Genetics of Psychiatry

Question 1

The heritability of brain composition is around

Answer 1

85%

Question 2

Enviromental influences have a _______ effect on psychiatric disorders

Answer 2

Diffuse - not tied pecifically

Question 3

Low heritability indicates

Answer 3

Greater extent of environmental influence

Question 4

What type of genetic variation currently has clinical value?

Answer 4

Rare and recurrent genetic variation (genomic CNVs)

Question 5

Proportion of phenotypic variation of a trait in a population that is due to genetic differences

Answer 5

Heritability
(difference from the mean)

–> if no variance in the population, there is no heritability

Question 6

Mutation associated with schiz, autism, ADHD

Answer 6

16p11.2

Question 7

Pleiotropic means that

Answer 7

same risk variant may underlie multiple disorders

Question 8

How do you estimate heritability?

Answer 8

compare genetic similarity within a patient group to similarity within a control group

Question 9

Most heritability is due to

Answer 9

Common variants

Question 10

Heritability of major disoders like ______, _____, and _____ is about 50%

Answer 10

schizophrenia, bipolar disorder, autism