Steroid Workshop Flashcards
what do glucocorticoids work through
form a dimer with glucocorticoid receptor
what is the action of bound and unbound glucocorticoid
dimer- (GC+GR) activates transcription
monomer (GC)- represses transcription
what can happen if glucocorticoid binds to mineralocorticoid receptor
skin atrophy and delayed wound healing
what type of molecules are steroids
fatty acids- not soluble in blood so bind to plasma proteins
what DNA sequences respond to steroids
glucocorticoid response elements
+GRE sequence favors GR dimer formation
- target gene expression induced
nGRE sequence suppresses GR dimer formation- gene expression repressed
how else can steroids affect transcription
can tether other transcription factors- causing a lot of genes to be blocked
what is a heterodimer
two bound different proteins: mineralocorticoid + glucocorticoid
how can glucocorticoids stop the action of mineralocorticoids
bind to the mineralocorticoid receptor
how can the block of mineralocorticoids by glucocorticoid be prevented
co administration of mineralocorticoids - can prevent the glucocorticoid induced skin atrophy and impaired wound healing
how are glucocorticoid involved in alcohol
GR activated in reward centre in brain (Amygdala) - blocking this with glucocorticoid reduced alcohol craving in glucocorticoid
