SU/Non SU

Question 1

Sulfonylurea examples

Answer 1

Glimerpiride
Glipizide
Glyburide

Question 2

Non-sulfonylurea examples

Answer 2

Nateglinide

Repaglinide

Question 3

(Non) - Sulfonylurea MOA

Answer 3

Bind to extracellular “sulfonylurea-R subunit” of K+-ATP channels of beta cell –> K+-ATP channel closure –> depolarization –> inc activation of volt gated Ca channels –> inc insulin secretion

Still increases insulin secretion even if plasma glucose becomes too low

Question 4

SU & Non-SU AE

Answer 4

Hypoglycemia
Weight gain

Skin rash/sun sensitivity (SU)

Question 5

SU & Non-SU consideration

Answer 5

Will not work in T1DM due to no beta cells

Question 6

Which SU are converted to inactive metab by liver?

Answer 6

Glipizide

Glimepiride

Question 7

Glyburide excretion

Answer 7

50% renal active metab or unchanged drugs

50% feces

Question 8

Which SU have intermediate dosing (10-24) hrs

Answer 8

Glipizide

Question 9

Which SU have long dosing?

Answer 9

Glyburide (QD–> BID beyond 10 mg)

Glimepride