Tumour pathology 4

Question 1

Cell size inadequacy:

Answer 1

G1 or G2 arrest

Question 2

Nutrient supply inadequacy:

Answer 2

G1 arrest

Question 3

Essential external stimuli lacking:

Answer 3

G1 arrest

Question 4

DNA is not replicated

Answer 4

S arrest

Question 5

DNA damage is detected:

Answer 5

G1 or G2 arrest

Question 6

Chromosome mis-alignment:

Answer 6

M-phase arrest

Question 7

INK4A

Answer 7

p16

Question 8

INK4B

Answer 8

p15

Question 9

INK4C

Answer 9

p18

Question 10

INK4D

Answer 10

p19

Question 11

CIP1

Answer 11

p21

Question 12

Virtually all cancers are dysregulated at G1-S because of mutation in one of which four genes?

Answer 12

• Rb
• p16
• CDK4
• Cyclin D

Question 13

KIP1

Answer 13

p27

Question 14

KIP2

Answer 14

p57

Question 15

3 functions of p53:

Answer 15

• Initiates apoptosis
• Cell cycle arrest
• Repairs DNA damage

Question 16

The primary defect in cancer is:

Answer 16

Uncontrolled cell proliferation via cell cycle dysregulaiton