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Step 1 Fast Facts > Tumor/cell Markers > Flashcards

Tumor/cell Markers Flashcards

1
Q

GFAP

A

(from astrocytes)
Glioblastoma Multiforme
Pilocytic atrocytoma

Ependymoma?

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2
Q

S-100

A

Neural crest cell origin

Melanoma
Schwannoma

Langerhans cell histiocytosis

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3
Q

CA-125

A

Monitors progression of ovarian cancer

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4
Q

LDH

A

Dysgerminoma

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5
Q

AFP

A

Yolk Sac tumor (endodermal sinus)

Mature testicular teratoma

Embryonal testicular carcinoma when mixed

Hepatocellular Carcinoma

Ataxia tenancictasia

Hepatoblastoma

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6
Q

B-hCG

A

Choriocarcinoma
Mature testicular teratoma
Embryonal testicular carcinoma when mixed

Hydatiform moles

Shares a subunit with TSH, LH and FSH

Can bind to TSH receptor and cause hyperthyroidism

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7
Q

Desmin and myoglein

A

Rhabdomyosarcoma (sarcoma botryoides) of vagina

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8
Q

CD7

A

T cell marker

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9
Q

CD14

A

Monocyte-macrophage lineage

Endotoxins bind to

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10
Q

CD31

A

Liver angiosarcoma

PECAM

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11
Q

CEA

A

Colon rectal cancer measures recurrence

Pancreatic

gastric, breast and medullary thyroid cancers

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12
Q

Alkaline phosphatase

A

Obstructivve hepatobiliary disease

HCC

Bone disease

Paget disease of bone

Seminoma (placental ALP)

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13
Q

ALT >AST

A

Viral hepatitis

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14
Q

AST>ALT

A

Alcoholic hepatitis

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15
Q

Amylase

A

Acute pancreatitis, mumps

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16
Q

Ceruloplasmin

A

Decreaesed in Wilson disease

17
Q

Gamma-glutamyl transpeptidase

A

Increaed in liver and biliary disease but not bone disease (more specific)

Associated with alcohol usse

18
Q

Lipase

A

Acute pancreatitis (most specific)

19
Q

HLA-A3

A

Hemochromatosis

20
Q

HLA-B27

A

Psoriatic Arthritis
ankylosing Spondylitis
arthritis of inflammatory bowel disease
reactive arthritis

21
Q

HLA-DQ2/DQ8

A

Celiac disease

22
Q

HLA-DR2

A

Musltiple sclerosis, hay fever, SLE, Goodpasutre

23
Q

HLA-DR3

A

DM1, SLE, Graves

24
Q

HLA DR4

A

Rheumatoid arthritis, DM1

25
Q

HLA-DR5

A

Pernicious anemia, Hashimotos

26
Q

CA-19-9

A

Pancreatic adenocarcinoma

27
Q

CD16

A

NK cells (binds Fc of IgG)

28
Q

CD56

A

NK cells

29
Q

contains CD3, CD4 and CD25

A

Regulatory T cells (CD25 is a chain of IL-2 recpetor)

30
Q

CD40

A

Macrophages B cells

31
Q

Transcription factor FOXP3

A

Regulatory T cells

32
Q

CA-15-3/CA-27-29

A

Breast Cancer

32
Q

Calcitonin

A

Medullar thyroid carcinoma

Step 1 Fast Facts (12 decks)

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