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ERM > Ketone bodies & ketosis part 3 > Flashcards

Ketone bodies & ketosis part 3 Flashcards

1
Q

AKA presentation

A 
often see hypo-g
metabolic acidemia
EtOH w/drawal
N/V
Hypovolemia
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2
Q

EtOH metab

A

Only in liver

Yield cytosolic NADH, mitochondrial NADH & acetyl CoA

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3
Q

Hypo-G in AKA

A
  • No food intake

- EtOH metab –> inc cytosolic NADH –> Dec gluconeogenesis

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4
Q

Cytosolic NADH effect in AKA

A

Dec substrates for gluconeogenesis

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5
Q

EPI in AKA

A

inc

Stim HSL to release FA from TG

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6
Q

G:I in AKA

A

inc

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7
Q

Acetyl CoA in AKA

A

inc by a lot

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8
Q

Ketogenesis in AKA

A

super high

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9
Q

Glycogenolysis - key enzymes

A

Phosphorylase

Debranching enzyme

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10
Q

Gluconeogenesis - key enzymes

A

G6Pase
FBPase-1
PEPCK

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11
Q

Lipolysis - key enzymes

A

Hormone sensitive lipase (HSL)

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12
Q

B-oxidation key enzymes

A

CPT-1

B-Ox enzymes

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13
Q

Ketogenesis key enzymes

A

HMG CoA lyase

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14
Q

Ketolysis key enzymes

A

Succinyl CoA transferase

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15
Q

Notable changes for fasting 12 hr - INC:

A

g:i
glycogenolysis ***
gluconeogenesis

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16
Q

Notable changes for fasting 12 hr - DEC:

A

plasma glucose

glucose uptake

17
Q

Notable changes for fasting 3 day - INC:

A 
g:i **
gluconeogenesis *****
plasma kb
ketogenesis
muscle ketolysis
18
Q

Notable changes for fasting 3 day - DEC:

A

plasma glucose

glucose uptake

19
Q

Notable changes for 1 week fast - INC:

A 
g:i
gluconeogenesis (but slowed down)
plasma kb
ketogenesis ****
ketolysis (brain > muscle)
20
Q

Notable changes for 1 week fast - DEC

A

plasma glucose but not hypo-g

glucose uptake

21
Q

Notable changes for DKA in uncontrolled T1DM - INC:

A 
g:i
plasma glucose
glycogenolysis (1st 24 hrs)
plasma kb
ketogenesis***
ketolysis
22
Q

Notable changes for DKA in uncontrolled T1DM - DEC

A

glucose uptake

pH drops below 7.35 (life threatening)

23
Q

Notable changes in AKA - INC

A 
g:i
gluconeogenesis
plasma kb ***
ketogenesis *****
ketolysis
24
Q

Notable changes in AKA - DEC

A 
plasma glucose (hypo-g)
glucose uptake

pH < 7.35 but not as bad as DKA

ERM (27 decks)

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