Ulcerative Colitis Flashcards
1
Q
AETIOLOGY
Risk factors
A
- FH
- HLA-B27 gene
- Infection
2
Q
What gene is linked to UC
A
HLA-B27
3
Q
CLINICAL FEATURES
Presentation
A
- Rectal bleeding
- Blood in stool
- Diarrhoea
- Abdominal pain
- Malnutrition
- Abdominal tenderness
4
Q
Is rectal bleed/blood in stool more indicative of crohns or UC
A
Ulcerative colitis
5
Q
MANAGEMENT
General principles
A
- Induce remission
- Maintain remission
- Surgery is an option
6
Q
MANAGEMENT
Drugs for inducing remission lines
A
- Mild to moderate
- 1) Aminosalicylate (eg mesalazine oral or rectal)
- 2) Corticosteroids (prednisolone)
- Severe
- 1) IV corticosteroid (eg hydrocortisone)
- 2) IV ciclosporin
7
Q
MANAGEMENT
Drugs for maintaining remission
A
- Aminosalicylate (eg mesalazine oral or rectal)
- Azathioprine
- Mercaptopurine
8
Q
MANAGEMENT
Surgical options
A
- Panproctolectomy (removal of colon and rectum)
- Requires permanent iliostomy or ileo0anal anastomosis (J pouch)
9
Q
COMPLICATIONS
A
- Inflammatory pseudopolyps
- Colonic adenocarcinoma
- Primary sclerosing cholangitis
- Benign stricture
