Tumors of Bone and Soft Tissue Flashcards
Chemotherapy for osteosarcoma
Adriamycin (doxurubicin)
Adriamycin side effect
cardiac toxicity
Mesenchymal tissue makes up
Bone, Muscle, Cartilage, Fat
Blood vessel lining is from
endothelial
Steps to cancer: (put in order)
Resist death Invade Proliferate Angiogenesis Growth
Proliferate Growth Resist Death Angiogenesis Invasion
Nerve sheath is made of
neuroectodermal
Somatic model of cancer
Varied population of mutant cells
Tumors evolve by natural selection
Cells with growth advantage propagate/mutate
Individual populations may have chemo resistance
Oncogenes are
Accelerators, gain of function, Gas pedel
Example of hereditary cancer syndromes
p53 deficiency (Li-Fraumeni) FAP
Which theory of cancer has a varied population of cells with varied resistance?
Somatic model
Stem cell model of cancer
Arise from defined progenitor cell
Single cell of origin, small population in tumor
Differentiated cells resistant to conventional treatment
Loss of the ‘brake’ in cancer
Loss of a tumor suppressor gene
Theory of cancer that arises from a single cell
Stem cell model
DNA methylation or epigenetic changes may lead to
Changes in gene expression
Best scan for soft tissue tumor
MRI
