024: HOMEOSTASIS
What is static apnea?
a person has trained themselves to go without oxygen for an extended period of time
LECTURE 3/18/2024: HOMEOSTASIS
The record for air deprivation (for someone who has undergone static apnea training) is ————–.
24 minutes and 3 seconds
LECTURE 3/18/2024: HOMEOSTASIS
When a person hypersaturates their lungs with pure oxygen then holds their breath for an extended period of time, it is known as ——————-.
oxygen assist
LECTURE 3/18/2024: HOMEOSTASIS
How did a Russian cult contribute to our understanding of sunlight deprivation?
The cult lived in tunnels underground, so children had never been exposed to sunlight. They developed vitamin D deficiencies (rickets) and serotonin deficiencies.
LECTURE 3/18/2024: HOMEOSTASIS
When a person’s bones soften due to proloned and extensive vitamin D deficiency, it is called ——–.
Rickets
LECTURE 3/18/2024: HOMEOSTASIS
Who holds the record for longest amount of time without sleep? What was the record?
A high schooler named Randy Gardner stayed awake for 11 days (264 hrs).
LECTURE 3/18/2024: HOMEOSTASIS
After being deprived of sleep for —— to —— days, a person will typically have several cognitive and physiological impairments.
2-3 days
LECTURE 3/18/2024: HOMEOSTASIS
——- is the maintenance of a stable, balanced, internal environment
homeostasis
LECTURE 3/18/2024: HOMEOSTASIS
homeostasis is controlled by ——- and ——- systems.
physiological; behavioral
LECTURE 3/18/2024: HOMEOSTASIS
Changes in our internal environment can affect ———–, a psychological process that induces or sustains certain behavior.
Motivation
LECTURE 3/18/2024: HOMEOSTASIS
The longer we go without eating, the longer our internal environment undergoes physiological changes = the more ———– we will be to partake in certain behaviors.
motivated
LECTURE 3/18/2024: HOMEOSTASIS
—————– > change in motivation > —————–
physiological event > change in motivation > change in behavior
LECTURE 3/18/2024: HOMEOSTASIS
———- generate their own heat through internal processes.
Endotherms
LECTURE 3/18/2024: HOMEOSTASIS
———- get most of their heat from the environment
Ectotherms
LECTURE 3/18/2024: HOMEOSTASIS
Ectothermic organisms lack the internal physiological mechanisms for ———————.
temperature regulation (they rely on the environment for regulating temperature)
LECTURE 3/18/2024: HOMEOSTASIS
Amphibians, reptiles, and most fish are ————.
Ectotherms
LECTURE 3/18/2024: HOMEOSTASIS
It is a misnomer to refer to ectotherms as —————-. Why?
cold-blooded; because ectotherms will die if their body temperature drops below freezing
LECTURE 3/18/2024: HOMEOSTASIS
What happens if an ectotherm’s body temperature drops below freezing?
ice crystals will form in their cells and blood, causing blood vessels to rupture and the animal to bleed to death
LECTURE 3/18/2024: HOMEOSTASIS
Some insects and fish have evolved mechanisms that have ——– component in circulatory system, allowing them to essentially freeze solid without decaying.
antifreeze
LECTURE 3/18/2024: HOMEOSTASIS
Ectotherm’s body temperature matches ————–.
their external environment
LECTURE 3/18/2024: HOMEOSTASIS
insects and fish with “antifreeze” component have extraordinary ———- ability
blood-clotting
can quickly repair ruptured blood vessels
LECTURE 3/18/2024: HOMEOSTASIS
Endoterms have internal physiological mecahnisms that ———————-.
help maintain almost constant body temperature (small temperature range)
LECTURE 3/18/2024: HOMEOSTASIS
Most mammals and birds are ——–.
endothermic
LECTURE 3/18/2024: HOMEOSTASIS
What is a disadvantage of being endothermic?
it requires a lot of energy and fuel
LECTURE 3/18/2024: HOMEOSTASIS
We can decrease our body temperatures through physiological responses like ——— or ———.
sweating; panting
LECTURE 3/18/2024: HOMEOSTASIS
We can increase our body temperatures through physiological responses such as ———, ———, ———-, etc.
shivering; decreasing blood flow to skin; fluffing out fur to increase insulation
LECTURE 3/18/2024: HOMEOSTASIS
What is the advantage of being endothermic?
