Chronic Inflammation Flashcards
State some features of chronic inflammation.
Tissue/organ damage
Necrosis
Loss of function
Healing is a characteristic with the presence of granulation tissue, scarring and fibrosis.
Presence of blood cells - Lymphocytes, macrophages and plasma cells
State what is meant by ‘fibrosis’?
Thickening and scarring of connective tissue, usually as a result of injury
State the cells that have immunological memory?
B lymphocytes and T lymphocytes
State the roles of T lymphocytes in chronic inflammation.
- Produce cytokines (Attract, hold and activate macrophages. Increase permeability of the target cell membrane)
- Produce interferons (Attract and stimulate other relevant cells, have antiviral effects)
- Damage and lyse other cells and destroy the antigen. This is done via the chemical mechanism utilising granule proteins
State the role of B lymphocytes in chronic inflammation.
- Differentiate into plasma cells which produce antibodies
- Facilitate immune response and immune memory
- Act with macrophages, as they have antigen presenting capacity
State the roles of macrophages in chronic inflammation
- Remove debris
- Antigen presenting cells
- Phagocytosis
Fibroblasts are
Metabolically active, motile cells and they make and assemble structural proteins such as collagen.
Epithelioid histoioytes are
Activated macrophages
State the features of giant cells
- Formed from the fusion of macrophages to form larger cells
- Large cytoplasm and multinucleate
- Found both inside and outside granuloma
State the types of giant cells.
- Silicone associated
- Langhans associated
- Foreign body type
- Warthin-Finkeldy type
