Tumor Translocations Flashcards
1
Q
t(9,22)
A
CML
Bcr-Abl
Constitutive activation of Tyrosine Kinase
2
Q
t(8;14)
A
Burkitt Lymphoma
c-myc activation-
Transcription activator controlling cell proliferation, differentation and apoptosis
3
Q
t(11;14)
A
Mantle Cell Lymphoma
Cyclin D1 activation- progression of G1 to S phase
4
Q
t(14;18)
A
Follicular Lymphoma or DIffuse B cell
Bcl-2 activation-anti-apoptotic (follicular)
Bcl-6 disactivation (Diffuse)
5
Q
t(15;17)
A
M3 subtype of AML
Abnormal retinoic acid receptor that is responsive to Vitamin A
6
Q
t(8;21)
A
AML
Still with Auer Rods
7
Q
t(12,21)
A
Good prognosis T-ALL/B-ALL
8
Q
T(9,22)
A
T-ALL/B-ALL
9
Q
(11;18) (14, 18) or (1:14)
A
Marginal Zone Lymphoma
Upregulation of BCL10 Nf-KB
10
Q
inv16
A
AML
11
Q
deletions of 5q and 7q
A
AML associated with chemotherapy
12
Q
deletion 13q
A
CLL
13
Q
t(11,22)
A
Ewing Sarcoma