Muscle activity benefits from being as warm as possible; Ready for vigorous activity much more quickly than endotherms
LECTURE 3/18/2024: HOMEOSTASIS
Homeostatic mechanisms are primarily —————— systems.
negative feedback
LECTURE 3/18/2024: HOMEOSTASIS
What is the set point?
The optimal value that we want our homeostatic systems at (e.g., set point for temperature in humans is 98.6)
LECTURE 3/18/2024: HOMEOSTASIS
A deviation from the set point results in ——————–.
a compensatory action (ex. if we get too cold, we’ll shiver)
LECTURE 3/18/2024: HOMEOSTASIS
A ———– is a range of tolerance in a system.
set zone (ex. think of a thermostat)
LECTURE 3/18/2024: HOMEOSTASIS
On a line graph, a negative feedback system would be represented by a ——— line.
wavy
the value will reach its peak then the body will take action to lower it; the value will reach its low point, then the body will take action to raise it
(ex. thermostat)
LECTURE 3/18/2024: HOMEOSTASIS
In a negative feedback system, there will be ———- above and below the ——— temperature.
variability; average
LECTURE 3/18/2024: HOMEOSTASIS
Physiological systems show ————–.
redundancy
they are monitored by more than 1 mechanism
LECTURE 3/18/2024: HOMEOSTASIS
What are the two thermoregulatory systems in rats?
- autonomic: reduces body heat produced and increases blood flow to tail (bc it is not covered in fur and dispenses a lot of heat)
- behavioral: animals will seek out colder environment
- Preoptic area (POA)
- Warm sensitive neurons
LECTURE 3/18/2024: HOMEOSTASIS
In rats, lesions to ——– impair physiological responses to cold. This only impacts ————— regulation; not ———— response.
POA; autonomic; behavioral
LECTURE 3/18/2024: HOMEOSTASIS
What are the three strategies used to regulate behavior in a thermoregulatory system?
- change exposure of body surface (tuck in tail)
- change external insulation (ex. wear coat)
- change surroundings (go to warmer area)
LECTURE 3/18/2024: HOMEOSTASIS
In rats, lesions to the POA do not impact ————- responses to cold.
behavioral
LECTURE 3/18/2024: HOMEOSTASIS
Lesioning the ———- in rats impacts autonomic regulation of temperature, whereas lesioning the ————— impacts behavioral regulation of temperature
POA; lateral hypothalamus
LECTURE 3/18/2024: HOMEOSTASIS
Research into the POA and lateral hypothalamus’s roles in rat’s thermoregulation suggests what?
rats regulate their body temperature in at least two ways, and each is moderated by a different part of the brain
LECTURE 3/18/2024: HOMEOSTASIS
The ————- is involved in reward, feeding, sleep, stress.
lateral hypothalamus
LECTURE 3/18/2024: HOMEOSTASIS
In rats, lesions to the ——————– cause the rats to stop behavioral regulation of temperature. They do not involve ———— responses.
lateral hypothalamus; physiological
LECTURE 3/18/2024: HOMEOSTASIS
——— heavily rely on behavioral thermoregulation responses.
Ectotherms
LECTURE 3/18/2024: HOMEOSTASIS
What are two thermoregulation behaviors of ectotherms?
