Drug Distribution

Question 1

State the factors that determine drug distribution (6)

Answer 1

• Membrane characteristics
• Disease/Other Drugs
• Plasma protein binding
• Elimination
• Transport mechanisms
• Perfusion of tissue

Question 2

Describe plasma protein binding

Answer 2

• Many drugs bind to proteins such as ALBUMIN, but only unbound drugs are active.
• Binding is reversible
  and can be affected by renal failure, hypoalubinaemia, pregnancy, other drugs and saturability of binding