UCSF Pathology/Microbiology Flashcards
What type of virus is Hepatitis B?
DNA virus
Incubation time for Hepatitis B?
1-6 months
Describe symptoms of Hepatitis B
Jaundice
Fatigue
Flu-like symptoms
*30% of people have No symptoms with infection
What is commonly seen in patients with HBV?
No symptoms
What is the first detectable evidence of HBV?
HBsAg (Hep B Surface Antigen)
When does HBsAg appear?
appears within 3-4 weeks of exposure and 1-2 months prior to clinical disease
What does the presence of HBc IgM indicate?
Indicates acute infection
It takes time to develop the anti-HBs but anti HBc IgM develops initially.
What does the presence of HBeAg indicate?
May indicate viral replication. Presence associated with increased infectivity in association with HBsAg
What would the presence of Anti-HBe indicate?
This is a favorable sign in carriers, suggest that a low degree of infectivity is present
What would the presence of Anti-HBs indicate?
Indicates past infection and provided immunity. This appears after HBsAg disappears
What antibody is first to fight an acute infection?
IgM - also an indicator of current infection
What does IgG indicate?
Indicator of past or recent infection. Represents 75% of circulating antibodies
Define Paget’s Disease?
An uncommon fibro-osseous condition of unknown cause that produces ENLARGEMENT of the skull and jaws.
What are the 2 most common features or clinical signs of Paget’s Disease
- Distinctive radiographic appearance of Cotton Wool
- Increased alkaline phosphatase
Describe the prognosis of Paget’s Disease
Continual enlargement and weakening of bones
- Potential of undergoing malignant transformation
Describe clinical features of Cherubism
Cherub appearance due to bulging of the mandible
- multilocular cysts of both jaws
- giant cell tumors are wide spread
- premature tooth loss
A patient presents with symmetric bilateral enlargement in posterior areas of the mandible.
- Radiographs reveal large, multilocular radiolucencies
Most likely Cherubism (familial fibrous dysplasia)
How is Cherubism inherited?
Autosomal dominant
What is Eagle’s Syndrome
Elongation of the Styloid process and stylohyoid ligament calcification
Symptoms of Eagle’s syndrome
The tissues in the throat rub on the elongated styloid process during the act of swallowing. This results in pain along the glossopharyngeal nerve
- Also pain when turning head or extending the tongue
What is Osteopetrosis?
Inhibition of Bone Resorption
- Due to lack of osteoclasts activity. They are present but with no function
Describe the difference between Osteopetrosis seen in infants vs that seen in adults
Infantile: Autosomal recessive. Very severe with common fractures
Adult: Autosomal dominant. Milder form that starts off asymptomatic but progresses
What is the average age that an Odontogenic Keratocyst (OKC) is found?
20
WHere is the most common location of an OKC?
Mandibular ramus or third molar region
Describe radiographic appearance of an OKC
Unilocular or multilocular and well demarcated. It mostly displaces roots but can cause root resorption
What is an Ameloblastoma?
Uncommon benign jaw neoplasm of odontogenic epithelium.
What is the radiographic appearance of an Ameloblastoma?
Multilocular radiolucency.
- **Soap Bubble appearance
Expansive and destructive
Where are ameloblastomas commonly found?
Mandibular ramus
Often associated with boney impacted wisdom teeth
Where are Calcifying Epithelial Odontogenic Tumors commonly found?
Mandibular molar area
Describe characteristics of a Calcifying Epithelial Odontogenic Tumor?
Swelling, flecks of calcification, expansive
-**Driven snow appearance