Tumor/cell Markers

Question 1

GFAP

Answer 1

(from astrocytes)
Glioblastoma Multiforme
Pilocytic atrocytoma

Ependymoma?

Question 2

S-100

Answer 2

Neural crest cell origin

Melanoma
Schwannoma

Langerhans cell histiocytosis

Question 3

CA-125

Answer 3

Monitors progression of ovarian cancer

Question 4

LDH

Answer 4

Dysgerminoma

Question 5

AFP

Answer 5

Yolk Sac tumor (endodermal sinus)

Mature testicular teratoma

Embryonal testicular carcinoma when mixed

Hepatocellular Carcinoma

Ataxia tenancictasia

Hepatoblastoma

Question 6

B-hCG

Answer 6

Choriocarcinoma
Mature testicular teratoma
Embryonal testicular carcinoma when mixed

Hydatiform moles

Shares a subunit with TSH, LH and FSH

Can bind to TSH receptor and cause hyperthyroidism

Question 7

Desmin and myoglein

Answer 7

Rhabdomyosarcoma (sarcoma botryoides) of vagina

Question 8

CD7

Answer 8

T cell marker

Question 9

CD14

Answer 9

Monocyte-macrophage lineage

Endotoxins bind to

Question 10

CD31

Answer 10

Liver angiosarcoma

PECAM

Question 11

CEA

Answer 11

Colon rectal cancer measures recurrence

Pancreatic

gastric, breast and medullary thyroid cancers

Question 12

Alkaline phosphatase

Answer 12

Obstructivve hepatobiliary disease

HCC

Bone disease

Paget disease of bone

Seminoma (placental ALP)

Question 13

ALT >AST

Answer 13

Viral hepatitis

Question 14

AST>ALT

Answer 14

Alcoholic hepatitis

Question 15

Amylase

Answer 15

Acute pancreatitis, mumps

Question 16

Ceruloplasmin

Answer 16

Decreaesed in Wilson disease

Question 17

Gamma-glutamyl transpeptidase

Answer 17

Increaed in liver and biliary disease but not bone disease (more specific)

Associated with alcohol usse

Question 18

Lipase

Answer 18

Acute pancreatitis (most specific)

Question 19

HLA-A3

Answer 19

Hemochromatosis

Question 20

HLA-B27

Answer 20

Psoriatic Arthritis
ankylosing Spondylitis
arthritis of inflammatory bowel disease
reactive arthritis

Question 21

HLA-DQ2/DQ8

Answer 21

Celiac disease

Question 22

HLA-DR2

Answer 22

Musltiple sclerosis, hay fever, SLE, Goodpasutre

Question 23

HLA-DR3

Answer 23

DM1, SLE, Graves

Question 24

HLA DR4

Answer 24

Rheumatoid arthritis, DM1

Question 25

HLA-DR5

Answer 25

Pernicious anemia, Hashimotos

Question 26

CA-19-9

Answer 26

Pancreatic adenocarcinoma

Question 27

CD16

Answer 27

NK cells (binds Fc of IgG)

Question 28

CD56

Answer 28

NK cells

Question 29

contains CD3, CD4 and CD25

Answer 29

Regulatory T cells (CD25 is a chain of IL-2 recpetor)

Question 30

CD40

Answer 30

Macrophages B cells

Question 31

Transcription factor FOXP3

Answer 31

Regulatory T cells

Question 32

CA-15-3/CA-27-29

Answer 32

Breast Cancer

Question 32

Calcitonin

Answer 32

Medullar thyroid carcinoma