U8.1.2 DRUGS OF ABUSE Flashcards
Hallucinogens
Substances that cause hallucinations
LSD, PCP, Ketamine, Scopolamine
Hallucinogens
- Lysergic acid diethylamide Claviceps purpurea
- synthetic agent related to ergot alkaloids
LSD
Hallucinogens
- NE, dopamine, serotonin
- 5-HT1a & 5-HT1c agonists
LSD
Hallucinogens
- one of the most potent drugs 1ug/kg
- absence of known fatalities
LSD
Hallucinogens
- duration based on dose
- waxing and waning e ffects
LSD
Hallucinogens
Symptoms :
rise in body temp, Hallucinations, uterine contractions, elevated sugar levels, Goosebumps, Euphoria, pupil dilation
LSD
Hallucinogens
- Lophophora williamsii
- Restricted but allowed occasionally to North
American Indians
Mescaline
Hallucinogens
Psilocybe mushroom
Psilocybin
Hallucinogens
Symptoms :
Mydriasis, muscle relaxation, dizziness
Psilocybin
Hallucinogens
Anesthetic, “special K” “vitamin K”
Ketamine
Hallucinogens
Symptoms : dream-like states, hallucination, delirium, amnesia,
high BP, depression, fatal respiratory problems
Ketamine
Hallucinogens
- phenylcyclohexamine derivative
- veterinary anesthetic
Phencyclidine
Hallucinogens
angel dust, PCP
Phencyclidine
Hallucinogens
- smoked with tobacco, snorted, Oral, IV
- antagonize NMDA
Phencyclidine
Hallucinogens
- long t1/2
- users tend to be violent and suicidal
- bad-trips
Phencyclidine
Hallucinogens
Hyoscyamus niger
Scopolamine
Hallucinogens
- block central muscarinic receptors
- unpleasant to users
Scopolamine
Hallucinogens
Erythroxylon coca
Cocaine
Hallucinogens
- dopaminergic reuptake transmitter
- inhibit reuptake of dopamine and NE
Cocaine
Hallucinogens
- free base is absorbed as fast as IV
- t1/2= 1hr, repeated 30min
Cocaine
Hallucinogens
Symptoms :
- feeling of bugs under skin
- paranoia and schizophrenia like state
- exhaustion by lack of sleep and food
- appetite, exhaustion, depression
Cocaine