TZD Flashcards
1
Q
Thiazolidinediones examples
A
(TZDs)
“glitazones”
2
Q
TZD MOA
A
PPARγ agonist (nuclear receptor) –> gene transcription to inc insulin sensitivity
3
Q
TZD effects on fat
A
Inc AMPK & insulin sensitivity @ target tissues
4
Q
TZD effects on fat - cytokines
A
INC:
“good” adipocytokines
inflam cytokines
DEC:
“bad” cytokines
5
Q
TZD effects on SKM
A
Inc GLUT4 translocation –> inc glucose uptake
6
Q
TZD effects on Liver
A
Dec hep glucose produx
7
Q
TZD - which may have PPAR alpha agonist activity?
A
Pioglitazone
8
Q
TZD AE
A
Hepatotox Edema Weight gain Osteoporosis Bladder cancer risk (pioglitazone)
9
Q
TZD considerations - onset
A
Relatively slow effects (1-2 weeks onset; 2-3 months
max effect: due to genomic effects?)
10
Q
Baseline & monitor ____
A
AST
ALT
Edema
11
Q
Monitor for signs of ____
A
HF
12
Q
TZD CI
A
Symptomatic HF Bladder cancer (hist or act) Bone fracture (hist or risk) Liver dz (active)