- moving toward or away from a heat source
- allowing their temperature to rise to fight infection (endotherms use internal processes to generate a fever)
LECTURE 3/18/2024: HOMEOSTASIS
Endotherms use ————– processes to generate a fever to fight infection.
internal
LECTURE 3/18/2024: HOMEOSTASIS
Where are thermoreceptors found?
throughout the body in the skin; body core; and hypothalamus
LECTURE 3/18/2024: HOMEOSTASIS
What are TRP receptors?
temperature-sensitive receptors
LECTURE 3/18/2024: HOMEOSTASIS
We use ————— to monitor our thermoregulatory system.
thermoreceptors/TRP receptors
LECTURE 3/18/2024: HOMEOSTASIS
Which receptors respond to capascin and menthol?
TRPV1
LECTURE 3/18/2024: HOMEOSTASIS
What are TRP receptors responsible for?
detecting temperature and transmitting info
LECTURE 3/18/2024: HOMEOSTASIS
TRP receptor pathway
spinal cord > brainstem > hypothalamus
LECTURE 3/18/2024: HOMEOSTASIS
What happens when body temperature goes outside of set zone?
neural regions initiate physiological and behavioral responses to try to return temperature to the set zone (sweat, shiver, find different environment)
LECTURE 3/18/2024: HOMEOSTASIS
True/False:
Our thermoregulatory system only monitors our external environment.
False; also regulates internal temp
LECTURE 3/18/2024: HOMEOSTASIS
What is the set zone for human body temperature?
about 95 to 107 degrees F
LECTURE 3/18/2024: HOMEOSTASIS
When internal core reaches ——- degrees Farenheit, initial symptoms of hypothermia set in, including shivering, dizziness, confusion, increased heart rate.
95
LECTURE 3/18/2024: HOMEOSTASIS
The average “normal” body temperature for a human is ———–.
98.5
LECTURE 3/18/2024: HOMEOSTASIS
Our temperature varies ————.
throughout the day (lower in the AM and varies during sleep, activity)
LECTURE 3/18/2024: HOMEOSTASIS
Women tend to have slightly ——– baseline temp than men
higher (by about .5)
LECTURE 3/18/2024: HOMEOSTASIS
generally normal optimal temperature range
97-99 degrees
LECTURE 3/18/2024: HOMEOSTASIS
——— typically indicates an average fever resulting from illness or infection
101.5 degrees
LECTURE 3/18/2024: HOMEOSTASIS
——– degrees is classifed as a serious fever.
103
LECTURE 3/18/2024: HOMEOSTASIS
At ——— degrees, people can experience multiple organ failure and seizures.
107
LECTURE 3/18/2024: HOMEOSTASIS
What are some homeostatic systems?
Temperature, hunger, thirst
LECTURE 3/20/2024: THIRST
What is an endotherm and how does it differ from an ectotherm?
WRONG FLASHCARD A set point is the “ideal” point (98.6degrees)
A set zone – range that the system needs to stay in for survival
What is a set point and how dies it differ from a set zone?
WRONG FLASHCARD Body temp comes from organism vs. body temp comes from external environment
What are TRP receptors?
Thermoreceptors – receptors important for monitoring internal and external temperature; also play a role in pain, touch, gustatory/taste system
Excessive water loss is ——-.
dehydration
Fluid retention is essential because we need it in the —————— and ——————-.
intracellular compartment; extracellular compartment
The extracellular compartment is divided between:
- interstitial fluid (extracellular fluid)
- blood plasma (in cardiac system, carries hormones, etc.
When we move outside of the set zone for thirst, we become ——-.
dehydration
why do we need water?
water moves through major components in the body and is needed for biological function; needed in both intracellular compartment and extracellular compartment
We want a ————– in fluid and ions across both sides of cellular membrane.
balance
Body attempts to balance ———- and ——— of fluid across both sides of the membrane.
volume (equalization pressure); concentration (chemical diffusion pressure)
Thirst is triggered due to internal changes in fluid ———— or ————–.
volume (amount of fluid in body); concentration (ratio of fluid to sodium)