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ERM > Ketone bodies & ketosis part 2 > Flashcards

Ketone bodies & ketosis part 2 Flashcards

1
Q

12 hr fast - RBC & brain fuel use

A

Glucose only

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2
Q

12 hr fast - Liver fuel use

A

Inc FA use as glucagon:insulin inc –> dec glycolysis

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3
Q

12 hr fast - adipose and muscle fuel use

A

Inc FA use as glucagon:insulin inc –> Dec GLUT4 transport

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4
Q

3 day fast - RBC fuel use

A

glucose

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5
Q

3 day fast - brain fuel use

A

Glucoe & inc KB (starting day 3) as transporters inc

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6
Q

3 day fast - muscle fuel use

A

FA & inc KB (starting day 1) as Pkb inc

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7
Q

3 day fast - liver and adipose fuel use

A

FA

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8
Q

Glucagon:insulin ratio after 3 day fast

A

Plateaus out at ~10x initial value

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9
Q

Body process of longer fasts

A

Brain using more KB than muscle
Dec total body glucose–>gluconeogenesis & proteolysis now less than day 3 –> Pglucose plateaus at low end of normal but NOT hypo-g

Pkb plateaus, Ketonemia ~10x normal
Plasma HCO3 falls but pH usually > 7.35
Not acidemia

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10
Q

RBC fuel in week long fast

A

Glucose

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11
Q

Brain fuel in week long fast

A

KB>glucose

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12
Q

Muscle fuel in week long fast

A

FA & KB

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13
Q

Liver & adipose fuel in week long fast

A

FA

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14
Q

Glucagon:insulin ratio during fasting in untreated T1DM

A

Super duper high because insulin is 0

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15
Q

Processes inhibited in uncontrolled T1DM

A

GLUT-4-mediated glucose uptake into muscle and fat

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16
Q

Processes stimulated in uncontrolled T1DM

A

Muscle proteolysis + adipose lipolysis –> gluconeogenesis

Gluconeogenesis + glycogenolysis –> Hep glucose output –> Hyperglycemia

17
Q

Fasting + untreated T1DM

A

Ketoacidosis is life threatening w/in 1 day because Pkb shoots up

18
Q

Very high Glucagon:insulin in uncontrolled T1DM

A

Adipose lipolysis –>severe ketonemia
Hyper-g –> dehydration and loss of plasma HCO3
Combined lead to DKA –> metabolic acidemia

ERM (27 decks)

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