Crohn's Flashcards
1
Q
AETIOLOGY
Risk factors
A
- White
- Age 15-40 or 60-80
- FH
- Smoking (contrast to UC)
2
Q
CLINICAL FEATURES
Key diagnostic factors
A
- Abdoominal pain
- Prolonged diarrhoea
- Blood in stool
- Perianal lesions
- Bowel obstruction
- Fever
- Fatigue
3
Q
MANAGEMENT
General principles
A
- Steroids to induce remission, if they dont work add another immunosuppressant medication
- Remission maintained by drugs tailored to patient
- Surgery possible if drug only affects distal ileum, can also be used to treat strictures and fistulas
4
Q
MANAGEMENT
First line steroids
A
Oral prednisolone or IV hydrocortisone
5
Q
MANAGEMENT
What immunosuppresants can be added to steroids to induce remission
A
- Azathioprine
- Mercaptopurine
- Methotrexate
- Infliximab
- Adalimumab
6
Q
MANAGEMENT
First line drugs to maintain remission
A
- Azathioprine
- Mercaptopurine
7
Q
MANAGEMENT
2nd line alternatives to maintain remission
A
- Methotrexate
- Infliximab
- Adalimumab
8
Q
COMPLICATIONS
A
- Intestinal obstruction
- Complications related to malabsorption
- Anaemia
