Type 1 Diabetes and Hypo management Flashcards
what are the symptoms of T1DM
weight loss, excessive thirst, polyuria, fatigue
can also be headache, anxiety, muscle spasm
what are GAD autoantibodies
antibody often seen in T1DM, destroys GAD cells (in pancrease) which produce the enzyme glutamate decarboxylase
what is T1DM
autoimmune beta cell destruction leading to absolute insulin deficiency
what is type two DM
progressive sensory defect on the background on insulin resistance
what is gestational DM
diabetes diagnosed in 2nd/3rd trimester that is not clearly overt diabetes
what are the two types of monogenic diabetes
neonatal DM and MODY
give an example of an endocrine pancreas disease that can cause diabetes
cystic fibrosis
what can induce diabetes
drugs (HIV treatment, organ transplant) or chemical
what cell mediates T1DM
T cells
what is the onset of T1DM like
prolonged, months to years
what causes T1DM
genetic susceptibility and environmental factors
how long before symptoms begin
need to have lost 80-90% of beta cells before marked hyperglycaemia occurs
what other autoimmune conditions is T1DM associated with
thyroid, coeliac (1:20 will have T1DM), addisons, pernicious anaemia, vitiligo
what is LADA
latent autoimmune diabetes of adulthood
what is the presentation of LADA
slowly progressive disease onset, non obese, no FHx T2DM, age >35 at onset, mild insulin resistance, low C peptide, HLA gene positive (GAD)
what does a positive GAD mean
80% of + will be insulin dependent in 6 years
75-84% of recent onset T1DM will be GAD +
what does C peptide show
how much insulin is being produced, low= low
what is the incidence of T1DM in scotland
1 in 25, 3rd in the world
what is polyglandular endocrinopathy type 2
autoimmune conditions that causes T1DM along with (any/all of):
- addisons disease
- hypothyroidism
- hypogonadism
- vitiligo
- coeliac
(not linked to a gene)
what is polyglandular endocrinopathy type 1
(autosomal recessive) mild immune deficiency with T1DM, addisons, hypothyroidism, hypogonadism, vitiligo, coeliac PLUS there may also be: -alopecia -pernicious anaemia -hypoparathyroidism
what is the difference in histology between T1DM and T2DM
T1DM- lymphocytic infiltrate attacking islets
T2DM- amyloid deposition in islet
what are the islet autoantibodies
IA-2, IA-2beta, GAD65, ZnT8
how many newly diagnosed cases will have positive antibodies - what can cause them to vary
70-80%
age, ethnicity, gender, quality of assay
what autoantibodies are most commonly tested
IA-2, GAD, Znt8
what gene is associated with T1DM
chromosome 6, HLA DR3, DR4 and DQ
how does insulin deficiency affect protein metabolism
increase protein catabolism =
increased AA in plasma
urinary nitrogen loss
how does insulin deficiency affect lipid metabolism
increased lipolysis =
increased plasma FFA
ketogenesis
ketonuria
what is the function of insulin
released in response to carbohydrate, suppresses glycolysis and stimulate glycogenesis and lipogenesis
is insulin anabolic or catabolic
anabolic- insulin deficiency a catabolic state
what are the features of insulin deficiency
accelerated starvation, hyperglycaemia, hepatic gluconeogenesis, lipolysis, protein catabolism, reduced glucose storage
what happens to the alpha and delta cells when beta cells destroyed
are dysregulated
what are the symptoms of diabetic ketoacidosis
vomiting, abdominal pain, altered consciousness,
acidotic beathing, pH
<7.3, urine ketones +++, dehydrated, coma/death
what is the classical presentation of T1DM
acute onset, presents with DKA or severe symptoms, pre-school and peri-puberty (can present at any age), non obese, insulin dependant, FHx uncommon
what are the BM diagnosis guidelines
a random venous plasma glucose concentration ≥ 11.1 mmol/l or
a fasting plasma glucose concentration ≥ 7.0 mmol/l (whole blood ≥ 6.1 mmol/l) or
two hour plasma glucose concentration ≥ 11.1 mmol/l two hours after 75g anhydrous glucose in an oral glucose tolerance test (OGTT).
An HbA1c of 48mmol/mol (6.5%) is recommended as the cut off point for diagnosing diabetes
what are the long acting, background insulins
glargine and determir
what are the mealtime insulins
aspart, lispro and gulisine
why do you need more insulin to achieve homeostasis in T2DM
as patients will all be hyper insulinaemic (too much insulin compared to glucose)